Understanding Heart Valve Narrowing in People with Kidney Disease
Chronic Renal Insufficiency and Silent Progression of Aortic Stenosis (CRISP-AS)
['FUNDING_R01'] · BETH ISRAEL DEACONESS MEDICAL CENTER · NIH-11129624
This project aims to understand why a heart valve condition called aortic stenosis gets worse in people who also have kidney disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BETH ISRAEL DEACONESS MEDICAL CENTER (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11129624 on ClinicalTrials.gov |
What this research studies
Aortic stenosis is a common and serious heart valve problem that can worsen over time, often requiring surgery. Unfortunately, many people cannot undergo surgery, and there are currently no medications to slow its progression. This research focuses on individuals with chronic kidney disease, who frequently experience a faster worsening of aortic stenosis. By carefully examining detailed health information from large existing groups of people with kidney disease, researchers hope to uncover new factors that contribute to this progression. The ultimate goal is to find new ways to prevent or slow down the worsening of aortic stenosis, especially for those also managing kidney health.
Who could benefit from this research
Good fit: This research is relevant for adults, especially those aged 21-74 with chronic kidney disease, who are at risk for or have aortic stenosis.
Not a fit: Patients who do not have chronic kidney disease or aortic stenosis may not directly benefit from the specific findings of this particular research.
Why it matters
Potential benefit: If successful, this work could lead to new medical treatments to slow or prevent the progression of aortic stenosis, particularly for individuals with kidney disease.
How similar studies have performed: While aortic stenosis has been studied for decades, there are currently no proven medical therapies to slow its progression, making this approach to identify risk factors novel.
Where this research is happening
BOSTON, UNITED STATES
- BETH ISRAEL DEACONESS MEDICAL CENTER — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: STROM, JORDAN BLAIR — BETH ISRAEL DEACONESS MEDICAL CENTER
- Study coordinator: STROM, JORDAN BLAIR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.