Risk prediction for aortic stenosis and how statins might help in adults 75 and older
Official title: Risk Prediction for aortic stenosis and the impact of statin therapy among adults >75 years old in the PREVENTABLE trial
Funded at Johns Hopkins University · NIH-11429920 · Data updated 2026-11-12
This grant seeks to identify which adults over 75 are at high risk for aortic valve disease and how statin therapy could influence that risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 1, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $632,235 |
| NIH project number | 1R01HL188732-01 |
| Project ID | NIH-11429920 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults aged 75 and older who have or are at risk for calcific aortic valve disease and are being considered for lipid-lowering therapy.
✕Less likely to help
The findings may be less directly helpful for younger individuals or those without risk factors for aortic valve disease.
What this research studies
If you are 75 or older and have concerns about your heart valves, this project aims to create a better way to spot those at high risk for aortic stenosis due to calcification. The research will examine how cholesterol-lowering meds like statins could impact the progression of valve disease and related risks such as dementia or stroke. By using data from real-world adults and focusing on age-specific factors, the study hopes to develop practical risk-prediction methods that could guide future prevention choices. The team at Johns Hopkins plans to analyze patterns in lipids, inflammation, and valve calcium to identify potential intervention points.
Why it matters
Potential benefit: A clearer picture of who is at high risk could lead to earlier, personalized prevention strategies and better management of valve health in older adults.
How similar studies have gone: Previous analyses hint that lipid-lowering therapy might influence valve disease risk, but robust, age-specific evidence is lacking.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Whelton, Seamus Paul — Johns Hopkins University
- Study coordinator: Whelton, Seamus Paul
Related research
Other NIH-funded projects on the same topics.
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Investigating how stiffening of the aorta from elastin loss causes SVAS
A new NIH grant is exploring why elastin loss leads to supravalvular aortic stenosis and how abnormal smooth muscle cell signaling causes the aorta to narrow in children.
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AI-powered screening and monitoring for aortic stenosis in older adults
A powerful new AI-based approach uses a simple heart rhythm test and a hand-held ultrasound to detect and monitor advanced aortic valve narrowing in people aged 65 and older.
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Linking normal aortic valve blood flow patterns to risk of aortic valve narrowing
This grant studies how normal differences in how the aortic valve moves and carries blood might influence who develops aortic stenosis.
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Chronic Kidney Disease and Aortic Valve Disease: Understanding How Kidney Disease Influences Aortic Stenosis
This grant looks at how chronic kidney disease may affect the progression of aortic stenosis and whether we can find ways to slow it down for adults with kidney issues.
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Advanced non-invasive imaging to understand aortic stenosis biology
Aging adults with aortic stenosis may benefit from new imaging-based research to slow disease progression and reduce need for valve procedures.
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Blood protein patterns that track heart remodeling in aortic stenosis
This project looks for blood protein signatures that show how the heart changes and recovers in people with aortic stenosis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.