Condition

Aortic Valve Stenosis clinical trials and research

• 72Clinical trials
• 3NIH research projects
• 1New in 30 days
• 36Countries

Newest Aortic Valve Stenosis clinical trials

All recruiting trials (72)

• Transcatheter Aortic Valve Replacement Registry for Outcomes and Quality Monitoring

  This registry collects information from hospitals about patients undergoing TAVR to see how care and outcomes compare to guidelines and nationwide data.

  Recruiting American College of Cardiology · Washington D.C., District of Columbia · NCT07908355

• Vericiguat to slow calcific aortic valve narrowing

  This trial tests whether vericiguat can slow the progression of mild-to-moderate calcific aortic valve stenosis compared with placebo.

  Recruiting Phase 2 West China Hospital · Chengdu, Sichuan · NCT07715279

• CHATEAU Registry: Real-world outcomes after TAVR

  This registry collects real-world data from adults who had TAVR between 2021 and 2025 to see how they do over time and how valve performance holds up.

  Recruiting Eunpyeong St. Mary's Hospital · Seoul · NCT07709858

• Impact of TAVR on kidney function in people with aortic valve disease

  This registry tests how trans-catheter aortic valve implantation affects kidney function and the risk of kidney injury in adults with aortic stenosis.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma, RM · NCT07626710

• Hydra THV Transfemoral Valve Implantation in Severe Aortic Stenosis

  This registry tests how safely and effectively the Hydra THV works when implanted through the femoral artery in adults with severe symptomatic aortic stenosis.

  Recruiting at 8 sites Fundación EPIC · Aravaca and 7 other locations · NCT07566624

• How the type of sedation affects recovery after TAVR

  This study will test whether three common sedation approaches (propofol, dexmedetomidine, or midazolam with fentanyl) change how people recover on the first day after transfemoral TAVR.

  Recruiting Phase 4 Endeavor Health · Glenview, Illinois · NCT07556523

• How TAVI and M‑TEER affect sleep‑disordered breathing

  This will see if adults with aortic stenosis or mitral regurgitation who undergo TAVI or M‑TEER have improvements in sleep‑disordered breathing six months after their procedure.

  Recruiting Hippocration General Hospital · Athens, Attica · NCT07520656

• Using 4D Flow MRI to characterize left ventricular failure

  This project will test whether automated 4D Flow MRI analysis can measure left ventricular dysfunction in adults with severe aortic stenosis who are scheduled for TAVR.

  Recruiting at 2 sites IRCCS Policlinico S. Donato · San Donato Milanese and 1 other locations · NCT07455292

• Antibiotic Prophylaxis for TAVI: Is Adding a beta-lactam effective?

  This trial tests whether adding a beta-lactam that covers Enterococcus faecalis to the usual cephalosporin prophylaxis during TAVI reduces bacterial infection or death within 6 months.

  Recruiting at 4 sites Copenhagen University Hospital, Rigshospitalet · Aalborg and 4 other locations · NCT07442357

• Intravenous iron infusion after transcatheter aortic valve implantation for people with iron deficiency

  This trial will test whether an intravenous iron infusion after TAVI helps people aged 65 and older with severe aortic stenosis and iron deficiency feel better and walk farther.

  Recruiting Phase 4 Erasmus Medical Center · Rotterdam, South Holland · NCT07370688

• Smartphone-based screening for aortic valve stenosis

  A smartphone-based screening approach is being tested to see if it can help identify aortic valve stenosis in adults, using signals captured by the device.

  Recruiting Medical University Innsbruck · Innsbruck · NCT07284550

• EmStop Embolic Protection System for TAVR in Aortic Valve Stenosis

  This study tests whether the EmStop protective device can safely capture and remove debris during transcatheter aortic valve replacement in adults with severe aortic valve stenosis.

  Recruiting at 7 sites EmStop Inc · Thousand Oaks, California and 6 other locations · NCT07276711

• Tracking progression and consequences of heart valve disease

  This project will follow adults with moderate or worse valve disease to see if clinical tests and imaging can predict when their condition will get worse.

  Recruiting at 15 sites Second Affiliated Hospital, Zhejiang University, School of Medicine · Fuzhou, Fujian and 14 other locations · NCT07267117

• TAVI-in-TAVI with Myval: following patients who had a prior TAVI to see how they do over time

  This study follows about 300 adults who are undergoing or have had a TAVI-in-TAVI procedure with the Myval valve to see how they fare over up to five years.

  Recruiting IHF GmbH - Institut für Herzinfarktforschung · Freiburg im Breisgau · NCT07215143

• Measuring arterial blood volume changes and heart pumping efficiency

  This pilot will test whether the HemoCept device can detect changes in arterial blood volume and heart pumping efficiency in adults with aortic valve stenosis who are being treated at the participating center.

  Recruiting HemoCept Inc. · Boulder, Colorado · NCT07205341

• Using a steerable VitaFlow Liberty Flex catheter to deliver transcatheter aortic valves in patients with difficult aortic anatomy

  This study will test whether the steerable VitaFlow Liberty Flex delivery system helps doctors place transcatheter aortic valves more safely in people with severe aortic stenosis and challenging aortic-left ventricular angles (>60°).

  Recruiting Shanghai Zhongshan Hospital · Shanghai, Shanghai Municipality · NCT07145463

• Korea VHD Echo Study: Real-World Practice of Aortic, Mitral, and Tricuspid Valves

  This study looks at how valvular heart disease is managed in Korea by reviewing echocardiograms and medical records from multiple centers to see patterns in disease progression and treatment.

  Recruiting at 2 sites Yonsei University · Seoul, Seoul and 1 other locations · NCT07068633

• Ultra-high-resolution cardiac CT with NAEOTOM Alpha before TAVI

  This study will test whether ultra-high-resolution photon-counting CT can accurately detect coronary artery disease in patients having TAVI and potentially reduce the need for invasive coronary angiography.

  Recruiting at 3 sites Semmelweis University · Charleston, South Carolina and 6 other locations · NCT07016477

• CardioHeartConnect: Home Peloton cardiac rehab after TAVR

  This trial tests whether an eight-week home-based Peloton program paired with a smartwatch helps people recovering from TAVR become more active and improve heart-related health compared with educational materials.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT07008911

• Evaluation of the Point-Guard device during heart valve replacement

  This study is testing a new device called Point-Guard to see if it can help prevent brain problems during heart valve replacement surgery.

  Recruiting Transverse Medical, Inc. · Clayton, Victoria · NCT06962371

• Registry of patients undergoing transcatheter aortic valve implantation in Kazakhstan

  This study looks at patients in Kazakhstan who have had aortic valve surgery to see how well they do and how their quality of life changes over time.

  Recruiting National Research Center for Cardiac Surgery, Kazakhstan · Astana · NCT06874465

• Portuguese Myval transcatheter aortic valve registry

  This project will try the Myval transcatheter heart valve in adults with symptomatic severe aortic stenosis who are having a TAVI procedure to see how safe and effective it is.

  Recruiting at 4 sites Portuguese Association of Interventional Cardiology · Carnaxide and 5 other locations · NCT06818435

• Comparing Transcatheter and Surgical Aortic Valve Replacement for Bicuspid Aortic Valve Patients

  This study is testing whether a new heart valve replacement method works better than the traditional surgery for people with severe aortic stenosis and a bicuspid aortic valve.

  Recruiting Cedars-Sinai Medical Center · Los Angeles, California · NCT06817148

• Registry to evaluate the Myval Transcatheter Heart Valve System

  This study is testing how well the Myval heart valve works for people with aortic valve stenosis in real-life settings across different hospitals in Germany.

  Recruiting University of Luebeck · Lübeck, Schleswig-Holstein · NCT06804148

• Comparing two pain management techniques for patients undergoing heart valve replacement

  This study is testing two different pain relief methods for patients having heart valve replacement surgery to see which one helps them feel better after the procedure.

  Recruiting Medipol University · Istanbul · NCT06773780

• Remote monitoring for patients after heart valve replacement

  This study tests if using remote monitoring can help patients who have had heart valve replacement recover better and go home sooner by catching any problems early.

  Recruiting Imperial College London · London · NCT06602609

• Imaging data collection for patients undergoing Transcatheter Aortic Valve Implantation

  This study is collecting imaging data from patients with severe aortic stenosis who are getting a new heart valve to see if these scans can help predict how well the valve will work in the future.

  Recruiting Barts & The London NHS Trust · London, England · NCT06596460

• Treatment for gum disease to slow heart valve narrowing

  This study is testing if treating gum disease can help slow down the worsening of heart valve narrowing in adults who have both aortic valve stenosis and gum issues.

  Recruiting China National Center for Cardiovascular Diseases · Beijing, Beijing Municipality · NCT06587971

• VitaFlow LIBERTY Europe: real-world use of a transcatheter aortic valve

  This project will test the safety and performance of the VitaFlow Liberty transcatheter aortic valve in adults with severe, symptomatic aortic stenosis who are at high risk for open-heart surgery.

  Recruiting at 9 sites Shanghai MicroPort CardioFlow Medtech Co., Ltd. · Galway and 8 other locations · NCT06535659

• Evaluating the Hydra heart valve for aortic valve stenosis

  This study is testing how well the Hydra heart valve works and is safe for people with severe aortic stenosis after they have the valve implanted.

  Recruiting at 2 sites Sahajanand Medical Technologies Limited · Sheffield, Yorkshire and 3 other locations · NCT06507579

• Using Myval heart valves for aortic valve replacement through the armpit

  This study is testing if using the Myval heart valve for aortic valve replacement through the armpit is safe and effective for people with aortic valve stenosis.

  Recruiting University of Luebeck · Lübeck, Schleswig-Holstein · NCT06493994

• Evaluating the SAPIEN 3 Ultra RESILIA Valve for Aortic Stenosis

  This study tests how well the new SAPIEN 3 Ultra RESILIA valve works for people with severe aortic stenosis who are getting a heart valve replacement, by checking its performance over the next 10 years.

  Recruiting Institut universitaire de cardiologie et de pneumologie de Québec, University Laval · Québec, Quebec · NCT06420830

• Evaluating the Hydra valve for severe aortic stenosis in Copenhagen

  This study is testing a new type of heart valve for people with severe aortic stenosis to see how well it works and if it causes any new heart rhythm problems after the procedure.

  Recruiting Sahajanand Medical Technologies Limited · Copenhagen · NCT06342635

• Investigating multiple and mixed heart valve diseases

  This study looks at how common different types of heart valve diseases are and their features by gathering information from patients around the world who have been diagnosed with these conditions.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris, Île-de-France Region · NCT06235385

• Reversing heparin with protamine after transfemoral TAVI

  This trial tries giving protamine to reverse heparin right after transfemoral TAVI in adults to see if it reduces bleeding and vascular complications.

  Recruiting Phase 3 Assistance Publique - Hôpitaux de Paris · Paris, Île-de-France Region · NCT06215378

• Comparing two types of transcatheter aortic valves for patients with valve deterioration

  This study is testing which of two types of heart valves works better for patients who need a replacement due to valve problems.

  Recruiting at 12 sites Fundación EPIC · Alessandria and 11 other locations · NCT06049654

• Assessing ischemic and bleeding risks after TAVR

  This study looks at the risks of bleeding and heart problems in patients getting a new heart valve through TAVR to see how to best tailor their blood-thinning treatment.

  Recruiting at 12 sites Niguarda Hospital · Aalst and 11 other locations · NCT06000943

• Biobank for studying genetic factors in aortic stenosis and cardiovascular diseases

  This study is collecting samples and health information from people with aortic stenosis and other heart diseases to see if they can find new genetic clues that could improve diagnosis and treatment.

  Recruiting at 2 sites McGill University Health Centre/Research Institute of the McGill University Health Centre · Montreal, Quebec and 1 other locations · NCT05930899

• Evaluating the GEMINUS TAVI System for Aortic Stenosis

  This study is testing a new heart valve system to see if it is safe and works well for people with severe aortic stenosis.

  Recruiting Valve Medical · Petah Tikva and 1 other locations · NCT05909748

• Evaluation of a new transcatheter valve for severe aortic stenosis

  This study is testing a new heart valve procedure for people with severe aortic stenosis who can't have regular surgery to see if it can safely improve their health.

  Recruiting Shanghai NewMed Medical Co., Ltd. · Shanghai · NCT05864456

• Evaluating coronary re-engagement after TAVR with a Navitor valve

  This study is testing if a new way of placing a heart valve during TAVR can help doctors still access the coronary arteries for patients who have both aortic stenosis and coronary artery disease.

  Recruiting Niguarda Hospital · Milan, Lombardy · NCT05779787

• Evaluating treatments for severe aortic valve stenosis in elderly patients in Italy

  This study is trying to see which treatments work best for elderly patients with severe aortic valve stenosis who need valve replacement, to improve their quality of life.

  Recruiting IRCCS Policlinico S. Donato · San Donato Milanese, MI · NCT05778773

• Assessing the impact of leaflet thrombosis on aortic valve degeneration after TAVI

  This study is trying to see how leaflet thrombosis affects the long-term health of aortic valves in patients who have had a transcatheter aortic valve replacement.

  Recruiting at 3 sites St. Antonius Hospital · Copenhagen and 3 other locations · NCT05758662

• Effects of beta blockers on patients undergoing TAVI for aortic valve stenosis

  This study is testing whether stopping or continuing beta-blocker medication helps adults undergoing heart valve surgery feel better and have fewer complications afterward.

  Recruiting at 2 sites Phase 4 National and Kapodistrian University of Athens · Nicosia and 1 other locations · NCT05721170

• Improving decision-making for patients with aortic valve stenosis

  This study tests if a new way of helping patients with severe aortic stenosis make treatment choices can improve their satisfaction and outcomes compared to standard care.

  Recruiting at 2 sites Insel Gruppe AG, University Hospital Bern · Bern and 1 other locations · NCT05711186

• Using Enavogliflozin to Improve Outcomes After Aortic Valve Replacement

  This study is testing if a new heart medication called Enavogliflozin can help people who have had aortic valve replacement surgery avoid serious heart problems and improve their health.

  Recruiting at 28 sites Phase 4 Asan Medical Center · Bucheon-si and 30 other locations · NCT05672836

• Using MRI to assess heart valve replacement in patients with aortic stenosis

  This study is testing if MRI can show how well different types of heart valves work during exercise in younger patients with aortic stenosis to help improve their recovery and quality of life after valve replacement.

  Recruiting University Hospitals Cleveland Medical Center · Cleveland, Ohio · NCT05603026

• Comparing minimal invasive extracorporeal circulation to conventional cardiopulmonary bypass in heart surgery

  This study is testing if a new heart surgery method called minimal invasive extracorporeal circulation can help patients avoid serious complications better than the traditional method.

  Recruiting at 5 sites Aristotle University Of Thessaloniki · Toronto and 12 other locations · NCT05487612

• Optimizing heart valve function using echocardiography or catheterization after valve replacement

  This study is testing whether using ultrasound or a catheter to check heart valve function after a replacement helps patients with aortic valve problems feel better and have better outcomes.

  Recruiting at 5 sites Institut universitaire de cardiologie et de pneumologie de Québec, University Laval · San Francisco, California and 6 other locations · NCT05459233

• Evaluating fetal aortic valve balloon dilation for congenital heart defects

  This study is testing whether a procedure called fetal aortic valvuloplasty can help fetuses with aortic valve problems caused by hypoplastic left heart syndrome feel better and have better outcomes.

  Recruiting at 13 sites Queen Silvia Children's Hospital, Gothenburg, Sweden · San Francisco, California and 12 other locations · NCT05386173

• Impact of Local Tissue Inflammation on Heart Conduction After Valve Implantation

  This study tests whether local tissue inflammation affects heart conduction pathways after percutaneous aortic valve replacement in adults with aortic stenosis.

  Recruiting Phase 2 University Hospital, Brest · Brest · NCT05308888

• Using Ticagrelor or Aspirin for Patients After Aortic Valve Implantation

  This study tests whether Ticagrelor works better than Aspirin to prevent blood clots and complications in adults with severe aortic stenosis after they have a heart valve replacement.

  Recruiting Phase 4 Fundacin Biomedica Galicia Sur · Vigo, Pontevedra · NCT05283356

• Evaluating the SAPIEN X4 Heart Valve for Patients with Failing Aortic Bioprosthetic Valves

  This study is testing a new heart valve to see if it can help people with failing aortic bioprosthetic valves feel better and stay healthy.

  Recruiting at 30 sites Edwards Lifesciences · Newport Beach, California and 36 other locations · NCT05172973

• Registry of patients treated with transcatheter aortic valve implantation in Leipzig

  This study collects information from patients who have received a new heart valve through a minimally invasive procedure in Leipzig to see how well the treatment works over time.

  Recruiting Helios Health Institute GmbH · Leipzig · NCT05015452

• Using angiotensin receptor blockers to treat aortic stenosis

  This study is testing if a common heart medication can help people with mild-to-moderate aortic stenosis by slowing its progression and improving heart function.

  Recruiting at 2 sites Phase 4 Institut universitaire de cardiologie et de pneumologie de Québec, University Laval · Québec, Quebec and 1 other locations · NCT04913870

• Evaluating a new valve system for severe aortic stenosis

  This study is testing a new valve system to see if it can safely help people with severe aortic stenosis who can't have traditional surgery.

  Recruiting Chengdu Silara Meditech Inc. · Beijing · NCT04893603

• Managing moderate aortic stenosis with TAVR or clinical surveillance

  This study is testing whether a new heart valve replacement method called TAVR is safer and more effective than just monitoring people with moderate aortic stenosis.

  Recruiting at 50 sites Edwards Lifesciences · Huntsville, Alabama and 79 other locations · NCT04889872

• Examining heart blood flow in patients with severe aortic valve narrowing

  This study tests how two heart flow measurements can help doctors understand and treat patients with severe aortic valve narrowing and coronary artery disease.

  Recruiting Heart and Diabetes Center North-Rhine Westfalia · Bad Oeynhausen, North Rhine-Westphalia · NCT04882488

• Observational study of Myval™ heart valves in patients with severe aortic valve stenosis

  This study looks at how well the Myval™ heart valves work and their safety for people with severe aortic valve stenosis by checking the health outcomes of patients who received them.

  Recruiting at 8 sites Meril Life Sciences Pvt. Ltd. · Tallinn and 7 other locations · NCT04703699

• A quick 10-minute heart scan for cardiac diseases

  This study is testing a quick 10-minute heart scan to see if it can help diagnose heart problems better and faster for many patients without needing special dyes.

  Recruiting McGill University Health Centre/Research Institute of the McGill University Health Centre · Montreal, Quebec · NCT04464655

• Evaluating the VitaFlow™ Transcatheter Aortic Valve System for severe aortic stenosis

  This study is testing a new heart valve system to see if it safely helps people with severe aortic stenosis who can't have traditional surgery.

  Recruiting Shanghai MicroPort CardioFlow Medtech Co., Ltd. · Shanghai, Shanghai Municipality and 1 other locations · NCT04414865

• Comparing Myval THV with Contemporary Valves for Aortic Valve Stenosis

  This study is testing if a new heart valve called Myval works better and is safer than current heart valves for people with severe aortic valve narrowing.

  Recruiting at 36 sites Meril Life Sciences Pvt. Ltd. · Minsk and 53 other locations · NCT04275726

• Identifying the best treatment for aortic valve disease

  This study is trying to find the best treatment for people with severe aortic valve disease by looking at their individual health factors and how different treatments work for them.

  Recruiting Universitätsklinikum Hamburg-Eppendorf · Hamburg · NCT04227002

• Early Aortic Valve Replacement for Patients With Asymptomatic Severe Aortic Stenosis

  This study is testing if early aortic valve replacement can help people with severe aortic stenosis who don’t have symptoms but show early signs of heart problems, compared to just waiting for symptoms to appear.

  Recruiting Odense University Hospital · Odense, Fyn · NCT03972644

• Improving TAVI outcomes with point-of-care testing for Von Willebrand Factor

  This study is testing whether quick testing for Von Willebrand Factor during TAVI procedures can help improve outcomes and reduce complications for patients with aortic stenosis.

  Recruiting at 4 sites University Hospital, Lille · Clermont-Ferrand and 8 other locations · NCT03728049

• Scanning the heart for a key enzyme (HDAC) using 11C‑Martinostat PET‑MR

  This trial will test whether a PET‑MR scan with the tracer 11C‑Martinostat can detect HDAC enzyme activity in people with aortic stenosis, people with diabetes, and healthy volunteers.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT03549559

• Personalized activity intervention for patients recovering from heart surgery

  This study is testing whether a personalized activity program can help patients recovering from heart surgery feel better and recover faster compared to standard rehabilitation.

  Recruiting Kuopio University Hospital · Kuopio · NCT03470246

• Comparing monitoring strategies for patients with new left bundle branch block after heart valve surgery

  This study is testing if a new monitoring method can help people who develop a heart condition after valve surgery feel better and avoid serious problems like fainting or hospitalization.

  Recruiting at 8 sites Montreal Heart Institute · Edmonton, Alberta and 9 other locations · NCT03303612

• Registry of patients treated with transcatheter aortic valve implantation

  This study is tracking the health and recovery of patients who receive a new heart valve through a minimally invasive procedure to see how well it works over time.

  Recruiting Segeberger Kliniken GmbH · Bad Segeberg · NCT03192774

• Registry for Aortic Valve Replacement Treatments in Europe

  This study is collecting data from patients in Europe to see how well different surgical treatments for severe aortic valve stenosis work and how they affect quality of life.

  Recruiting University of Parma · Verona · NCT03143361

• Comparing imaging methods before heart valve replacement

  This study is testing different imaging methods to see which one works best for measuring the aortic root in patients with aortic valve stenosis before they get a heart valve replacement.

  Recruiting Heinrich-Heine University, Duesseldorf · Düsseldorf, North Rhine-Westphalia · NCT01805739

• Registry for tracking outcomes of transcatheter aortic valve replacement

  This study is tracking how well transcatheter aortic valve replacement works for people with severe heart valve problems to help improve patient care and outcomes.

  Recruiting The Society of Thoracic Surgeons · Washington D.C., District of Columbia · NCT01737528

NIH-funded research (3)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Metformin Readiness for Aortic Valve Stenosis

  A plan to prepare for a patient-focused trial of metformin to slow aortic valve stenosis in adults, using insights from human valves and biology.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11441442

• Understanding how immune cells affect aortic valve disease differently in men and women

  This study is looking at how men and women experience heart valve problems caused by aortic valve stenosis, focusing on the role of immune cells and inflammation, to find new treatments that could work better for each sex.

  NIH research University of Colorado · Boulder, UNITED STATES · NIH-10998691

• Understanding how genetic factors influence aortic valve disease progression

  This study is looking at the genes and molecules involved in calcific aortic valve disease (CAVD) to find new ways to treat it, which could help patients who currently have few options and often need surgery.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-10947414

Related topics

Quick answers

How many Aortic Valve Stenosis clinical trials are recruiting right now?

72, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 36 countries. The most sites are in United States (14 trials), Germany (12 trials), Italy (11 trials), Canada (10 trials), Spain (8 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 6, Phase 2: 2, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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