Condition

Aortic Aneurysm clinical trials and research

• 24Clinical trials
• 68NIH research projects
• 18Countries

Newest Aortic Aneurysm clinical trials

All recruiting trials (24)

• Physician-modified endografts for aortic disease in high-risk patients

  This study tests a physician-modified Terumo Treo abdominal stent-graft to see if it can safely treat large aortic aneurysms in patients who are high-risk for open surgery.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT07611968

• Using AI to measure aortic size from CT scans

  This project will test whether an AI tool called Aorta AIM can automatically measure the aorta on CT scans for adults who have or are being checked for aortic aneurysms.

  Recruiting Aiatella Oy · Chapel Hill, North Carolina and 2 other locations · NCT07438327

• Measuring the shape and strength of the ascending aorta in patients having heart surgery

  We will test whether direct measurements of the aortic wall's mechanical properties taken during heart surgery can better characterize rupture or dissection risk in people with ascending aortic aneurysm by comparing them to patients undergoing heart transplantation without known aortic disease.

  Recruiting Fondazione IRCCS Policlinico San Matteo di Pavia · Pavia, Lombardy · NCT07422129

• Rapidlink device for repairing aortic arch branch vessels during open thoracic aorta surgery

  This study will test whether the Rapidlink device can help surgeons repair or replace the arteries branching from the aortic arch during open surgery for thoracic aortic disease.

  Recruiting at 7 sites Vascutek Ltd. · Los Angeles, California and 20 other locations · NCT07078383

• Using modified endovascular grafts to treat complex aortic aneurysms

  This study is testing if specially modified grafts can safely repair complex aortic aneurysms in high-risk patients who can’t have regular surgery.

  Recruiting Hartford Hospital · Hartford, Connecticut · NCT06834607

• Understanding exercise effects on aortic aneurysm patients

  This study is testing how exercise affects people with aortic aneurysms to help find safe activity levels that could improve their health.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06789809

• Using mesh to prevent hernias after aortic aneurysm surgery

  This study is testing if using a special mesh during surgery can help prevent hernias in patients who have had surgery for an aortic aneurysm.

  Recruiting Hôpital Fribourgeois · Villars-sur-Glâne · NCT06762561

• Radiation-free FEVAR with LumiGuide image guidance

  This study will test whether using LumiGuide instead of standard fluoroscopy cuts X‑ray time during fenestrated endovascular aortic repair for adults who need visceral artery incorporation.

  Recruiting at 8 sites Philips Clinical & Medical Affairs Global · Birmingham, Alabama and 10 other locations · NCT06549348

• Evaluating a new aortic endograft for treating thoracoabdominal aneurysms

  This study is testing a new type of aortic stent to see if it’s a safer and more effective option for high-risk patients with thoracoabdominal aneurysms compared to traditional surgery.

  Recruiting Dartmouth-Hitchcock Medical Center · Lebanon, New Hampshire · NCT06501872

• Using a new device to treat aortic aneurysms

  This study is testing a new device to see if it can safely treat aortic aneurysms near the kidney arteries in patients who can't have standard surgeries.

  Recruiting University of Missouri-Columbia · Columbia, Missouri · NCT06411990

• Evaluating a new tool for branched endovascular aortic repair

  This study is testing a new stent design for aortic repair to see if it works well and is easy to use for patients undergoing this treatment.

  Recruiting University Hospital Muenster · Münster · NCT06374355

• Analyzing activities during aortic aneurysm ruptures

  This study looks at what people were doing when their aortic aneurysm ruptured to see if certain activities or stress levels can help guide safer behaviors for others with similar conditions.

  Recruiting University Hospital Augsburg · Augsburg · NCT06365138

• Exploring kinocardiography for diagnosing aortic valve disease and aneurysms

  This study is testing if kinocardiography can help doctors better diagnose aortic valve disease and aortic aneurysms in patients.

  Recruiting Université Libre de Bruxelles · Brussels · NCT06286358

• Using 3D printed models to plan surgery for aortic aneurysms

  This study is testing if using 3D printed models of aortic blood vessels can help surgeons plan surgeries better for people with aortic aneurysms and improve their outcomes.

  Recruiting Fu Jen Catholic University · New Taipei City · NCT06147024

• Evaluating a new device for aortic repair

  This study is testing a new custom-made device for repairing certain aortic problems to see if it works well and is easy to use for patients needing this treatment.

  Recruiting University Hospital Muenster · Münster · NCT06059053

• Comparing quality of life after different types of aortic aneurysm repair

  This study looks at how different types of surgery for abdominal aortic aneurysms affect the quality of life for patients over three years.

  Recruiting Karolinska University Hospital · Stockholm · NCT05774938

• Improving recovery after surgery with intravenous iron treatment

  This study tests if giving intravenous iron to patients who lose a lot of blood during major surgeries can help them recover better and need fewer blood transfusions.

  Recruiting Phase 3 Uppsala University Hospital · Uppsala, Sverige · NCT05744219

• Understanding the Aorta's Function and Structure

  This study looks at how the aorta works and its structure in both healthy people and those with aortic problems to see how these factors affect blood flow and overall health.

  Recruiting Heinrich-Heine University, Duesseldorf · Düsseldorf · NCT05603520

• Improving brain protection during aortic arch surgery

  This study is testing a new way to monitor brain health during aortic arch surgery to see if it can help prevent brain problems after the operation.

  Recruiting Barts & The London NHS Trust · London · NCT04966247

• Evaluation of the NEXUS Aortic Arch Stent Graft System for treating aortic conditions

  This study is testing a new stent graft system to see if it can safely and effectively treat certain aortic problems in patients with specific conditions.

  Recruiting at 25 sites Endospan Ltd. · Birmingham, Alabama and 31 other locations · NCT04471909

• Precision medicine for heritable thoracic aortic disease

  This study is trying to learn more about genetic factors in people with heritable thoracic aortic disease to help doctors better predict risks and manage their care.

  Recruiting at 20 sites The University of Texas Health Science Center, Houston · Newport Beach, California and 19 other locations · NCT04005976

• Improving Aortic Endovascular Repair with Personalized Biomechanical Modeling

  This study is testing a new computer program that helps doctors perform safer and more effective surgeries for abdominal aortic aneurysms by using personalized imaging of each patient's blood vessels.

  Recruiting Centre hospitalier de l'Université de Montréal (CHUM) · Montreal, Quebec · NCT03481075

• Identifying biomarkers for aortic aneurysm and dissection

  This study is trying to find specific markers in the blood that can help doctors diagnose and predict outcomes for people with aortic aneurysm and aortic dissection.

  Recruiting Beijing Institute of Heart, Lung and Blood Vessel Diseases · Beijing, Beijing Municipality · NCT03233087

• Project to improve cardiovascular health through biobanking

  This project is collecting blood samples and health information from people with heart diseases and healthy individuals to help researchers learn more about heart health and its genetic factors.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT02306200

NIH-funded research (newest 40 of 68)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Biomarker clues from animal and computer models to predict when the ascending aorta could fail

  Researchers will combine animal studies and computer models to find biological clues that help predict dangerous changes in the ascending aorta for people with aortic aneurysm.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11465647

• How the small regulator miR-146a affects abdominal aortic aneurysm

  This project aims to see if boosting a natural genetic regulator called miR-146a can help slow or prevent growth and rupture of abdominal aortic aneurysms in people with this condition.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11453518

• MOF’s role in weakening the aorta and stopping aneurysm growth

  Scientists are studying how a molecule called MOF and inflammatory signals affect abdominal aortic aneurysms to find ways to slow or stop their enlargement.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11424572

• Endovascular Suturing Device to Improve Endograft Fixation in Abdominal Aortic Aneurysm

  A new device aims to better secure endografts during EVAR for abdominal aortic aneurysm to reduce future repairs.

  NIH research Vesteck, INC · Malvern, UNITED STATES · NIH-11414951

• Sexual differences in thoracic aortic aneurysm biology

  A study to understand why men and women experience thoracic aortic aneurysms differently, with a focus on human tissue and biology.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11406202

• Triglyceride-rich lipoproteins and abdominal aortic aneurysm growth

  A study exploring how fats in the blood (TRLs) influence the growth of abdominal aortic aneurysms to find non-surgical ways to protect against rupture, especially in people aged 65 and older.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11389655

• Using genetics to uncover how abdominal aortic aneurysms develop

  A research team will study how genetic differences influence abdominal aortic aneurysm to help with earlier prevention and better treatment.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11382092

• Phospholipid-based nanotherapies to treat abdominal aortic aneurysm

  A new nanoparticle treatment is being developed to slow or stop the growth of abdominal aortic aneurysms in adults.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11374518

• Vascular smooth muscle cell ferroptosis and abdominal aortic aneurysm

  A study to understand how a specific type of cell death in blood vessel walls may drive abdominal aortic aneurysm and if new targets could prevent rupture.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11373578

• Targeting the Mineralocorticoid Receptor in Blood Vessel Cells to Fight Abdominal Aortic Aneurysm in Women

  Researchers are testing a potential treatment strategy that targets a hormone receptor in blood vessels to slow or prevent abdominal aortic aneurysm in women.

  NIH research University of Kentucky · Lexington, United States · NIH-11364929

• PERK-blocking treatments to slow or stop abdominal aortic aneurysm progression

  Finding out whether medicines that block a cell stress pathway called PERK can protect the aorta in people with abdominal aortic aneurysm.

  NIH research University of Virginia · Charlottesville, United States · NIH-11348188

• New tiny drugs to keep the aorta strong in Marfan syndrome

  A small study tests new compounds that could keep the aorta from dilating and prevent serious complications in people with Marfan syndrome.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11337519

• PAR2 role in abdominal aortic aneurysm development

  Researchers are studying how a specific receptor (PAR2) in blood vessels might contribute to the development and progression of abdominal aortic aneurysms, with potential pathways to new treatments for people with the condition.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11332797

• Could vaping increase abdominal aortic aneurysm risk across generations

  This project looks at whether parents' vaping or nicotine exposure can cause biological changes that make their children more likely to develop abdominal aortic aneurysms.

  NIH research Palo Alto Veterans Instit for Research · Palo Alto, United States · NIH-11332766

• Enhanced biochemical monitoring for aortic aneurysm disease

  A new approach uses blood-based biomarkers to diagnose, locate, and track aortic aneurysms so doctors can better time treatment.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11330287

• Oxidative changes and aortic aneurysms in Marfan syndrome

  This work looks at whether reversing a chemical modification that turns off the enzyme Sirt1 in aortic wall cells can help prevent dangerous aortic enlargement in people with Marfan syndrome.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11328829

• Understanding how protein quality control affects abdominal aortic aneurysm (AAA)

  Researchers are studying how the cell’s protein-cleanup system may drive or protect against abdominal aortic aneurysm, with the goal of finding new ways to prevent progression.

  NIH research Augusta University · Augusta, United States · NIH-11318959

• Deciding when to stop yearly CT scans after repair of an abdominal aortic aneurysm

  This project compares keeping yearly CT scans versus less frequent imaging to help Veterans who had endovascular aortic aneurysm repair avoid unnecessary risks.

  NIH research White River Junction VA Medical Center · White River Junction, UNITED STATES · NIH-11311794

• PCSK9 inhibitors and abdominal aortic aneurysm growth

  A new study asks whether lowering LDL cholesterol with PCSK9 inhibitors can slow the growth of abdominal aortic aneurysms in older adults.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11309600

• GCN2 and amino acid restriction in abdominal aortic aneurysm

  This project looks at how a cellular stress pathway called GCN2, activated by limiting amino acids, might help slow or prevent abdominal aortic aneurysm in people at risk.

  NIH research Northwestern University · Chicago, United States · NIH-11295475

• Targeted treatments to slow or prevent abdominal aortic aneurysm growth

  Looks at whether blocking a protein called BRD4 in artery muscle cells and delivering therapy directly to the aorta can slow or prevent abdominal aortic aneurysm in people at risk.

  NIH research University of Virginia · Charlottesville, United States · NIH-11295470

• What makes abdominal aortic aneurysms grow and weaken

  Researchers are looking at why the wall of the belly artery weakens and can burst in people with abdominal aortic aneurysms by studying cell survival and the artery's outer layer.

  NIH research University of Missouri-Columbia · Columbia, United States · NIH-11289478

• Gene editing to stop aortic aneurysms in Marfan syndrome

  This project uses precise gene-editing to fix or compensate for faulty FBN1 genes in adults with Marfan syndrome to help prevent dangerous aortic enlargement and tearing.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11282721

• Using AI and 3D CT scans to predict rupture risk for thoracic aortic aneurysms

  This project uses machine learning plus 3D CT scans to help identify adults with thoracic aortic aneurysms—especially smaller ones—who may be at higher risk of rupture.

  NIH research University of Miami Coral Gables · Coral Gables, United States · NIH-11260144

• Cell mechanics and gene switches in thoracic aortic aneurysm

  This project looks at how changes in the way aorta cells sense force and control genes can lead to dangerous enlargement of the chest aorta, aiming to help people with or at risk for thoracic aortic aneurysms.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11245710

• Genes behind abdominal aortic aneurysm

  Researchers will use large-scale genetic and tissue data to find genes and biological signals that could help prevent or treat abdominal aortic aneurysms in people at risk.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11161577

• Understanding the causes and treatments for thoracic aortic aneurysm

  This study is looking into how thoracic aortic aneurysms develop in people with Marfan syndrome, with the goal of finding new ways to treat this condition, and it involves testing different medications on animal models to see how they affect aortic health.

  NIH research University of Kentucky · Lexington, United States · NIH-11136787

• Investigating how redox signaling affects aortic aneurysms in Marfan syndrome

  This study is looking at how certain chemical signals in the body might contribute to aortic aneurysms in people with Marfan syndrome, with the goal of finding new ways to prevent or treat these serious heart issues.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11133210

• Using specialized cells to find new treatments for aortic aneurysms

  This study is looking at how a special protein called Sirt1 can help prevent dangerous aortic aneurysms, especially for people with conditions like Marfan syndrome, by testing new drugs that might make this protein work better to keep your heart healthy.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11122798

• Investigating how amino acid starvation affects abdominal aortic aneurysms

  This study is looking at how cutting back on certain amino acids in your diet might help slow down the growth of abdominal aortic aneurysms in older adults, and it aims to find new, non-surgical ways to keep your aorta healthy.

  NIH research Northwestern University at Chicago · Chicago, United States · NIH-11122292

• Investigating a receptor's role in abdominal aortic aneurysms

  This study is looking at how a specific protein called PAR2 affects the growth and worsening of abdominal aortic aneurysms, with the goal of finding new treatment options for patients beyond just surgery.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11121653

• Finding better warning signs for problems in the upper aorta (ascending aortic aneurysm)

  Researchers are combining mouse experiments, computer simulations, and patient scans to find sets of markers that could warn people with ascending aortic aneurysms about the risk of rapid growth, tearing, or rupture.

  NIH research Washington University · Saint Louis, United States · NIH-11117068

• Targeting inflammation to prevent abdominal aortic aneurysm progression

  This study is looking at how inflammation in certain cells affects the growth of abdominal aortic aneurysms and is exploring a protein called BRD4 to find new ways to help prevent these aneurysms from getting worse, which could lead to better treatments for people at risk.

  NIH research University of Virginia · Charlottesville, United States · NIH-11115830

• Understanding a Protein's Role in Abdominal Aortic Aneurysms

  This research looks into a specific protein called BAF60c to better understand how abdominal aortic aneurysms develop, hoping to find new ways to treat them.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11112304

• Understanding Cell Signals in Aortic Aneurysms

  This research explores how specific cell signals contribute to the weakening of blood vessel walls in aortic aneurysms.

  NIH research University of Rochester · Rochester, United States · NIH-11110382

• Platelets and abdominal aortic aneurysm growth

  Looking at whether blocking a specific platelet receptor can help slow aneurysm growth in older adults with abdominal aortic aneurysms.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11109654

• How e-cigarettes may affect the risk of abdominal aortic aneurysms across generations

  This study is looking at how using e-cigarettes and being exposed to nicotine might lead to a serious condition called abdominal aortic aneurysms (AAAs), and it aims to understand how these factors could cause changes in genes that might affect not just the person using e-cigarettes, but also their children.

  NIH research Palo Alto Veterans Instit for Research · Palo Alto, United States · NIH-11105516

• Understanding Cell Death in Abdominal Aortic Aneurysms

  This research explores how a specific type of cell death in blood vessel walls might contribute to abdominal aortic aneurysms, hoping to find new ways to prevent or treat this serious condition.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11097177

• Improving blood tests for monitoring aortic aneurysms

  This study is working on new blood tests to help people with aortic aneurysms get diagnosed and monitored more easily and affordably, instead of relying on expensive imaging tests.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11092861

• New Nanoparticle Treatment for Abdominal Aortic Aneurysm

  This research explores a new way to deliver anti-inflammatory medicine using tiny particles to help patients with abdominal aortic aneurysms.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11090423

Related topics

Quick answers

How many Aortic Aneurysm clinical trials are recruiting right now?

24, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 18 countries. The most sites are in United States (11 trials), Germany (5 trials), United Kingdom (4 trials), Belgium (3 trials), Netherlands (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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