Condition

Valvular Heart Disease clinical trials and research

• 26Clinical trials
• 7NIH research projects
• 18Countries

Newest Valvular Heart Disease clinical trials

All recruiting trials (26)

• Hydra THV Transfemoral Valve Implantation in Severe Aortic Stenosis

  This registry tests how safely and effectively the Hydra THV works when implanted through the femoral artery in adults with severe symptomatic aortic stenosis.

  Recruiting at 8 sites Fundación EPIC · Aravaca and 7 other locations · NCT07566624

• Heart sound signals to detect valve and artery disease early

  This observational study tests whether a new digital stethoscope-like device can pick up heart sound patterns to detect valvular or coronary artery disease earlier in people who are already getting heart imaging.

  Recruiting Cambridge University Hospitals NHS Foundation Trust · Cambridge · NCT07496775

• Pulmonary Vascular Disease in Valvular Heart Disease: How Valve Procedures Affect Blood Flow

  This study tests how blood flow in the lungs changes in adults with left-sided valve disease who are having valve surgery and looks to see if patterns can predict reversibility of tricuspid regurgitation and right heart dysfunction.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07483203

• DELINEATE-Prospective: AI-assisted echocardiogram analysis for valve disease

  This project will test whether an AI system can automatically analyze echocardiograms to help doctors detect valve problems in adults who get heart ultrasounds.

  Recruiting Columbia University · New York, New York · NCT07197736

• MMVD: A Multicenter Registry to Understand Multiple and Mixed Valvular Heart Disease

  This study tests how common MMVD is, what imaging and management practices are used, and what factors influence outcomes in adults with two or more valve issues.

  Recruiting at 2 sites French Cardiology Society · Lille and 1 other locations · NCT07176507

• Aortic valve sizing: comparing CT scan measurements with measurements taken during surgery for people having surgical aortic valve replacement

  This will see if CT scan measurements match the aortic valve sizes surgeons measure during surgical aortic valve replacement in adults with severe aortic stenosis.

  Recruiting Maria Cecilia Hospital · Cotignola, Ravenna · NCT07125469

• Screening for valvular heart disease with a single-lead ECG

  This project will test whether a one-minute single-lead ECG can detect valve problems in adults by comparing ECG recordings to echocardiogram results.

  Recruiting I.M. Sechenov First Moscow State Medical University · Moscow · NCT07099417

• Longitudinal Assessment of Cardiac MRI Microstructure in Patients and Healthy People

  This study tests advanced, non-contrast and extended clinical cardiac MRI techniques to see how heart tissue features differ between people with heart disease and healthy individuals.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07081711

• How new metabolites affect valvular heart disease

  This project will test whether newly identified metabolites influence disease progression and outcomes in adults with valvular heart disease.

  Recruiting Sun Yat-sen University · Guangzhou, Guangdong · NCT07065500

• Optimized expansion of implanted transcatheter aortic valves to reduce leaflet thickening

  This trial will test whether using systematic extra balloon dilatation before and after TAVI reduces leaflet thickening on CT in people with severe symptomatic aortic stenosis who are not on long‑term blood thinners.

  Recruiting at 15 sites Copenhagen University Hospital, Rigshospitalet · Aalst and 16 other locations · NCT07042529

• Assessing arterial stiffness and heart disease risk using a novel technology

  This study is testing a new, no-touch technology to measure how stiff your arteries are and see if it can help figure out your risk for heart disease.

  Recruiting at 3 sites HJN Sverige AB/Neko Health · Stockholm and 2 other locations · NCT06984211

• Evaluating heart valve disease using cardiac CT scans

  This study is testing how advanced heart scans can help doctors better understand and manage heart valve disease in patients with moderate to severe conditions.

  Recruiting Toho University · Ōta-ku, Tokyo · NCT06937125

• AI-based assessment of heart function using ECG wearable monitors

  This study tests if a new AI tool using a wearable heart monitor can accurately check heart function in people with heart failure compared to traditional heart scans.

  Recruiting at 8 sites Peerbridge Health, Inc · Orange, California and 7 other locations · NCT06699056

• Comparing MitraClip and PASCAL for treating mitral regurgitation

  This study is testing two devices, MitraClip and PASCAL, to see which one works better for treating mitral regurgitation in patients who need this heart procedure.

  Recruiting LMU Klinikum · Munich, Bavaria · NCT06634121

• Registry for Abbott's heart devices

  This study is collecting information to see how safe and effective Abbott's heart devices are for patients getting them implanted in real-life hospital settings.

  Recruiting at 27 sites Abbott Medical Devices · Los Angeles, California and 35 other locations · NCT06590467

• Registry for transcatheter repair of tricuspid regurgitation

  This study is collecting information on how well transcatheter repairs or replacements for the tricuspid valve work for people with tricuspid regurgitation to help improve treatment choices for them.

  Recruiting LMU Klinikum · Munich, Bavaria · NCT06307262

• Home-based cardiac rehabilitation after heart valve procedures

  This study tests a home-based cardiac rehab program using a mobile app to see if it helps people who have had heart valve procedures improve their health without going to a rehab center.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT06077201

• Comparing body temperature management during heart surgery

  This study is testing whether managing body temperature differently during heart surgery can lead to better outcomes for patients.

  Recruiting at 8 sites University of Leicester · Leicester, Leicestershire and 10 other locations · NCT05996120

• Development of advanced MRI techniques for heart disease assessment

  This study is testing new MRI techniques to see how heart tissue differs between people with heart disease and healthy individuals to improve heart assessments.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT05654272

• New imaging protocol for heart conditions

  This study is testing a new imaging method for heart conditions to see if it can improve diagnosis and treatment for over 10,000 patients with heart issues.

  Recruiting Fatebenefratelli Hospital · Benevento · NCT05081115

• Simultaneous carotid artery stenting and cardiac surgery for high-risk patients

  This study tests if doing carotid artery stenting at the same time as heart surgery can help high-risk patients with both conditions recover better and have fewer complications.

  Recruiting John Paul II Hospital, Krakow · Krakow · NCT04973579

• Using PPG to Predict Heart Function in the General Population

  This study is testing if a wristband can help predict heart function in adults by comparing its readings with traditional heart scans.

  Recruiting at 3 sites Tulane University · New Orleans, Louisiana and 2 other locations · NCT04843371

• Follow-up on Abbott annuloplasty devices for heart valve repair

  This study is testing how safe and effective Abbott annuloplasty devices are for repairing heart valves in adults who are having heart surgery.

  Recruiting at 13 sites Abbott Medical Devices · Durham, North Carolina and 16 other locations · NCT04761120

• Using SMART watches to monitor patients after heart valve replacement

  This study tests if using a HUAWEI smartwatch to track heart rate, oxygen levels, and activity can help patients who have had heart valve replacement spot problems early and recover better.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT04454177

• Registry for patients with valvular heart disease undergoing interventions

  This study collects information from patients with serious heart valve problems who are getting a specific heart procedure to see how well it works and how they do over time.

  Recruiting Technical University of Munich · München · NCT03488732

• Registry of Valvular Heart Disease in Hospitalized Adults in China

  This study is trying to gather information about adults in China who are hospitalized with valvular heart disease to better understand how common it is, how it's treated, and what the outcomes are.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT03011697

NIH-funded research (7)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding how blood vessel cells change to help or worsen heart valves

  Researchers are studying how endothelial cells change and contribute to mitral valve prolapse to find better ways to treat this common heart valve condition.

  NIH research University of Rochester · Rochester, United States · NIH-11375710

• AI to find early mitral valve problems and predict future heart risks

  This project uses artificial intelligence on heart ultrasound images to find early mitral valve changes and predict which adults might later develop serious heart complications.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11325063

• Improving heart valve disease diagnosis with stress cardiac MRI

  This project aims to create a better way to understand mitral valve problems using a special heart MRI scan, helping doctors decide the best treatment for patients.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11138573

• Understanding the role of PKD3 in heart valve disease

  This study is looking into how certain heart cells change and affect heart valve health in people with valvular heart disease, with the hope of finding new ways to treat this condition and help patients feel better.

  NIH research University of Rochester · Rochester, United States · NIH-11135716

• Using AI to improve diagnosis and outcomes for mitral valve disease

  This study is looking at how we can use advanced computer technology to better understand mitral valve disease, helping doctors spot early signs of problems in heart images so they can provide better care and treatment for patients like you.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11064070

• Understanding Cilia's Role in Heart Valve Disease

  This project explores how tiny structures called cilia and certain gene changes might cause common heart valve problems like mitral valve prolapse.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11052516

• Improving heart valve disease assessment using advanced MRI techniques

  This study is testing a new type of heart scan to help doctors better understand and treat mitral valve regurgitation, so if you have this condition, it could lead to more accurate diagnoses and better treatment options for you.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-10877038

Related topics

Quick answers

How many Valvular Heart Disease clinical trials are recruiting right now?

26, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 18 countries. The most sites are in United States (9 trials), Germany (5 trials), Italy (4 trials), France (3 trials), China (3 trials). Each study page lists its sites and which ones are recruiting.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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