Using angiotensin receptor blockers to treat aortic stenosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of angiotensin receptor blockers (ARBs) on patients with mild-to-moderate aortic stenosis. It is a randomized control trial designed to determine whether ARBs can slow the progression of aortic stenosis and reduce left ventricular remodeling and dysfunction. The study is based on previous findings that suggest the renin-angiotensin system may contribute to the worsening of aortic stenosis and myocardial fibrosis. Participants will be assigned to receive either ARBs or a placebo.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Mild to moderate aortic stenosis (peak aortic jet velocity ≥2.5 and \<4m/s)
* Normal left ventricular ejection fraction (i.e. ≥50%)
* Systolic blood pressure \>110 mmHg
* Diastolic blood pressure \>70 mmHg

Exclusion Criteria:

* More than mild aortic or mitral regurgitation, or mitral stenosis
* Current use or documented indication for renin-angiotensin system medication or Aliskiren
* Known allergy or intolerance to angiotensin II receptor blockers (ARBs)
* Alzheimer, dementia or known non-compliant patient
* Renal dysfunction (glomerular filtration rate \<30ml/min/1.73m2)
* Chronic hyperkalemia
* Diagnosed hepatic failure, cirrhosis, hepatitis or history of hepatic impairment
* Newly diagnosed (\<2 months) or poorly controlled diabetes
* Pre-existing obstructive coronary artery disease with CCS III-IV angina or recent myocardial infarction (\<3 months)
* Pregnant or lactating women
* Patients unable to read, understand or sign research consent

Where it's running

• Criucpq
  Québec, Quebec, Canada Recruiting
• Odense University Hospital
  Odense, Denmark Recruiting

Study contacts

• Principal investigator: Marie-Annick Clavel, PhD — Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
• Study coordinator: Marie-Annick Clavel, PhD
• Email: Marie-Annick.Clavel@criucpq.ulaval.ca
• Phone: 418-656-8711

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Vericiguat to slow calcific aortic valve narrowing

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.