Investigating blood proteins to understand heart changes in aortic stenosis
Official title: Circulating Proteomics to Phenotype the Development and Reversal of Myocardial Remodeling in Aortic Stenosis
Funded at Vanderbilt University Medical Center · NIH-11014048 · Data updated 2026-11-12
This study is looking at certain proteins in the blood to see how they relate to heart changes in older adults with aortic stenosis, hoping to find ways to spot problems early and improve treatment options for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | April 1, 2023 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $706,491 |
| NIH project number | 5R01HL164526-03 |
| Project ID | NIH-11014048 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults diagnosed with aortic stenosis, particularly those in the early stages of the condition.
✕Less likely to help
Patients with advanced aortic stenosis who are already experiencing severe symptoms may not benefit from this research.
What this research studies
This research focuses on identifying specific blood proteins that can help characterize the changes in the heart associated with aortic stenosis, a condition affecting many older adults. By analyzing these proteins, researchers aim to better understand how the heart remodels and potentially reverses damage before severe symptoms occur. The study will involve patients with varying degrees of aortic stenosis and will utilize advanced imaging techniques to correlate protein levels with heart function. This approach may lead to earlier interventions that could improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more effective treatments for patients with aortic stenosis, potentially reducing heart failure symptoms and improving overall heart health.
How similar studies have gone: Previous research has shown promise in using proteomic analysis to understand heart conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Lindman, Brian Richard — Vanderbilt University Medical Center
- Study coordinator: Lindman, Brian Richard
Related research
Other NIH-funded projects on the same topics.
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Investigating how stiffening of the aorta from elastin loss causes SVAS
A new NIH grant is exploring why elastin loss leads to supravalvular aortic stenosis and how abnormal smooth muscle cell signaling causes the aorta to narrow in children.
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Risk prediction for aortic stenosis and how statins might help in adults 75 and older
This grant seeks to identify which adults over 75 are at high risk for aortic valve disease and how statin therapy could influence that risk.
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AI-powered screening and monitoring for aortic stenosis in older adults
A powerful new AI-based approach uses a simple heart rhythm test and a hand-held ultrasound to detect and monitor advanced aortic valve narrowing in people aged 65 and older.
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Linking normal aortic valve blood flow patterns to risk of aortic valve narrowing
This grant studies how normal differences in how the aortic valve moves and carries blood might influence who develops aortic stenosis.
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Chronic Kidney Disease and Aortic Valve Disease: Understanding How Kidney Disease Influences Aortic Stenosis
This grant looks at how chronic kidney disease may affect the progression of aortic stenosis and whether we can find ways to slow it down for adults with kidney issues.
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Advanced non-invasive imaging to understand aortic stenosis biology
Aging adults with aortic stenosis may benefit from new imaging-based research to slow disease progression and reduce need for valve procedures.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.