Condition

Aortic Stenosis clinical trials and research

• 55Clinical trials
• 22NIH research projects
• 1New in 30 days
• 31Countries

Newest Aortic Stenosis clinical trials

All recruiting trials (55)

• Exercise and nutrition support before and after TAVI for older adults with aortic stenosis

  This trial tests whether a personalized exercise program plus protein and iron supplements before and after a transcatheter valve replacement can help older adults with aortic stenosis recover better than standard care.

  Recruiting University Hospital of Ferrara · Ferrara, FE · NCT07895719

• Association Between Aortic Valve Area Changes and Pulmonary Congestion After TAVI

  This study tests whether improvements in aortic valve opening after TAVI relate to reductions in lung congestion measured by ultrasound in adults with severe aortic stenosis.

  Recruiting Istanbul University - Cerrahpasa · Istanbul, Istanbul · NCT07794436

• Systematic 14-day ambulatory heart monitoring after TAVI

  After TAVI, patients with certain heart conduction abnormalities will try 14 days of wearable ECG monitoring to see if it lowers the chances of sudden death, symptomatic heart rhythm problems, or stroke within a year compared to standard follow-up.

  Recruiting Institut universitaire de cardiologie et de pneumologie de Québec, University Laval · Québec, Quebec · NCT07739316

• Echo-AVCS: Drawing AI-powered clues from heart scans to confirm severe aortic stenosis

  This study tests an AI-based echocardiography score to help confirm severe aortic stenosis in adults who are also getting CT calcium scoring.

  Recruiting at 4 sites Azienda Ospedaliera "Sant'Andrea" · Bologna and 4 other locations · NCT07620925

• TAVI without on-site heart surgery: can selected centers do it safely?

  This trial tests whether transcatheter aortic valve implantation can be done safely in certain hospitals that don’t have on-site cardiac surgery, for patients with severe aortic stenosis who are appropriately selected.

  Recruiting at 10 sites University Hospital of Ferrara · Andria and 10 other locations · NCT07604402

• Willem AI for early detection of aortic stenosis from a 12‑lead ECG

  This project will test whether the Willem AI can detect aortic stenosis from routine 12‑lead ECGs in adults.

  Recruiting at 2 sites Idoven 1903 S.L. · Bonn and 1 other locations · NCT07479992

• Monitoring progression of chronic cardiovascular conditions

  This project will collect wearable physiologic data from adults with cardiovascular conditions to see how their heart disease changes over time.

  Recruiting Prolaio · Chicago, Illinois · NCT07420907

• Siegel transcatheter aortic valve replacement for symptomatic severe aortic stenosis

  This trial will test the Siegel TAVR heart valve to see if it is safe and helps adults with symptomatic severe native aortic stenosis who are eligible for transfemoral TAVR.

  Recruiting MiRus · Atlanta, Georgia · NCT07278310

• EmStop Embolic Protection System for TAVR in Aortic Valve Stenosis

  This study tests whether the EmStop protective device can safely capture and remove debris during transcatheter aortic valve replacement in adults with severe aortic valve stenosis.

  Recruiting at 7 sites EmStop Inc · Thousand Oaks, California and 6 other locations · NCT07276711

• Impedance cardiography (HYPERGRAPH) test to detect heart decompensation and replacement fibrosis in aortic stenosis

  This project will test whether a quick impedance cardiography (HYPERGRAPH) test can detect left ventricular decompensation linked to replacement fibrosis in people with aortic stenosis.

  Recruiting Dermed Diagnostics, Inc. · Chicago, Illinois · NCT07230964

• Shockwave IVL of the common femoral artery before large-bore TAVR access and closure

  This will test whether using Shockwave intravascular lithotripsy on heavily calcified common femoral arteries before TAVR lowers access-site complications for adults with severe aortic stenosis.

  Recruiting University of Tennessee Graduate School of Medicine · Knoxville, Tennessee · NCT07205068

• Using blood markers to predict conduction problems after TAVI

  This study will test whether blood levels of inflammation and fibrosis markers taken before TAVI can help predict which patients with severe aortic stenosis will develop new conduction problems or need a permanent pacemaker.

  Recruiting Clinical Hospital Center Rijeka · Rijeka, Croatia · NCT07201363

• DELINEATE-Prospective: AI-assisted echocardiogram analysis for valve disease

  This project will test whether an AI system can automatically analyze echocardiograms to help doctors detect valve problems in adults who get heart ultrasounds.

  Recruiting Columbia University · New York, New York · NCT07197736

• AI analysis of echocardiograms to identify severe low-gradient aortic stenosis

  This project will test an AI tool on clinical echocardiogram images to see if it can reliably identify adults with severe low-gradient aortic stenosis.

  Recruiting National Institute of Cardiology, Warsaw, Poland · Warsaw, Masovian Voivodeship · NCT07144189

• Surgical implantation of a polymer prosthetic mitral or aortic valve

  This will test a surgically implanted polymer heart valve to see if it is safe and works well for adults who need mitral or aortic valve replacement.

  Recruiting Mitrassist Lifesciences Limited Co., Ltd. · Shanghai, Shanghai Municipality · NCT07097740

• How TAVI affects gut bacteria in people with severe aortic stenosis

  This will test whether transcatheter aortic valve implantation (TAVI) changes the gut microbiota and related blood markers in people with severe aortic stenosis.

  Recruiting Hippocration General Hospital · Athens · NCT07052071

• Transaxillary TAVR guided only by echocardiography

  This tests whether doing transaxillary TAVR using only echocardiography is safe and practical for people with severe aortic stenosis who are suitable for axillary access.

  Recruiting Chinese Academy of Medical Sciences, Fuwai Hospital · Beijing, Beijing Municipality · NCT07035847

• Preventing low oxygen during sedated TAVI using SuperNO2VA versus standard oxygen

  This will test whether the SuperNO2VA nasal mask prevents low oxygen and poor breathing better than standard oxygen for people 65 and older having TAVI under sedation.

  Recruiting Ankara Bilkent Sehir Hastanesi · Ankara · NCT07006064

• Evaluating a new sizing algorithm for transcatheter aortic valve replacement in patients with bicuspid aortic stenosis

  This study is testing a new sizing method for heart valve replacement to see if it helps people with a specific heart condition feel better after their procedure.

  Recruiting at 17 sites World Health Research Inc. · St Leonards, New South Wales and 19 other locations · NCT06991517

• Long-term outcomes with the SAPIEN 3 Ultra RESILIA heart valve in adults

  This study tests how the SAPIEN 3 Ultra RESILIA valve performs over 10 years in adults undergoing transfemoral TAVR for severe aortic valve disease.

  Recruiting Institut für Pharmakologie und Präventive Medizin · Bad Oeynhausen, North Rhine-Westphalia · NCT06953206

• Surgical aortic valve replacement versus TAVR for low-risk severe aortic stenosis

  This study tests whether surgical aortic valve replacement or transcatheter aortic valve replacement (TAVR) gives better safety and outcomes for people with severe, calcific aortic stenosis who are at low surgical risk.

  Recruiting at 37 sites Osaka University · Matsudo, Chiba and 36 other locations · NCT06924151

• Identifying sex-specific biological markers in valvular heart disease

  This study is testing if special heart scans can help find different biological markers for men and women with aortic valve disease to improve treatment and recovery after surgery.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06780241

• Redo Transcatheter Aortic Valve Replacement for valve failure

  This study is testing if a second Transcatheter Aortic Valve Replacement can safely help patients who had problems with their first valve replacement.

  Recruiting at 70 sites Medtronic Cardiovascular · Birmingham, Alabama and 70 other locations · NCT06777368

• Integrated prenatal and postnatal treatment for newborns with critical congenital heart disease

  This study is testing a new approach that combines care before and after birth for newborns with serious heart defects to see if it can improve their treatment and recovery.

  Recruiting Beijing Anzhen Hospital · Beijing · NCT06768008

• Comparing self-expandable and balloon-expandable valves for aortic dilation treatment

  This study is testing whether self-expandable or balloon-expandable valves work better for people with aortic dilation who are getting a heart valve replacement.

  Recruiting China National Center for Cardiovascular Diseases · Beijing, Beijing Municipality and 2 other locations · NCT06743568

• Effects of aortic valve calcification on outcomes after valve replacement

  This study is testing how the amount of calcium buildup around the aortic valve affects the long-term health of people who have had a valve replacement for severe aortic stenosis.

  Recruiting Eunpyeong St. Mary's Hospital · Seoul · NCT06722066

• Identifying biomarkers for cardiovascular events in aortic stenosis patients

  This study is trying to find biological markers that can help identify aortic stenosis patients at risk for heart problems, especially those getting a new heart valve, so they can get treatment sooner.

  Recruiting at 2 sites Hospices Civils de Lyon · Lyon and 1 other locations · NCT06713889

• Early transcatheter aortic valve replacement for critical aortic stenosis with cardiogenic shock

  This study will test whether doing a transcatheter aortic valve implantation within 12 hours helps people with critical aortic stenosis and cardiogenic shock survive and recover better than stabilizing them first and treating later.

  Recruiting Copenhagen University Hospital, Rigshospitalet · Copenhagen O · NCT06638268

• Using AI to Diagnose Heart Conditions in Outpatients

  This study is testing if new AI tools can help doctors diagnose heart problems like aortic stenosis and diastolic dysfunction in older patients during their regular check-ups.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT06580158

• Evaluating heart conduction issues after aortic valve replacement

  This study is testing how often new heart conduction problems happen after aortic valve replacement and whether they can be fixed, focusing on patients who develop specific issues after the procedure.

  Recruiting Institut d'Investigació Biomèdica de Bellvitge · L'Hospitalet de Llobregat, Barcelona · NCT06481137

• Evaluating the effects of stopping beta-blockers during heart valve replacement

  This study is testing if stopping beta-blockers before heart valve replacement can help prevent complications for adults with severe aortic stenosis.

  Recruiting at 11 sites University Hospital, Basel, Switzerland · Graz and 10 other locations · NCT06472934

• Understanding Aortic Stenosis Progression and Treatment Outcomes

  This study looks at how aortic stenosis changes over time and how well treatments work, especially after valve replacement, by regularly checking patients' hearts and gathering health information for four years.

  Recruiting University of Edinburgh · Edinburgh · NCT06047561

• Evaluation of the Navitor Valve for Aortic Stenosis

  This study tests how well the Navitor heart valve works and how safe it is for people with aortic stenosis in everyday situations.

  Recruiting at 44 sites Abbott Medical Devices · Adelaide and 49 other locations · NCT06008080

• Comparing aspirin use versus no antithrombotic therapy after heart valve replacement

  This study tests whether taking aspirin after heart valve replacement helps patients feel better compared to not taking any blood-thinning medicine.

  Recruiting Phase 4 OCEAN-SHD Study Group · Shinjuku, Tokyo · NCT06007222

• Transfemoral aortic valve replacement for high-risk patients without on-site surgery

  This study is testing if a new heart valve procedure can safely help high-risk patients with severe aortic stenosis who are treated in hospitals without heart surgery available.

  Recruiting at 4 sites AUSL Romagna Rimini · Acquaviva delle Fonti, Bari and 3 other locations · NCT05886517

• Understanding how aortic stenosis progresses and who is at risk

  This study tests whether imaging, genetic, and immune markers can predict which people with moderate aortic valve narrowing will quickly develop severe disease.

  Recruiting at 3 sites Heinrich-Heine University, Duesseldorf · Bonn and 2 other locations · NCT05851209

• Assessing changes in aortic diameter after valve replacement

  This study looks at how the size of the aorta changes after patients have a heart valve replacement to see if it gets bigger or stays the same, especially for those who already had a larger aorta.

  Recruiting China National Center for Cardiovascular Diseases · Beijing, Beijing Municipality · NCT05739253

• Lowering Lipoprotein(a) to Slow Aortic Valve Stenosis Progression

  This study is testing if a monthly injection of a new drug can help slow down the worsening of aortic valve narrowing in adults aged 50 to 80 who have high lipoprotein(a) levels.

  Recruiting at 130 sites Phase 2 Novartis · Huntsville, Alabama and 139 other locations · NCT05646381

• Predicting long-term outcomes for patients with aortic stenosis after valve intervention

  This study is trying to see how well patients with severe aortic stenosis do after they have heart valve surgery or a procedure, by following their health over a few years.

  Recruiting Uppsala University · Uppsala · NCT05629104

• Understanding the Aorta's Function and Structure

  This study looks at how the aorta works and its structure in both healthy people and those with aortic problems to see how these factors affect blood flow and overall health.

  Recruiting Heinrich-Heine University, Duesseldorf · Düsseldorf · NCT05603520

• Registry for patients undergoing Transcatheter Aortic Valve Replacement

  This study is tracking patients with severe aortic stenosis who are having a new heart valve procedure called TAVI to see how safe and effective it is for their health.

  Recruiting Federico II University · Naples · NCT05235555

• Using PCSK9 inhibitors to treat calcific aortic valve stenosis

  This study is testing if adding a new type of cholesterol-lowering medication to the treatment of adults with calcific aortic stenosis can help slow down the disease compared to just using standard statins.

  Recruiting Phase 3 Beijing Anzhen Hospital · Beijing, Beijing Municipality · NCT04968509

• Using angiotensin receptor blockers to treat aortic stenosis

  This study is testing if a common heart medication can help people with mild-to-moderate aortic stenosis by slowing its progression and improving heart function.

  Recruiting at 2 sites Phase 4 Institut universitaire de cardiologie et de pneumologie de Québec, University Laval · Québec, Quebec and 1 other locations · NCT04913870

• Comparing two techniques for aortic valve replacement in patients with bicuspid aortic stenosis

  This study tests two different ways to replace aortic valves in people with bicuspid aortic stenosis to see which method works better and has fewer complications.

  Recruiting at 3 sites Second Affiliated Hospital, Zhejiang University, School of Medicine · Bengbu, Anhui and 17 other locations · NCT04722796

• Comparing heart surgery and medical management for patients with aortic stenosis and coronary artery disease

  This study is testing whether combining heart surgery with medical treatment is better for patients who have both aortic stenosis and coronary artery disease.

  Recruiting at 71 sites University of British Columbia · Huntsville, Alabama and 71 other locations · NCT04634240

• Identifying biomarkers for Hypo-Attenuated Leaflet Thickening in heart patients

  This study is trying to find specific proteins in the blood that can help tell if older heart patients have a condition called Hypo-Attenuated Leaflet Thickening and see how these proteins change after treatment.

  Recruiting at 2 sites Phase 1 Massachusetts General Hospital · Boston, Massachusetts and 2 other locations · NCT04552275

• Using SMART watches to monitor patients after heart valve replacement

  This study tests if using a HUAWEI smartwatch to track heart rate, oxygen levels, and activity can help patients who have had heart valve replacement spot problems early and recover better.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT04454177

• Evaluation of a new transcatheter aortic valve system for severe aortic stenosis

  This study is testing a new heart valve system to see if it safely helps people with severe aortic stenosis feel better.

  Recruiting at 4 sites Shanghai MicroPort CardioFlow Medtech Co., Ltd. · Beijing, Beijing Municipality and 3 other locations · NCT04414878

• Avr Thrombosis Outcome in Aortic Valve Patients

  This study tests whether blood biomarkers can predict thrombosis risk in patients undergoing SAVR or TAVI to help tailor antithrombotic therapy.

  Recruiting East and North Hertfordshire NHS Trust · Stevenage, Hertforshire · NCT04234841

• Early valve replacement for asymptomatic severe aortic stenosis

  This study is testing if getting an early heart valve replacement helps people with severe aortic stenosis who don’t have symptoms live healthier and avoid hospital visits compared to just waiting and watching.

  Recruiting at 107 sites University of Leicester · Garran, Australian Capital Territory and 109 other locations · NCT04204915

• Comparing imaging methods for heart valve disease assessment

  This study is testing whether a new 3D heart imaging method is better than the traditional 2D method for checking how serious heart valve problems are in people with conditions like aortic stenosis and mitral valve regurgitation.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT04126018

• Investigating RNA profiles in heart failure and aortic stenosis

  This study is trying to see how certain RNA molecules in the blood and heart tissue of people with heart failure and aortic stenosis might help us understand their heart problems better and identify new ways to diagnose them.

  Recruiting at 2 sites IRCCS Policlinico S. Donato · San Donato Milanese, Milan and 1 other locations · NCT03268135

• Aortic valve replacement using SAPIEN 3 for failing bioprosthetic valves

  This study is testing if the SAPIEN 3 heart valves can safely help patients with failing bioprosthetic aortic valves feel better.

  Recruiting at 30 sites Edwards Lifesciences · Phoenix, Arizona and 50 other locations · NCT03003299

• Understanding heart function and biomarkers in aortic stenosis patients

  This study is trying to see how heart function, certain blood markers, and overall health can help predict how well patients with aortic stenosis do after getting their heart valve replaced.

  Recruiting Montreal Heart Institute · Montreal, Quebec · NCT02856620

• Improving quality of life after heart valve replacement

  This study looks at how people feel and do after getting a heart valve replacement to see if there are patterns that could help improve future treatments.

  Recruiting at 5 sites Sheba Medical Center · Jerusalem and 4 other locations · NCT02023060

NIH-funded research (22)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Investigating how stiffening of the aorta from elastin loss causes SVAS

  A new NIH grant is exploring why elastin loss leads to supravalvular aortic stenosis and how abnormal smooth muscle cell signaling causes the aorta to narrow in children.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11568641

• Risk prediction for aortic stenosis and how statins might help in adults 75 and older

  This grant seeks to identify which adults over 75 are at high risk for aortic valve disease and how statin therapy could influence that risk.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11429920

• AI-powered screening and monitoring for aortic stenosis in older adults

  A powerful new AI-based approach uses a simple heart rhythm test and a hand-held ultrasound to detect and monitor advanced aortic valve narrowing in people aged 65 and older.

  NIH research Yale University · New Haven, United States · NIH-11395442

• Linking normal aortic valve blood flow patterns to risk of aortic valve narrowing

  This grant studies how normal differences in how the aortic valve moves and carries blood might influence who develops aortic stenosis.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11377950

• Chronic Kidney Disease and Aortic Valve Disease: Understanding How Kidney Disease Influences Aortic Stenosis

  This grant looks at how chronic kidney disease may affect the progression of aortic stenosis and whether we can find ways to slow it down for adults with kidney issues.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11374552

• Advanced non-invasive imaging to understand aortic stenosis biology

  Aging adults with aortic stenosis may benefit from new imaging-based research to slow disease progression and reduce need for valve procedures.

  NIH research University of Virginia · Charlottesville, United States · NIH-11374488

• Blood protein patterns that track heart remodeling in aortic stenosis

  This project looks for blood protein signatures that show how the heart changes and recovers in people with aortic stenosis.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11257694

• Aortic valve calcium and risk of severe aortic stenosis in people over 75

  This project looks at how common calcium on the aortic valve is in people over 75 and which factors make it more likely to progress to severe aortic narrowing.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11252602

• Why muscle cells in the aorta may cause narrowing above the aortic valve

  Researchers are looking at whether changes in how aortic wall muscle cells sense stretch lead to supravalvular aortic stenosis in people with elastin (ELN) gene mutations.

  NIH research Washington University · Saint Louis, United States · NIH-11238014

• Role of TGF-beta Activation in Aortic Stenosis Progression

  A heart disease grant that studies how a blood-signal (TGF-beta) helps aortic valve disease progress, with potential implications for people living with aortic stenosis.

  NIH research Oklahoma Medical Research Foundation · Oklahoma City, United States · NIH-11234096

• Predicting heart changes to improve care for women with severe aortic stenosis

  This project uses advanced medical imaging and computer models to better predict how women's hearts remodel from severe aortic stenosis so care can be more personalized.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11175320

• AI to find and monitor aortic valve narrowing (aortic stenosis)

  This project uses AI on a single-lead ECG followed by AI-powered handheld ultrasound to find and track aortic valve narrowing in older adults.

  NIH research Yale University · New Haven, United States · NIH-11173796

• Understanding Aortic Valve Hardening with Advanced Imaging

  This project uses advanced imaging to better understand why heart valves harden, especially in older adults, hoping to find new ways to slow down or stop the condition.

  NIH research University of Virginia · Charlottesville, United States · NIH-11160526

• Understanding Heart Valve Narrowing in People with Kidney Disease

  This project aims to understand why a heart valve condition called aortic stenosis gets worse in people who also have kidney disease.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11129624

• Investigating aortic valve calcium and its risks in older adults

  This study is looking at how common aortic valve calcification is in people aged 75 and older and how it might lead to serious heart problems, with the goal of finding ways to help those at higher risk.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11045115

• Investigating blood proteins to understand heart changes in aortic stenosis

  This study is looking at certain proteins in the blood to see how they relate to heart changes in older adults with aortic stenosis, hoping to find ways to spot problems early and improve treatment options for patients.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11014048

• Understanding how changes in smooth muscle cells contribute to aortic narrowing in children

  This study is looking at how changes in a specific gene might affect the aorta in children with supravalvular aortic stenosis (SVAS), a condition that can lead to serious heart problems, to help find new ways to treat it since there aren’t any medicines available right now.

  NIH research Washington University · Saint Louis, United States · NIH-10980564

• Using AI to improve detection and monitoring of aortic stenosis

  This study is exploring how artificial intelligence can help doctors find and keep track of aortic stenosis, a heart condition that mainly affects older adults, by using easy-to-use tools like simple heart tests and handheld ultrasounds to spot serious cases more accurately and quickly.

  NIH research Yale University · New Haven, United States · NIH-10944019

• Using advanced MRI to assess severe low-gradient aortic stenosis

  This study is looking at a special type of MRI to help doctors better understand and diagnose patients with low-gradient aortic stenosis, especially when their heart tests and symptoms don’t seem to match, so they can provide more personalized treatment options.

  NIH research University of Louisville · Louisville, United States · NIH-10912050

• Investigating the causes of aortic stenosis using advanced imaging techniques

  This study is looking at aortic stenosis, a heart valve condition that often affects older adults, to better understand how it develops and to find new ways to treat it, which could help improve care for patients like you.

  NIH research University of Virginia · Charlottesville, United States · NIH-10892832

• Understanding how women's bodies respond to severe aortic stenosis to improve treatment outcomes

  This study is looking at how severe aortic stenosis affects women differently than men, with the hope of creating better, personalized treatment plans for women to improve their heart valve replacement procedures.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-10870456

• Investigating the link between chronic kidney disease and the progression of aortic stenosis.

  This study is looking at how chronic kidney disease affects the worsening of a heart condition called aortic stenosis, and it's for people with kidney issues who want to understand their heart health better and find new ways to manage their condition.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-10844441

Related topics

Quick answers

How many Aortic Stenosis clinical trials are recruiting right now?

55, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 31 countries. The most sites are in United States (14 trials), China (9 trials), Italy (8 trials), Canada (7 trials), Germany (7 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 2, Phase 2: 1, Phase 3: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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