Condition

Mitral Regurgitation clinical trials and research

• 43Clinical trials
• 9NIH research projects
• 27Countries

Newest Mitral Regurgitation clinical trials

All recruiting trials (43)

• Posterior Mitral Leaflet Replacement to Reduce Mitral Regurgitation

  This early feasibility trial tests the MR-ace Implant and Delivery System to see if it can reduce symptoms and leaks in people with moderate-to-severe functional mitral regurgitation.

  Recruiting Polares Medical SA · Atlanta, Georgia and 2 other locations · NCT07517588

• Replacing the native mitral valve with the ReValve System

  This study will test whether replacing the native mitral valve with the ReValve System helps adults with symptomatic, clinically significant mitral regurgitation who are appropriate candidates for mitral valve surgery.

  Recruiting at 3 sites Phase 1 ReValve Solutions Inc. · Tbilisi and 2 other locations · NCT07450911

• Mitral valve replacement with the SATURN TMVR system for severe mitral regurgitation

  This study tests whether the SATURN TS transcatheter mitral valve replacement can be safely implanted and work well in adults with severe mitral regurgitation who are high-risk for open-heart surgery.

  Recruiting at 2 sites InnovHeart · Los Angeles, California and 4 other locations · NCT07130994

• Outcomes after new edge-to-edge mitral valve repair

  This project will follow people with mitral regurgitation who receive transcatheter edge-to-edge repair at Amsterdam UMC to see how they do long-term and whether patient selection can be improved.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam, North Holland · NCT07108907

• Surgical implantation of a polymer prosthetic mitral or aortic valve

  This will test a surgically implanted polymer heart valve to see if it is safe and works well for adults who need mitral or aortic valve replacement.

  Recruiting Mitrassist Lifesciences Limited Co., Ltd. · Shanghai, Shanghai Municipality · NCT07097740

• GeminiOne transcatheter edge-to-edge repair for severe symptomatic mitral regurgitation

  This trial will try the GeminiOne TEER system to treat adults with severe, symptomatic mitral regurgitation who are high surgical risk or have not improved with medical therapy.

  Recruiting Sierra Valve LLC · Thousand Oaks, California · NCT07086534

• Comprehensive imaging of valve regurgitation and recurrence risk after atrial fibrillation ablation

  This project will use 3D transesophageal and transthoracic echocardiography to try to find imaging signs that predict valve regurgitation and which adults with atrial fibrillation planning ablation are more likely to have recurrence.

  Recruiting First Hospital of China Medical University · Shenyang, Liaoning · NCT07085650

• Abbott Cephea registry for mitral valve disease

  Collects clinical information on adults with symptomatic mitral valve disease to see how correcting the valve with the Cephea system affects outcomes for patients who might be candidates for transcatheter mitral valve replacement.

  Recruiting at 24 sites Abbott Medical Devices · Birmingham, Alabama and 23 other locations · NCT07069673

• Using a surgical assist system to help fix leaking mitral valves with a MitraClip-style procedure

  This trial will test whether adding a Structural Heart Surgery Assist System to transcatheter edge-to-edge repair (TEER) helps adults with moderate-to-severe or worse mitral regurgitation get equally safe and effective results compared with standard manual TEER.

  Recruiting Xiamen Cardiovascular Hospital, Xiamen University · Xiamen, Fujian · NCT07055919

• Antithrombotic approaches after transcatheter edge-to-edge repair for mitral regurgitation

  This test compares aspirin alone versus aspirin plus clopidogrel to see which is safer and more effective at preventing clots and bleeding after TEER in people with mitral regurgitation who do not need oral anticoagulants.

  Recruiting Phase 4 Chinese Academy of Medical Sciences, Fuwai Hospital · Beijing, Beijing Municipality · NCT07007143

• Antithrombotic approaches after transcatheter edge-to-edge mitral repair for patients who need oral anticoagulants

  This trial will test whether rivaroxaban alone or rivaroxaban plus clopidogrel better prevents clots and bleeding after TEER in people who need long-term oral anticoagulation.

  Recruiting Phase 4 Chinese Academy of Medical Sciences, Fuwai Hospital · Beijing, Beijing Municipality · NCT06901466

• Understanding Atrioventricular Regurgitation in ATTR Amyloid Cardiomyopathy

  This study is trying to understand how common certain heart valve problems are in people with ATTR amyloid cardiomyopathy and create better ways to measure their severity.

  Recruiting at 8 sites Medical University of Vienna · Graz, Styria and 7 other locations · NCT06836011

• Mitral valve annulus sizing with cardiac CT and 3D transesophageal echocardiography

  This project will test whether preoperative cardiac CT and intraoperative 3D transesophageal echocardiography can provide mitral annulus measurements that match the surgeon's ring sizing for adults with severe mitral regurgitation undergoing repair.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma · NCT06797687

• Identifying sex-specific biological markers in valvular heart disease

  This study is testing if special heart scans can help find different biological markers for men and women with aortic valve disease to improve treatment and recovery after surgery.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06780241

• Comparing two methods for repairing mitral regurgitation

  This study is testing whether using only ultrasound guidance for a heart repair procedure is as effective and safe as using both ultrasound and X-ray for older adults with mitral regurgitation.

  Recruiting Chinese Academy of Medical Sciences, Fuwai Hospital · Shenzhen, Guangdong · NCT06684171

• Comparing MitraClip and PASCAL for treating mitral regurgitation

  This study is testing two devices, MitraClip and PASCAL, to see which one works better for treating mitral regurgitation in patients who need this heart procedure.

  Recruiting LMU Klinikum · Munich, Bavaria · NCT06634121

• First use of Capstan Medical's device for mitral valve replacement

  This study is testing a new device for replacing the mitral valve in adults with serious heart valve problems who can't have traditional surgery to see how safe and effective it is.

  Recruiting at 2 sites Capstan Medical · Melbourne and 3 other locations · NCT06600191

• First use of the Sutra Hemi-valve for treating mitral regurgitation

  This study is testing a new heart valve replacement device to see if it can safely help people with severe mitral regurgitation who can't have traditional surgery.

  Recruiting Sutra Medical, Inc. · Hamilton · NCT06552689

• Left atrial shunt to help after mitral valve surgery

  This study tests whether making a small opening between the left and right atria during mitral valve repair can relieve high left atrial pressure for adults with primary mitral regurgitation.

  Recruiting Ottawa Heart Institute Research Corporation · Ottawa, Ontario · NCT06547788

• Evaluation of the AltaValve System for treating mitral regurgitation

  This study is testing a new device called the AltaValve System to see if it can help people with mitral regurgitation who can't have surgery feel better and improve their heart function.

  Recruiting at 58 sites 4C Medical Technologies, Inc. · Phoenix, Arizona and 57 other locations · NCT06465745

• Impact of mitral valve surgery on ventricular arrhythmias

  This study is testing how mitral valve surgery helps people with mitral valve prolapse and arrhythmias by looking at their heart health before and after the operation.

  Recruiting Karolinska Institutet · Stockholm, Stockholm County · NCT06255457

• Monitoring heart function with a wireless sensor for heart failure patients

  This study tests whether a wireless sensor can help doctors keep a closer eye on heart function in patients with heart failure and mitral regurgitation to improve their treatment and outcomes.

  Recruiting Columbia University · New York, New York · NCT06241430

• Transcatheter repair for severe mitral regurgitation in low to intermediate surgery risk patients

  This study is testing if a new heart valve repair method can safely help people with severe mitral regurgitation who are at low to intermediate risk for surgery.

  Recruiting Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong · NCT06162780

• Edge-to-edge mitral valve repair for ATTR-CM with mitral regurgitation

  This trial tests whether adding transcatheter edge-to-edge mitral valve repair helps patients with ATTR-associated cardiomyopathy and significant mitral regurgitation compared with standard medical therapy alone.

  Recruiting at 8 sites Medical University of Vienna · Graz and 9 other locations · NCT06075823

• Transseptal mitral valve replacement using the Tioga TMVR System

  The Tioga TMVR System will be tried in adults with symptomatic moderate-to-severe or severe mitral regurgitation who are not good candidates for surgery or other available treatments.

  Recruiting at 5 sites Tioga Cardiovascular, Inc. · São Paulo and 4 other locations · NCT06038838

• Evaluating a new device for treating severe mitral regurgitation

  This study is testing a new device to see if it can safely help people with severe mitral regurgitation feel better.

  Recruiting Peijia Medical Technology (Suzhou) Co., Ltd. · Suzhou, Jiangsu · NCT05655897

• Evaluating a new device for treating severe mitral regurgitation in patients in China

  This study is testing a new device to see if it can safely help adults with severe mitral regurgitation who are at high risk for surgery.

  Recruiting Peijia Medical Technology (Suzhou) Co., Ltd. · Suzhou, Jiangsu · NCT05610566

• Transcatheter Mitral Valve Replacement for Severe Mitral Regurgitation

  This study tests a new heart valve replacement method for people with severe mitral regurgitation who can't have other treatments to see if it helps them feel better.

  Recruiting at 38 sites Medtronic Cardiovascular · Aarhus and 37 other locations · NCT05496998

• Repairing the mitral valve in patients with cardiogenic shock

  This study tests if a new heart procedure called TEER can help patients in cardiogenic shock with leaky mitral valves feel better compared to standard treatments.

  Recruiting at 2 sites Ottawa Heart Institute Research Corporation · Rochester, Minnesota and 3 other locations · NCT05298124

• Evaluating a new mitral valve system for patients with severe mitral valve disease

  This study is testing a new mitral valve system to see if it can safely help patients with severe mitral valve disease who can't have traditional heart surgery.

  Recruiting at 20 sites Abbott Medical Devices · Phoenix, Arizona and 21 other locations · NCT05061004

• Transcatheter mitral valve repair for severe mitral regurgitation

  This study is testing a new device called Valveclip® to see if it can safely help people with moderate to severe mitral regurgitation feel better without needing traditional surgery.

  Recruiting Shanghai NewMed Medical Co., Ltd. · Sichuan · NCT05021614

• Registry for the Tendyne Mitral Valve System in patients with mitral regurgitation

  This study is testing the Tendyne Mitral Valve System to see if it is safe and effective for people with severe mitral regurgitation who can't have traditional surgery.

  Recruiting at 23 sites LMU Klinikum · Linz and 29 other locations · NCT04898335

• Feasibility of a new valve replacement for severe mitral regurgitation

  This study is testing a new valve replacement for people with severe mitral regurgitation who can't have traditional surgery to see if it is safe and effective for them.

  Recruiting at 13 sites HighLife SAS · Auchenflower and 13 other locations · NCT04888247

• Follow-up on Abbott annuloplasty devices for heart valve repair

  This study is testing how safe and effective Abbott annuloplasty devices are for repairing heart valves in adults who are having heart surgery.

  Recruiting at 13 sites Abbott Medical Devices · Durham, North Carolina and 16 other locations · NCT04761120

• Registry for optimal treatment options for mitral valve issues

  This study looks at how well different treatments work for people with serious mitral valve problems, comparing those who had a new valve implanted to those who weren't able to get that treatment.

  Recruiting at 43 sites Universitätsklinikum Hamburg-Eppendorf · Tucson, Arizona and 42 other locations · NCT04688190

• Using phenylephrine to assess mitral regurgitation severity

  This study is testing whether giving a medication called phenylephrine during heart scans can help doctors better understand how severe mitral regurgitation is in patients.

  Recruiting Phase 1/2 Montefiore Medical Center · New York, New York · NCT04500899

• MITRAL II Pivotal: Transcatheter mitral valve replacement for severe mitral annular calcification

  This trial tests whether placing an Edwards SAPIEN transcatheter valve through a transseptal approach helps high-surgical-risk adults with severe mitral annular calcification and symptomatic mitral valve dysfunction.

  Recruiting at 14 sites Mayo Clinic · Gilbert, Arizona and 16 other locations · NCT04408430

• Observational registry for patients treated with the NeoChord Artificial Chordae System

  This study is looking at how well the NeoChord Artificial Chordae System works for people with degenerative mitral valve disease over five years, without needing any extra procedures beyond regular treatment.

  Recruiting at 5 sites NeoChord · Bonn and 4 other locations · NCT04190602

• Evaluating a new transcatheter mitral valve for patients with severe mitral regurgitation

  This study is testing a new heart valve to see if it can safely help high-risk patients with severe mitral regurgitation who can’t have regular surgery.

  Recruiting at 39 sites HighLife SAS · Darlinghurst, New South Wales and 49 other locations · NCT04029363

• Transcatheter Mitral Valve Replacement for Severe Mitral Regurgitation

  This study is testing a new heart valve replacement method to see if it can help people with severe mitral regurgitation who are at high risk for surgery.

  Recruiting at 8 sites HighLife SAS · Tucson, Arizona and 9 other locations · NCT04029337

• Comparing early mitral valve repair to watchful waiting for asymptomatic patients with severe mitral regurgitation

  This study is testing whether early surgery to fix a leaky heart valve is better than just keeping an eye on it for people who don't have symptoms but have severe mitral regurgitation.

  Recruiting at 5 sites UMC Utrecht · Amsterdam and 5 other locations · NCT03975998

• Surgery for mild tricuspid regurgitation during mitral valve repair

  This study is testing if adding a specific heart surgery for mild tricuspid regurgitation can help patients who are already having mitral valve surgery to avoid future heart problems.

  Recruiting at 3 sites Ospedale San Raffaele · Rozzano, Milano and 2 other locations · NCT02996552

• Registry for patients undergoing MitraClip® procedure for mitral regurgitation

  This study collects information from patients with severe mitral regurgitation who are treated with the MitraClip® procedure to see how well it works and how safe it is for them.

  Recruiting Heinrich-Heine University, Duesseldorf · Düsseldorf · NCT02033811

NIH-funded research (9)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• EVOLVE-MR: Extending Valve-Surgery Outcomes to Real-World Patients with Mitral Regurgitation

  Aims to make the evidence from landmark valve surgery trials applicable to the everyday patients with mitral regurgitation by linking trial data with Medicare records to understand real-world outcomes.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11466111

• Decoupling heart valve fibrosis from ventricular remodeling in degenerative mitral regurgitation

  A medication-based approach aims to block a specific serotonin receptor to prevent harmful changes in the heart valve and surrounding tissue for people with degenerative mitral regurgitation.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-11401987

• Why the heart enlarges with mitral valve leakage (mitral regurgitation)

  This project looks at how leaking of the mitral valve causes heart muscle cells to stretch and the left ventricle to enlarge in adults with mitral regurgitation.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11321256

• Better defining non-ischemic cardiomyopathy with functional mitral regurgitation to predict treatment outcomes

  The team will use advanced heart MRI to better classify people with non-ischemic cardiomyopathy and functional mitral regurgitation so doctors can predict which treatments may work best.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11319841

• Comparing two treatments for severe mitral regurgitation

  This study is looking at how two different treatments for degenerative mitral regurgitation—one done through a small tube and the other through traditional surgery—affect patients' health and experiences, so we can better understand which option might work best for you over time.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11135718

• Understanding heart muscle changes due to mitral valve problems

  This study looks at how the heart changes when someone has mitral regurgitation, a common heart valve problem, and aims to understand why the heart can become enlarged and weak over time, which could help find better ways to treat patients with this condition.

  NIH research University of Utah · Salt Lake City, United States · NIH-11075371

• Improving treatment predictions for heart patients with mitral valve issues

  This study is looking at how to better understand and treat heart problems in people with non-ischemic cardiomyopathy and leaky heart valves, using advanced imaging techniques to help doctors choose the best treatments for each patient.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11073111

• Improving treatment for mitral regurgitation using personalized imaging techniques

  This study is working on a new way to use special imaging to better understand how your heart's mitral valve moves, which could help doctors choose the best treatment for your mitral regurgitation and improve your care.

  NIH research University of Texas at Austin · Austin, United States · NIH-10934339

• Measuring mitral valve leakage using advanced MRI and deep learning techniques

  This study is testing a new way to check how well your heart is working if you have mitral valvular regurgitation, using advanced MRI technology and smart computer tools to give a clearer picture of blood flow, so you can get better care and treatment for your heart.

  NIH research Northwestern University at Chicago · Chicago, United States · NIH-10907639

Related topics

Quick answers

How many Mitral Regurgitation clinical trials are recruiting right now?

43, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 27 countries. The most sites are in United States (14 trials), Germany (12 trials), China (10 trials), Italy (8 trials), France (7 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 2, Phase 1/2: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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