Using advanced MRI to assess severe low-gradient aortic stenosis
Official title: 4D Flow MRI in Assessment of True Severe Low-Gradient Aortic Stenosis
Funded at University of Louisville · NIH-10912050 · Data updated 2026-11-12
This study is looking at a special type of MRI to help doctors better understand and diagnose patients with low-gradient aortic stenosis, especially when their heart tests and symptoms don’t seem to match, so they can provide more personalized treatment options.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Louisville NIH-funded |
| Lab location | 1 site (Louisville, United States) |
| Project start | September 1, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $195,625 |
| NIH project number | 5R21AG080859-02 |
| Project ID | NIH-10912050 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with low-gradient aortic stenosis who exhibit discordant echocardiographic findings.
✕Less likely to help
Patients with non-aortic stenosis related heart conditions or those who do not have low-gradient aortic stenosis may not benefit from this research.
What this research studies
This research investigates the use of 4D flow MRI to better understand and assess patients with low-gradient aortic stenosis, a condition where the severity of heart valve narrowing is difficult to determine. The study aims to clarify the true severity of aortic stenosis in patients who show discordant results between echocardiography and clinical symptoms. By employing advanced imaging techniques, the researchers hope to improve diagnostic accuracy and patient management. This approach could lead to more tailored treatment options for affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment strategies for patients with low-gradient aortic stenosis, potentially reducing the risk of serious complications.
How similar studies have gone: Previous research has shown promise in using advanced imaging techniques for assessing heart conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Louisville
Louisville, United States Active
Researchers
- Principal investigator: Amini, Amir a — University of Louisville
- Study coordinator: Amini, Amir a
Related research
Other NIH-funded projects on the same topics.
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This grant looks at how chronic kidney disease may affect the progression of aortic stenosis and whether we can find ways to slow it down for adults with kidney issues.
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Aging adults with aortic stenosis may benefit from new imaging-based research to slow disease progression and reduce need for valve procedures.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.