Understanding Heart Valve Narrowing in People with Kidney Disease
Official title: Chronic Renal Insufficiency and Silent Progression of Aortic Stenosis (CRISP-AS)
Funded at Beth Israel Deaconess Medical Center · NIH-11129624 · Data updated 2026-11-12
This project aims to understand why a heart valve condition called aortic stenosis gets worse in people who also have kidney disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $763,572 |
| NIH project number | 5R01HL169517-03 |
| Project ID | NIH-11129624 on NIH RePORTER |
Who could benefit from this research
✓Could help
This research is relevant for adults, especially those aged 21-74 with chronic kidney disease, who are at risk for or have aortic stenosis.
✕Less likely to help
Patients who do not have chronic kidney disease or aortic stenosis may not directly benefit from the specific findings of this particular research.
What this research studies
Aortic stenosis is a common and serious heart valve problem that can worsen over time, often requiring surgery. Unfortunately, many people cannot undergo surgery, and there are currently no medications to slow its progression. This research focuses on individuals with chronic kidney disease, who frequently experience a faster worsening of aortic stenosis. By carefully examining detailed health information from large existing groups of people with kidney disease, researchers hope to uncover new factors that contribute to this progression. The ultimate goal is to find new ways to prevent or slow down the worsening of aortic stenosis, especially for those also managing kidney health.
Why it matters
Potential benefit: If successful, this work could lead to new medical treatments to slow or prevent the progression of aortic stenosis, particularly for individuals with kidney disease.
How similar studies have gone: While aortic stenosis has been studied for decades, there are currently no proven medical therapies to slow its progression, making this approach to identify risk factors novel.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Strom, Jordan Blair — Beth Israel Deaconess Medical Center
- Study coordinator: Strom, Jordan Blair
Related research
Other NIH-funded projects on the same topics.
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Chronic Kidney Disease and Aortic Valve Disease: Understanding How Kidney Disease Influences Aortic Stenosis
This grant looks at how chronic kidney disease may affect the progression of aortic stenosis and whether we can find ways to slow it down for adults with kidney issues.
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Investigating the link between chronic kidney disease and the progression of aortic stenosis.
This study is looking at how chronic kidney disease affects the worsening of a heart condition called aortic stenosis, and it's for people with kidney issues who want to understand their heart health better and find new ways to manage their condition.
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Investigating how stiffening of the aorta from elastin loss causes SVAS
A new NIH grant is exploring why elastin loss leads to supravalvular aortic stenosis and how abnormal smooth muscle cell signaling causes the aorta to narrow in children.
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Risk prediction for aortic stenosis and how statins might help in adults 75 and older
This grant seeks to identify which adults over 75 are at high risk for aortic valve disease and how statin therapy could influence that risk.
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AI-powered screening and monitoring for aortic stenosis in older adults
A powerful new AI-based approach uses a simple heart rhythm test and a hand-held ultrasound to detect and monitor advanced aortic valve narrowing in people aged 65 and older.
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Chronic Renal Insufficiency Cohort: Phase 5 SDCC Support
This grant funds a central coordinating center to oversee a long-term study of adults with reduced kidney function and related health outcomes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.