Investigating the link between chronic kidney disease and the progression of aortic stenosis.
Official title: Chronic Renal Insufficiency and Silent Progression of Aortic Stenosis (CRISP-AS)
Funded at Beth Israel Deaconess Medical Center · NIH-10844441 · Data updated 2026-11-12
This study is looking at how chronic kidney disease affects the worsening of a heart condition called aortic stenosis, and it's for people with kidney issues who want to understand their heart health better and find new ways to manage their condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $763,809 |
| NIH project number | 5R01HL169517-02 |
| Project ID | NIH-10844441 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older, particularly those with chronic kidney disease and aortic stenosis.
✕Less likely to help
Patients without chronic kidney disease or those who do not have aortic stenosis may not benefit from this research.
What this research studies
This research focuses on understanding how chronic kidney disease (CKD) affects the progression of aortic stenosis (AS), a serious heart condition. By analyzing data from large cohorts of patients with CKD, the study aims to identify risk factors that contribute to the worsening of AS. Participants will undergo detailed heart imaging and assessments to track changes over time, which could lead to new insights into managing AS in patients with kidney issues. The findings may help develop better treatment strategies for those at risk of severe AS.
Why it matters
Potential benefit: If successful, this research could lead to improved management and treatment options for patients with aortic stenosis, particularly those with chronic kidney disease.
How similar studies have gone: Previous research has shown promising results in understanding cardiovascular disease progression in patients with chronic kidney disease, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Strom, Jordan Blair — Beth Israel Deaconess Medical Center
- Study coordinator: Strom, Jordan Blair
Related research
Other NIH-funded projects on the same topics.
-
Chronic Kidney Disease and Aortic Valve Disease: Understanding How Kidney Disease Influences Aortic Stenosis
This grant looks at how chronic kidney disease may affect the progression of aortic stenosis and whether we can find ways to slow it down for adults with kidney issues.
-
Understanding Heart Valve Narrowing in People with Kidney Disease
This project aims to understand why a heart valve condition called aortic stenosis gets worse in people who also have kidney disease.
-
Investigating how stiffening of the aorta from elastin loss causes SVAS
A new NIH grant is exploring why elastin loss leads to supravalvular aortic stenosis and how abnormal smooth muscle cell signaling causes the aorta to narrow in children.
-
Risk prediction for aortic stenosis and how statins might help in adults 75 and older
This grant seeks to identify which adults over 75 are at high risk for aortic valve disease and how statin therapy could influence that risk.
-
AI-powered screening and monitoring for aortic stenosis in older adults
A powerful new AI-based approach uses a simple heart rhythm test and a hand-held ultrasound to detect and monitor advanced aortic valve narrowing in people aged 65 and older.
-
Chronic Renal Insufficiency Cohort: Phase 5 SDCC Support
This grant funds a central coordinating center to oversee a long-term study of adults with reduced kidney function and related health outcomes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.