Blood protein patterns that track heart remodeling in aortic stenosis
Circulating Proteomics to Phenotype the Development and Reversal of Myocardial Remodeling in Aortic Stenosis
This project looks for blood protein signatures that show how the heart changes and recovers in people with aortic stenosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11257694 on NIH RePORTER |
What this research studies
You would donate blood and undergo heart imaging so researchers can measure many circulating proteins and link them to heart structure and function. The team will compare protein patterns across people with mild to severe aortic stenosis and before and after valve replacement procedures like TAVR. They will use bioinformatics to define signatures that mark harmful remodeling or recovery. Promising signatures will be tested in larger groups to see if they predict who benefits from earlier intervention.
Who could benefit from this research
Good fit: Adults with aortic stenosis at any stage, including those being monitored for progression or being considered for surgical or transcatheter valve replacement, are the ideal candidates.
Not a fit: People without aortic valve disease or whose heart problems are due to other conditions are unlikely to benefit directly from this work.
Why it matters
Potential benefit: If successful, this could help identify patients who need earlier valve treatment and reduce long-term heart damage and heart failure after valve procedures.
How similar studies have performed: Small preliminary work (including a 115-person cohort) found encouraging proteomic signatures, but larger validation is still needed.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Lindman, Brian Richard — Vanderbilt University Medical Center
- Study coordinator: Lindman, Brian Richard
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.