Investigating blood proteins to understand heart changes in aortic stenosis
Circulating Proteomics to Phenotype the Development and Reversal of Myocardial Remodeling in Aortic Stenosis
['FUNDING_R01'] · VANDERBILT UNIVERSITY MEDICAL CENTER · NIH-11014048
This study is looking at certain proteins in the blood to see how they relate to heart changes in older adults with aortic stenosis, hoping to find ways to spot problems early and improve treatment options for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (NASHVILLE, UNITED STATES) |
| Trial ID | NIH-11014048 on ClinicalTrials.gov |
What this research studies
This research focuses on identifying specific blood proteins that can help characterize the changes in the heart associated with aortic stenosis, a condition affecting many older adults. By analyzing these proteins, researchers aim to better understand how the heart remodels and potentially reverses damage before severe symptoms occur. The study will involve patients with varying degrees of aortic stenosis and will utilize advanced imaging techniques to correlate protein levels with heart function. This approach may lead to earlier interventions that could improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults diagnosed with aortic stenosis, particularly those in the early stages of the condition.
Not a fit: Patients with advanced aortic stenosis who are already experiencing severe symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more effective treatments for patients with aortic stenosis, potentially reducing heart failure symptoms and improving overall heart health.
How similar studies have performed: Previous research has shown promise in using proteomic analysis to understand heart conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
NASHVILLE, UNITED STATES
- VANDERBILT UNIVERSITY MEDICAL CENTER — NASHVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LINDMAN, BRIAN RICHARD — VANDERBILT UNIVERSITY MEDICAL CENTER
- Study coordinator: LINDMAN, BRIAN RICHARD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.