Investigating the causes of aortic stenosis using advanced imaging techniques
Official title: Advanced Non-invasive Imaging in the Investigation of Aortic Stenosis Pathobiology
Funded at University of Virginia · NIH-10892832 · Data updated 2026-11-12
This study is looking at aortic stenosis, a heart valve condition that often affects older adults, to better understand how it develops and to find new ways to treat it, which could help improve care for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | September 1, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $704,407 |
| NIH project number | 5R01HL165422-03 |
| Project ID | NIH-10892832 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are elderly individuals aged 65 and older who are diagnosed with or at risk for aortic stenosis.
✕Less likely to help
Patients who are younger than 65 or do not have aortic stenosis may not receive any benefit from this research.
What this research studies
This research focuses on understanding aortic stenosis, a condition that affects many elderly individuals, by utilizing advanced non-invasive imaging methods. The study aims to explore the biological processes that lead to the disease, particularly how certain cells in the heart valve change and contribute to the condition. By examining these changes in detail, the researchers hope to identify potential new treatments that could slow the progression of aortic stenosis. Patients may benefit from improved diagnostic techniques and future therapies that arise from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow the progression of aortic stenosis, improving outcomes for patients.
How similar studies have gone: Previous research has shown promise in using advanced imaging techniques to study heart conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Lindner, Jonathan R — University of Virginia
- Study coordinator: Lindner, Jonathan R
Related research
Other NIH-funded projects on the same topics.
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Investigating how stiffening of the aorta from elastin loss causes SVAS
A new NIH grant is exploring why elastin loss leads to supravalvular aortic stenosis and how abnormal smooth muscle cell signaling causes the aorta to narrow in children.
-
Risk prediction for aortic stenosis and how statins might help in adults 75 and older
This grant seeks to identify which adults over 75 are at high risk for aortic valve disease and how statin therapy could influence that risk.
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AI-powered screening and monitoring for aortic stenosis in older adults
A powerful new AI-based approach uses a simple heart rhythm test and a hand-held ultrasound to detect and monitor advanced aortic valve narrowing in people aged 65 and older.
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Linking normal aortic valve blood flow patterns to risk of aortic valve narrowing
This grant studies how normal differences in how the aortic valve moves and carries blood might influence who develops aortic stenosis.
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Chronic Kidney Disease and Aortic Valve Disease: Understanding How Kidney Disease Influences Aortic Stenosis
This grant looks at how chronic kidney disease may affect the progression of aortic stenosis and whether we can find ways to slow it down for adults with kidney issues.
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Advanced non-invasive imaging to understand aortic stenosis biology
Aging adults with aortic stenosis may benefit from new imaging-based research to slow disease progression and reduce need for valve procedures.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.