Understanding how women's bodies respond to severe aortic stenosis to improve treatment outcomes
Leveraging Sexual Dimorphism to Predict Cardiac Remodeling and Enhance Treatment in Women with Severe Aortic Stenosis
This study is looking at how severe aortic stenosis affects women differently than men, with the hope of creating better, personalized treatment plans for women to improve their heart valve replacement procedures.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10870456 on NIH RePORTER |
What this research studies
This research investigates the unique ways in which severe aortic stenosis affects women, who often face delayed diagnosis and treatment compared to men. By utilizing advanced medical imaging and computational modeling techniques, the study aims to uncover sex-specific differences in heart function and structure. The goal is to develop personalized treatment strategies that take into account these differences, ultimately enhancing the effectiveness of aortic valve replacement procedures for women. Patients may benefit from improved diagnostic tools and tailored treatment plans based on their individual anatomical and functional characteristics.
Who could benefit from this research
Good fit: Ideal candidates for this research are women diagnosed with severe aortic stenosis who may benefit from personalized treatment approaches.
Not a fit: Patients who are not women or those with mild aortic stenosis may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better treatment outcomes and survival rates for women suffering from severe aortic stenosis.
How similar studies have performed: Previous research has shown that sex-specific approaches in cardiovascular treatment can lead to improved outcomes, suggesting this study's approach is promising.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Rikhtegar Nezami, Farhad — Brigham and Women's Hospital
- Study coordinator: Rikhtegar Nezami, Farhad
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.