Blood protein patterns that track heart remodeling in aortic stenosis
Official title: Circulating Proteomics to Phenotype the Development and Reversal of Myocardial Remodeling in Aortic Stenosis
Funded at Vanderbilt University Medical Center · NIH-11257694 · Data updated 2026-11-12
This project looks for blood protein signatures that show how the heart changes and recovers in people with aortic stenosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | April 1, 2023 |
| Project end | January 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $769,658 |
| NIH project number | 5R01HL164526-04 |
| Project ID | NIH-11257694 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with aortic stenosis at any stage, including those being monitored for progression or being considered for surgical or transcatheter valve replacement, are the ideal candidates.
✕Less likely to help
People without aortic valve disease or whose heart problems are due to other conditions are unlikely to benefit directly from this work.
What this research studies
You would donate blood and undergo heart imaging so researchers can measure many circulating proteins and link them to heart structure and function. The team will compare protein patterns across people with mild to severe aortic stenosis and before and after valve replacement procedures like TAVR. They will use bioinformatics to define signatures that mark harmful remodeling or recovery. Promising signatures will be tested in larger groups to see if they predict who benefits from earlier intervention.
Why it matters
Potential benefit: If successful, this could help identify patients who need earlier valve treatment and reduce long-term heart damage and heart failure after valve procedures.
How similar studies have gone: Small preliminary work (including a 115-person cohort) found encouraging proteomic signatures, but larger validation is still needed.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Lindman, Brian Richard — Vanderbilt University Medical Center
- Study coordinator: Lindman, Brian Richard
Related research
Other NIH-funded projects on the same topics.
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Investigating how stiffening of the aorta from elastin loss causes SVAS
A new NIH grant is exploring why elastin loss leads to supravalvular aortic stenosis and how abnormal smooth muscle cell signaling causes the aorta to narrow in children.
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Risk prediction for aortic stenosis and how statins might help in adults 75 and older
This grant seeks to identify which adults over 75 are at high risk for aortic valve disease and how statin therapy could influence that risk.
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AI-powered screening and monitoring for aortic stenosis in older adults
A powerful new AI-based approach uses a simple heart rhythm test and a hand-held ultrasound to detect and monitor advanced aortic valve narrowing in people aged 65 and older.
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Linking normal aortic valve blood flow patterns to risk of aortic valve narrowing
This grant studies how normal differences in how the aortic valve moves and carries blood might influence who develops aortic stenosis.
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Chronic Kidney Disease and Aortic Valve Disease: Understanding How Kidney Disease Influences Aortic Stenosis
This grant looks at how chronic kidney disease may affect the progression of aortic stenosis and whether we can find ways to slow it down for adults with kidney issues.
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Advanced non-invasive imaging to understand aortic stenosis biology
Aging adults with aortic stenosis may benefit from new imaging-based research to slow disease progression and reduce need for valve procedures.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.