Role of TGF-beta Activation in Aortic Stenosis Progression
Official title: The Role of TGF-beta Activation and Signaling in Aortic Stenosis Progression
Funded at Oklahoma Medical Research Foundation · NIH-11234096 · Data updated 2026-11-12
A heart disease grant that studies how a blood-signal (TGF-beta) helps aortic valve disease progress, with potential implications for people living with aortic stenosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | April 1, 2020 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $786,750 |
| NIH project number | 2R01HL148123-05A1 |
| Project ID | NIH-11234096 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with aortic stenosis or related valve disease, especially in older adults, may be relevant for future translational or clinical follow-up.
✕Less likely to help
People without aortic valve disease or those not eligible for future translational studies may not benefit directly.
What this research studies
This project looks at how mechanical forces in the heart activate TGF-beta, which may drive worsening aortic stenosis and related heart failure. Researchers use mouse models that develop aortic stenosis and anemia-induced changes to understand the pathways that lead to valve disease and, potentially, acquired von Willebrand syndrome. They are exploring how activated TGF-beta signaling inside valve cells correlates with disease progression and symptoms. The study aims to uncover mechanisms that could later guide new therapies or diagnostic approaches for patients with AS and related conditions.
Why it matters
Potential benefit: If successful, findings could inform earlier diagnosis and new treatment targets to slow AS progression and reduce complications like heart failure and bleeding disorders.
How similar studies have gone: Prior work has linked TGF-beta signaling to valve disease progression in animal models, with ongoing exploration needed for human relevance.
Where this research is happening
-
Oklahoma Medical Research Foundation
Oklahoma City, United States Active
Researchers
- Principal investigator: Ahamed, Jasimuddin — Oklahoma Medical Research Foundation
- Study coordinator: Ahamed, Jasimuddin
Related research
Other NIH-funded projects on the same topics.
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Linking normal aortic valve blood flow patterns to risk of aortic valve narrowing
This grant studies how normal differences in how the aortic valve moves and carries blood might influence who develops aortic stenosis.
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Chronic Kidney Disease and Aortic Valve Disease: Understanding How Kidney Disease Influences Aortic Stenosis
This grant looks at how chronic kidney disease may affect the progression of aortic stenosis and whether we can find ways to slow it down for adults with kidney issues.
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Advanced non-invasive imaging to understand aortic stenosis biology
Aging adults with aortic stenosis may benefit from new imaging-based research to slow disease progression and reduce need for valve procedures.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.