Assessing changes in aortic diameter after valve replacement

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study evaluates the changes in ascending aortic diameter in patients undergoing transcatheter aortic valve replacement (TAVR). It aims to determine whether the diameter increases or remains stable post-procedure, particularly in patients with pre-existing aortic dilatation. Additionally, the study seeks to identify factors that contribute to postoperative aortic dilatation. By refining risk stratification for TAVR candidates, this research could enhance patient outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Severe aortic stenosis defined as an aortic valve area of 1cm2 or less or an indexed aortic valve area of 0.6cm2/m2 or less;
* Presence of clinical symptoms defined as a New York Heart Association functional class of 2 or more;
* High risk of surgical aortic valve replacement;
* Suitability for a transfemoral vascular access.

Exclusion Criteria:

* Dominant aortic regurgitation;
* History of surgical or transcatheter aortic valve replacement;
* History of aortic surgery;
* Connective tissue disorders.

Where it's running

• National Center for Cardiovascular Disease, China & Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Xiangbin Pan, Dr
• Email: panxiangbin@fuwaihospital.org
• Phone: 0086-010-88396666

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Comparing self-expandable and balloon-expandable valves for aortic dilation treatment

  This study is testing whether self-expandable or balloon-expandable valves work better for people with aortic dilation who are getting a heart valve replacement.

  Recruiting China National Center for Cardiovascular Diseases · Beijing, Beijing Municipality and 2 other locations · NCT06743568

• Exercise and nutrition support before and after TAVI for older adults with aortic stenosis

  This trial tests whether a personalized exercise program plus protein and iron supplements before and after a transcatheter valve replacement can help older adults with aortic stenosis recover better than standard care.

  Recruiting University Hospital of Ferrara · Ferrara, FE · NCT07895719

• Association Between Aortic Valve Area Changes and Pulmonary Congestion After TAVI

  This study tests whether improvements in aortic valve opening after TAVI relate to reductions in lung congestion measured by ultrasound in adults with severe aortic stenosis.

  Recruiting Istanbul University - Cerrahpasa · Istanbul, Istanbul · NCT07794436

• Systematic 14-day ambulatory heart monitoring after TAVI

  After TAVI, patients with certain heart conduction abnormalities will try 14 days of wearable ECG monitoring to see if it lowers the chances of sudden death, symptomatic heart rhythm problems, or stroke within a year compared to standard follow-up.

  Recruiting Institut universitaire de cardiologie et de pneumologie de Québec, University Laval · Québec, Quebec · NCT07739316

• Echo-AVCS: Drawing AI-powered clues from heart scans to confirm severe aortic stenosis

  This study tests an AI-based echocardiography score to help confirm severe aortic stenosis in adults who are also getting CT calcium scoring.

  Recruiting at 4 sites Azienda Ospedaliera "Sant'Andrea" · Bologna and 4 other locations · NCT07620925

• TAVI without on-site heart surgery: can selected centers do it safely?

  This trial tests whether transcatheter aortic valve implantation can be done safely in certain hospitals that don’t have on-site cardiac surgery, for patients with severe aortic stenosis who are appropriately selected.

  Recruiting at 10 sites University Hospital of Ferrara · Andria and 10 other locations · NCT07604402

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.