Boosting immune response against metastatic colon cancer
Metabolic reprogramming to boost the fitness of anti-tumor immunity against metastatic colon cancer
['FUNDING_R37'] · COLD SPRING HARBOR LABORATORY · NIH-11142217
This study is looking at ways to make cancer treatments work better for people with metastatic colorectal cancer by boosting the energy and effectiveness of certain immune cells, so they can fight the cancer more effectively.
Quick facts
| Phase | ['FUNDING_R37'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLD SPRING HARBOR LABORATORY (nih funded) |
| Locations | 1 site (COLD SPRING HARBOR, UNITED STATES) |
| Trial ID | NIH-11142217 on ClinicalTrials.gov |
What this research studies
This research aims to improve immunotherapy for metastatic colorectal cancer by enhancing the metabolic fitness of immune cells, specifically CD8+ T cells. The approach focuses on activating a specific metabolic pathway that could increase the effectiveness of existing cancer treatments. By understanding how cancer cells and immune cells compete for resources, the researchers hope to find ways to make the immune response stronger against tumors. This innovative strategy addresses the challenges faced by patients with a subtype of colorectal cancer that typically does not respond well to current therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with metastatic colorectal cancer, particularly those with the microsatellite stable subtype.
Not a fit: Patients with early-stage colorectal cancer or those with other cancer types may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with metastatic colorectal cancer, potentially improving survival rates.
How similar studies have performed: Other research has shown promise in enhancing immune responses through metabolic reprogramming, suggesting that this approach could be effective.
Where this research is happening
COLD SPRING HARBOR, UNITED STATES
- COLD SPRING HARBOR LABORATORY — COLD SPRING HARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BEYAZ, SEMIR — COLD SPRING HARBOR LABORATORY
- Study coordinator: BEYAZ, SEMIR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: anti-cancer therapy