Understanding Aortic Stenosis Progression and Treatment Outcomes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the causes and progression of aortic stenosis, particularly following aortic valve replacement. Participants will undergo regular echocardiography every six months and annual advanced imaging techniques, such as PET-CT and MRI, to assess disease processes like fibrosis and inflammation. The study will utilize both existing and newly recruited cohorts to compare various stages of aortic stenosis severity over a four-year period. Clinical assessments and blood sampling will also be conducted to gather comprehensive data.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male or female aged \>50 years
* Provision of informed consent prior to any study specific procedures
* Patients with bioprosthetic aortic valve replacements, including both surgically and transcatheter implanted valves
* Patients with severe aortic stenosis (peak velocity \>4.0 m/s; previously recruited patients)
* Patients with moderate aortic stenosis (peak velocity 3.0-4.0 m/s; new prospectively recruited patients)
* Patients with mild aortic stenosis (peak velocity 2.5-2.9 m/s; new prospectively recruited patients)
* Patients with aortic sclerosis (tri-leaflet thickened aortic valve with no obstruction of ventricular outflow)
* Age and sex-matched healthy volunteers

Exclusion Criteria:

* Inability or unwilling to give informed consent.
* Those with an allergy to iodinated contrast
* Patients with impaired renal function (eGFR of \<30 mL/min/1.73m2)
* Women who are pregnant or breastfeeding.
* Patients with known Rheumatic Heart Disease
* Patients with known Ochronosis
* Patients with known Familial Homozygous Hypercholesterolaemia

Where it's running

• University of Edinburgh
  Edinburgh, United Kingdom Recruiting

Study contacts

• Study coordinator: Neil Craig
• Email: neil.craig@ed.ac.uk
• Phone: 07383558066

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Echo-AVCS: Drawing AI-powered clues from heart scans to confirm severe aortic stenosis

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  Recruiting at 4 sites Azienda Ospedaliera "Sant'Andrea" · Bologna and 4 other locations · NCT07620925

• TAVI without on-site heart surgery: can selected centers do it safely?

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• Willem AI for early detection of aortic stenosis from a 12‑lead ECG

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  Recruiting at 2 sites Idoven 1903 S.L. · Bonn and 1 other locations · NCT07479992

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.