Condition

Transcatheter Aortic Valve Replacement clinical trials and research

• 14Clinical trials
• 8NIH research projects
• 1New in 30 days
• 13Countries

Newest Transcatheter Aortic Valve Replacement clinical trials

All recruiting trials (14)

• SYMmetric Valve expansion to reduce hypoattenuated leaflet thickening after balloon-expandable TAVI

  This trial tests whether the Double-TAP post-dilatation strategy can reduce HALT and improve valve function in patients 70 or older undergoing balloon-expandable TAVI.

  Recruiting Erasmus Medical Center · Düsseldorf and 4 other locations · NCT07872020

• Low-dose Colchicine after TAVR to help prevent valve clots

  This study tests whether taking a low dose of colchicine for 12 months after transcatheter aortic valve replacement can reduce valve thrombosis compared with standard care alone.

  Recruiting China National Center for Cardiovascular Diseases · Beijing · NCT07411768

• Transcatheter Mitral and Tricuspid Interventions and Cardiac MRI Registry

  This study will collect imaging and clinical data from adults undergoing transcatheter mitral or tricuspid procedures to see how their heart structure and function change over time using MRI and advanced ultrasound.

  Recruiting Centro Cardiologico Monzino · Milan, Milan · NCT07370467

• Evaluation of the Point-Guard device during heart valve replacement

  This study is testing a new device called Point-Guard to see if it can help prevent brain problems during heart valve replacement surgery.

  Recruiting Transverse Medical, Inc. · Clayton, Victoria · NCT06962371

• Single versus Dual Perclose Device Closure for Large-Bore Femoral Access in TAVR

  This will test whether using one Perclose device instead of two closes large-bore femoral access faster and with similar or fewer complications in people having transfemoral TAVR.

  Recruiting Wake Forest University Health Sciences · Milwaukee, Wisconsin · NCT06871774

• Assessing coronary artery disease in patients undergoing TAVI

  This study is testing whether a non-invasive way to check for heart artery problems is better than the usual invasive method for patients with severe aortic stenosis who are getting a new heart valve.

  Recruiting Insel Gruppe AG, University Hospital Bern · Bern · NCT06559332

• Comparing short and long aspirin therapy after heart valve replacement

  This study is testing if taking aspirin for just 3 months after heart valve replacement is as safe and effective as the usual 12 months for adults who have had the procedure.

  Recruiting Phase 3 University Hospital, Caen · Caen · NCT06518317

• Evaluating the SAPIEN 3 Ultra RESILIA Valve for Aortic Stenosis

  This study tests how well the new SAPIEN 3 Ultra RESILIA valve works for people with severe aortic stenosis who are getting a heart valve replacement, by checking its performance over the next 10 years.

  Recruiting Institut universitaire de cardiologie et de pneumologie de Québec, University Laval · Québec, Quebec · NCT06420830

• Assessing ischemic and bleeding risks after TAVR

  This study looks at the risks of bleeding and heart problems in patients getting a new heart valve through TAVR to see how to best tailor their blood-thinning treatment.

  Recruiting at 12 sites Niguarda Hospital · Aalst and 11 other locations · NCT06000943

• Evaluating coronary re-engagement after TAVR with a Navitor valve

  This study is testing if a new way of placing a heart valve during TAVR can help doctors still access the coronary arteries for patients who have both aortic stenosis and coronary artery disease.

  Recruiting Niguarda Hospital · Milan, Lombardy · NCT05779787

• Using low contrast CT for planning heart valve replacement

  This study is testing if using less contrast dye in special CT scans can help doctors plan heart valve replacement surgery while keeping patients safer and saving money.

  Recruiting Phase 4 University of Maryland, Baltimore · Baltimore, Maryland · NCT05758701

• Registry for patients undergoing Transcatheter Aortic Valve Replacement

  This study is tracking patients with severe aortic stenosis who are having a new heart valve procedure called TAVI to see how safe and effective it is for their health.

  Recruiting Federico II University · Naples · NCT05235555

• Using SMART watches to monitor patients after heart valve replacement

  This study tests if using a HUAWEI smartwatch to track heart rate, oxygen levels, and activity can help patients who have had heart valve replacement spot problems early and recover better.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT04454177

• Validation of a management algorithm for heart conduction issues after TAVR

  This study is testing a new plan to manage heart conduction problems that can happen after a TAVR procedure to see if it helps reduce the need for pacemakers and sudden deaths in patients.

  Recruiting Institut universitaire de cardiologie et de pneumologie de Québec, University Laval · Québec, Quebec · NCT04139616

NIH-funded research (8)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Rehabbing with Peloton: a heart-healthy fitness program on a popular app for people after TAVR

  A patient-friendly program uses a commercial fitness app to help people recovering from transcatheter aortic valve replacement improve daily activity and physical fitness.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11419593

• Home Peloton cardiac rehab for people recovering from TAVR

  This project offers an 8-week Peloton-based at-home exercise program to help people become more active and recover after transcatheter aortic valve replacement (TAVR).

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11328699

• How a patient's blood reacts during transcatheter aortic valve replacement (TAVR)

  This project looks at how individual patients' blood cells and blood flow change during TAVR to help reduce clotting and inflammation for people getting minimally invasive aortic valve replacements.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11251596

• Investigating how platelets and blood factors affect inflammation after heart valve replacement

  This study is looking at how blood platelets and other factors affect recovery after a heart procedure called TAVR, which helps people with a narrowed aortic valve, and it aims to find ways to make the procedure safer and more effective for patients who can't have regular surgery.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11136778

• How blood cell activity changes during aortic valve replacement

  This study is looking at how differences in your blood cells can impact your recovery after getting a new heart valve through a procedure called TAVR, with the hope of finding ways to make your experience better and reduce complications.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11002674

• Improving outcomes for patients undergoing aortic valve replacement

  This study looks at what helps some patients with aortic stenosis do better after getting a new heart valve through a procedure called TAVR, so we can find ways to improve care and reduce complications for everyone who has this treatment.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11001174

• Using Peloton for cardiac rehabilitation after heart valve surgery

  This study is looking at how using the Peloton fitness app can help people recovering from heart valve surgery get more active and stay healthy, making it easier for them to join in on their rehab from home.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-10985622

• Investigating how platelets and blood factors affect inflammation after heart valve replacement

  This study is looking at how certain blood factors affect recovery after a less invasive heart procedure called TAVR, which is used to treat severe aortic stenosis, to help doctors find better ways to prevent complications and improve patient outcomes.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-10864053

Related topics

Quick answers

How many Transcatheter Aortic Valve Replacement clinical trials are recruiting right now?

14, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in Italy (4 trials), China (2 trials), Canada (2 trials), United States (2 trials), Belgium (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →