Understanding how women's bodies respond to severe aortic stenosis to improve treatment outcomes

Who could benefit from this research

What this research studies

This research investigates the unique ways in which severe aortic stenosis affects women, who often face delayed diagnosis and treatment compared to men. By utilizing advanced medical imaging and computational modeling techniques, the study aims to uncover sex-specific differences in heart function and structure. The goal is to develop personalized treatment strategies that take into account these differences, ultimately enhancing the effectiveness of aortic valve replacement procedures for women. Patients may benefit from improved diagnostic tools and tailored treatment plans based on their individual anatomical and functional characteristics.

Why it matters

Where this research is happening

• Brigham and Women's Hospital
  Boston, United States Active

Researchers

• Principal investigator: Rikhtegar Nezami, Farhad — Brigham and Women's Hospital
• Study coordinator: Rikhtegar Nezami, Farhad

Related research

Other NIH-funded projects on the same topics.

• Aortic valve calcium and risk of severe aortic stenosis in people over 75

  This project looks at how common calcium on the aortic valve is in people over 75 and which factors make it more likely to progress to severe aortic narrowing.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11252602

• Predicting heart changes to improve care for women with severe aortic stenosis

  This project uses advanced medical imaging and computer models to better predict how women's hearts remodel from severe aortic stenosis so care can be more personalized.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11175320

• Investigating aortic valve calcium and its risks in older adults

  This study is looking at how common aortic valve calcification is in people aged 75 and older and how it might lead to serious heart problems, with the goal of finding ways to help those at higher risk.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11045115

• Investigating how stiffening of the aorta from elastin loss causes SVAS

  A new NIH grant is exploring why elastin loss leads to supravalvular aortic stenosis and how abnormal smooth muscle cell signaling causes the aorta to narrow in children.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11568641

• Risk prediction for aortic stenosis and how statins might help in adults 75 and older

  This grant seeks to identify which adults over 75 are at high risk for aortic valve disease and how statin therapy could influence that risk.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11429920

• AI-powered screening and monitoring for aortic stenosis in older adults

  A powerful new AI-based approach uses a simple heart rhythm test and a hand-held ultrasound to detect and monitor advanced aortic valve narrowing in people aged 65 and older.

  NIH research Yale University · New Haven, United States · NIH-11395442

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.