Advanced non-invasive imaging to understand aortic stenosis biology
Official title: Advanced Non-invasive Imaging in the Investigation of Aortic Stenosis Pathobiology
Funded at University of Virginia · NIH-11374488 · Data updated 2026-11-12
Aging adults with aortic stenosis may benefit from new imaging-based research to slow disease progression and reduce need for valve procedures.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | September 1, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $659,193 |
| NIH project number | 5R01HL165422-05 |
| Project ID | NIH-11374488 on NIH RePORTER |
Who could benefit from this research
✓Could help
Older adults with aortic stenosis or at risk of AS who can undergo non-invasive imaging and standard echocardiography.
✕Less likely to help
Patients without AS symptoms or those unable to undergo imaging procedures may derive limited direct benefit.
What this research studies
This project uses advanced non-invasive imaging and echocardiography to study how valve cell behavior and calcification drive aortic stenosis in older adults. By looking at the aortic root in living animals and translating findings to humans, researchers aim to map the signaling pathways that cause valve deterioration. The work builds on prior findings about platelets, von Willebrand factor, and myofibroblast transformation to identify potential targets for therapy. The goal is to uncover mechanisms that could lead to medical treatments to slow or halt progression.
Why it matters
Potential benefit: If successful, the research could reveal targets for drugs that slow aortic stenosis and reduce the need for valve replacement.
How similar studies have gone: Previous work demonstrated a link between platelet–VWF interactions and valve pathology, suggesting potential translational relevance.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Lindner, Jonathan R — University of Virginia
- Study coordinator: Lindner, Jonathan R
Related research
Other NIH-funded projects on the same topics.
-
Investigating how stiffening of the aorta from elastin loss causes SVAS
A new NIH grant is exploring why elastin loss leads to supravalvular aortic stenosis and how abnormal smooth muscle cell signaling causes the aorta to narrow in children.
-
Risk prediction for aortic stenosis and how statins might help in adults 75 and older
This grant seeks to identify which adults over 75 are at high risk for aortic valve disease and how statin therapy could influence that risk.
-
AI-powered screening and monitoring for aortic stenosis in older adults
A powerful new AI-based approach uses a simple heart rhythm test and a hand-held ultrasound to detect and monitor advanced aortic valve narrowing in people aged 65 and older.
-
Linking normal aortic valve blood flow patterns to risk of aortic valve narrowing
This grant studies how normal differences in how the aortic valve moves and carries blood might influence who develops aortic stenosis.
-
Chronic Kidney Disease and Aortic Valve Disease: Understanding How Kidney Disease Influences Aortic Stenosis
This grant looks at how chronic kidney disease may affect the progression of aortic stenosis and whether we can find ways to slow it down for adults with kidney issues.
-
Blood protein patterns that track heart remodeling in aortic stenosis
This project looks for blood protein signatures that show how the heart changes and recovers in people with aortic stenosis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.