Understanding how aortic stenosis progresses and who is at risk

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study follows a large cohort of adults with moderate aortic stenosis to identify biomarkers and imaging features that predict progression to severe disease. Researchers will analyze morphological, functional, genetic, and immunological data to see which factors best forecast worsening valve function. The goal is to identify high-risk patients who might benefit from earlier intervention and to explore options to slow progression. The study builds on previous work showing inflammation and calcification play roles in aortic valve disease.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* The patient has an acquired (tricuspid) moderate aortic valve stenosis, which is the reason for regular outpatient cardiological care.
* The subject has been informed verbally and in writing about the study and has given written consent to participate in this study.
* Age \> 18 years

Exclusion Criteria:

* The subject has contraindications for the performance of a magnetic resonance imaging or computed tomography (e.g., severe arrhythmias , contrast agent intolerance, a pacemaker, or severe renal insufficiency or severe renal insufficiency or claustrophobia).
* Presence of only mild or already high-grade acquired tricuspid Aortic valve stenosis
* Patient with bicuspid aortic valve
* Inability to follow the instructions of study personnel
* Lack of written informed consent

Where it's running

• University-Hospital Bonn
  Bonn, Germany Recruiting
• University Hospital Cologne
  Cologne, Germany Recruiting
• University-Hospital Düsseldorf Division of Cardiology, Pulmonary Disease and Vascular Medicine
  Düsseldorf, Germany Recruiting

Study contacts

• Study coordinator: Tobias Zeus, MD
• Email: zeus@med.uni-duesseldorf.de
• Phone: +4921118800

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Echo-AVCS: Drawing AI-powered clues from heart scans to confirm severe aortic stenosis

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  Recruiting at 4 sites Azienda Ospedaliera "Sant'Andrea" · Bologna and 4 other locations · NCT07620925

• TAVI without on-site heart surgery: can selected centers do it safely?

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• Willem AI for early detection of aortic stenosis from a 12‑lead ECG

  This project will test whether the Willem AI can detect aortic stenosis from routine 12‑lead ECGs in adults.

  Recruiting at 2 sites Idoven 1903 S.L. · Bonn and 1 other locations · NCT07479992

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.