Chronic Kidney Disease and Aortic Valve Disease: Understanding How Kidney Disease Influences Aortic Stenosis
Official title: Chronic Renal Insufficiency and Silent Progression of Aortic Stenosis (CRISP-AS)
Funded at Beth Israel Deaconess Medical Center · NIH-11374552 · Data updated 2026-11-12
This grant looks at how chronic kidney disease may affect the progression of aortic stenosis and whether we can find ways to slow it down for adults with kidney issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $692,911 |
| NIH project number | 5R01HL169517-04 |
| Project ID | NIH-11374552 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with chronic kidney disease who have or are at risk for aortic stenosis and have extensive baseline imaging and clinical data available.
✕Less likely to help
Patients without CKD or without concurrent aortic valve disease may not directly benefit from this research.
What this research studies
The project uses data from large kidney disease and general cardiovascular cohorts to study how aortic stenosis progresses over time in adults with CKD. Researchers will examine heart imaging and health data to identify factors that speed up valve calcification and decline. By leveraging detailed, long-term follow-up from existing studies, the team aims to uncover mechanisms that could lead to new treatments to slow AS progression in at-risk adults. The work may help doctors better predict who will worsen and tailor management before severe disease develops.
Why it matters
Potential benefit: If successful, the findings could lead to earlier identification of high-risk patients and inform strategies to slow aortic valve progression, potentially delaying the need for valve replacement.
How similar studies have gone: Previous cohorts have shown that CKD is associated with faster valvular calcification, supporting the relevance of this approach, though direct interventions remain to be proven.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Strom, Jordan Blair — Beth Israel Deaconess Medical Center
- Study coordinator: Strom, Jordan Blair
Related research
Other NIH-funded projects on the same topics.
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Understanding Heart Valve Narrowing in People with Kidney Disease
This project aims to understand why a heart valve condition called aortic stenosis gets worse in people who also have kidney disease.
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Investigating the link between chronic kidney disease and the progression of aortic stenosis.
This study is looking at how chronic kidney disease affects the worsening of a heart condition called aortic stenosis, and it's for people with kidney issues who want to understand their heart health better and find new ways to manage their condition.
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Investigating how stiffening of the aorta from elastin loss causes SVAS
A new NIH grant is exploring why elastin loss leads to supravalvular aortic stenosis and how abnormal smooth muscle cell signaling causes the aorta to narrow in children.
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Risk prediction for aortic stenosis and how statins might help in adults 75 and older
This grant seeks to identify which adults over 75 are at high risk for aortic valve disease and how statin therapy could influence that risk.
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AI-powered screening and monitoring for aortic stenosis in older adults
A powerful new AI-based approach uses a simple heart rhythm test and a hand-held ultrasound to detect and monitor advanced aortic valve narrowing in people aged 65 and older.
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Chronic Renal Insufficiency Cohort: Phase 5 SDCC Support
This grant funds a central coordinating center to oversee a long-term study of adults with reduced kidney function and related health outcomes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.