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Clinical trials and research at VA Office of Research and Development

• 268Clinical trials
• 1Country

Newest trials

All recruiting trials (newest 150 of 268)

• taVNS for knee osteoarthritis in Veterans

  This study tests whether home-based transcutaneous auricular vagus nerve stimulation (taVNS) can relieve knee OA pain and reduce inflammation in Veterans, comparing it with corticosteroid injections.

  Recruiting VA Office of Research and Development · Decatur, Georgia · NCT07804199

• Honest, Open, Proud for justice-involved veterans

  This trial tests a peer-delivered stigma-reduction program for veterans with co-occurring mental health or substance use disorders who are involved with the justice system, to see if different delivery intensities help more veterans engage in care.

  Recruiting VA Office of Research and Development · Bedford, Massachusetts · NCT07742722

• Tailor a Hand Hygiene Bundle for Acute Mental Health Care

  We’re testing a new hand hygiene approach in VA mental health inpatient units to see if a tailored bundle and non-alcohol sanitizer can improve cleanliness and reduce infections.

  Recruiting at 4 sites VA Office of Research and Development · Hines, Illinois and 3 other locations · NCT07607145

• Using smartphone video to measure knee movement in osteoarthritis

  This project will test whether a smartphone video system called OpenCap can measure knee movement and mechanics in people with early knee osteoarthritis and how those measurements compare with lab motion capture, symptoms, and knee imaging.

  Recruiting VA Office of Research and Development · Palo Alto, California · NCT07580222

• Care coordination with passive mobile monitoring to help veterans with serious mental illness

  This project tests a care-coordination approach that uses passive mobile data and peer coaching to help veterans with serious mental illness avoid emergency care and stay connected with their care teams.

  Recruiting at 2 sites VA Office of Research and Development · West Los Angeles, California and 1 other locations · NCT07549178

• Adaptive peer-supported mobile health for veterans with psychological distress

  This study tests whether matched amounts of peer support help Veterans use mHealth tools to reduce psychological distress.

  Recruiting VA Office of Research and Development · Palo Alto, California and 4 other locations · NCT07507747

• Facilitating Tobacco Treatment in Veterans with Serious Mental Illness

  This project tests an external facilitation approach to help VA clinics prescribe smoking medications more often to Veterans with serious mental illness who smoke.

  Recruiting VA Office of Research and Development · Baltimore, Maryland · NCT07455526

• PEP Buddy in COPD Pulmonary Rehabilitation

  This trial tests whether a breathing-assist device (PEP Buddy) helps veterans with COPD improve symptoms and exercise capacity during and after pulmonary rehabilitation more quickly than a sham device.

  Recruiting VA Office of Research and Development · Cincinnati, Ohio and 1 other locations · NCT07404826

• Motivational Interviewing plus Cognitive Behavioral Therapy to help homeless-experienced Veterans re-engage with work and community activities

  This project tests a combined motivational interviewing and cognitive behavioral therapy approach to help homeless-experienced Veterans who are now housed to pursue work, school, or training.

  Recruiting VA Office of Research and Development · West Los Angeles, California · NCT07388641

• Expanding Veteran Sponsorship Initiative+ to help high-risk service members and veterans transition to civilian life using personalized risk tools

  This project tests whether matching soon-to-be-discharged service members and young veterans to VA-certified peer sponsors, guided by personalized risk predictions, helps reduce reintegration problems and suicide risk.

  Recruiting VA Office of Research and Development · The Bronx, New York · NCT07356492

• I-SLEPT: Integrated Sleep and Life Engagement for Transitions

  This project tests a sleep and life-engagement program designed to help Veterans re-adjust after hospital discharge.

  Recruiting VA Office of Research and Development · Boston, Massachusetts · NCT07317336

• Cognitive rehabilitation to help veterans with psychogenic nonepileptic seizures (PNES)

  This program will try a telehealth cognitive rehabilitation workbook and sessions (CRAFT) to help U.S. veterans with PNES improve thinking skills and everyday functioning.

  Recruiting VA Office of Research and Development · Providence, Rhode Island · NCT07316543

• Using VA Peer Specialists to Help Prevent Veteran Suicide

  This study tests whether 12 one-on-one sessions with a VA Peer Specialist over 3 months can help reduce suicide risk among Veterans with serious mental illness.

  Recruiting at 2 sites VA Office of Research and Development · Baltimore, Maryland and 2 other locations · NCT07286383

• Slope Adaptive Foot to help veterans with below-knee amputation participate more in daily life

  Tests a new slope-adaptive foot to see if it helps veterans with below-knee amputation walk more comfortably and participate in activities, compared with a standard hydraulic foot.

  Recruiting VA Office of Research and Development · Minneapolis, Minnesota · NCT07266077

• Psilocybin for Treatment-Resistant Depression in Veterans

  This study tests whether psilocybin can help U.S. military veterans with treatment-resistant depression, with or without PTSD.

  Recruiting at 5 sites Phase 3 VA Office of Research and Development · Birmingham, Alabama and 4 other locations · NCT07226232

• Spinal Neurorehabilitation for Veterans With SCI

  This study tests non-invasive spinal neuromodulation approaches to see if veterans with long-term spinal cord injury can gain some motor or sensory improvements.

  Recruiting VA Office of Research and Development · Sacramento, California · NCT07222046

• MyHealtheBladder: a mobile bladder health app for Women Veterans

  This project will test a mobile app that teaches bladder-control techniques for Women Veterans with urinary incontinence to see which rollout method reaches more people and helps manage symptoms.

  Recruiting VA Office of Research and Development · Durham, North Carolina · NCT07219433

• See if semaglutide helps reduce risky drinking in veterans with alcohol use disorder

  This trial tests whether weekly injections of semaglutide can help veterans with moderate to severe alcohol use disorder drink less compared to placebo over 24 weeks.

  Recruiting at 18 sites Phase 3 VA Office of Research and Development · Long Beach, California and 18 other locations · NCT07218354

• SWELL cognitive behavioral therapy program for chronic insomnia in older Veterans

  This project will try two ways of rolling out SWELL, a five-session CBT for chronic insomnia, to help older Veterans get and benefit from treatment.

  Recruiting VA Office of Research and Development · Durham, North Carolina · NCT07216261

• Group physical therapy for Veterans with knee osteoarthritis

  This project will test two ways of implementing group physical therapy for Veterans with knee osteoarthritis across VA clinics to see which approach helps sites start and run the program successfully.

  Recruiting VA Office of Research and Development · Durham, North Carolina · NCT07215572

• Central Sleep Apnea in Heart Failure: How Mechanisms May Guide Treatment

  This study tests whether combining positive airway pressure with a medication (trazodone) or oxygen can reduce central sleep apnea in Veterans with heart failure and ensure better breathing during sleep.

  Recruiting Phase 4 VA Office of Research and Development · Detroit, Michigan · NCT07210606

• Measurement-based care to improve quality of life and disease management in Veterans with inflammatory bowel disease

  The trial will test whether regularly collecting and acting on Veterans' symptom reports helps people with inflammatory bowel disease feel better and have fewer flares over 12 months.

  Recruiting VA Office of Research and Development · Decatur, Georgia and 3 other locations · NCT07210580

• Virtual group exercise and health education to lower fall risk in older Veterans with obesity and low muscle

  This program tests whether a live virtual group exercise program plus health education can lower fall risk and increase daily activity for Veterans aged 55 and older with obesity and signs of sarcopenia.

  Recruiting VA Office of Research and Development · Baltimore, Maryland · NCT07206368

• Goal‑directed telehealth training to improve attention and executive function in veterans with chronic TBI

  This project will try video telehealth training that practices attention and executive skills to help veterans with chronic mild-to-moderate TBI improve community reintegration.

  Recruiting VA Office of Research and Development · Palo Alto, California · NCT07190365

• Whole Health Coaching added to VA pain management teams for Veterans with chronic pain

  This trial tests whether adding Whole Health Coaching to VA pain management teams helps Veterans on long-term opioids improve function and use opioids more safely.

  Recruiting at 4 sites VA Office of Research and Development · Birmingham, Alabama and 4 other locations · NCT07149870

• Function-focused Transitional Care for Veterans After Hospitalization

  This project tests a function-focused version of the CTraC transitional care program to help Veterans regain and maintain independence after leaving the hospital.

  Recruiting VA Office of Research and Development · Boston, Massachusetts · NCT07132944

• MDMA-assisted therapy for veterans with PTSD and alcohol use disorder

  This study tests MDMA-assisted therapy versus a low-dose MDMA placebo with psychotherapy to see if it helps veterans who have PTSD and problem drinking.

  Recruiting at 2 sites Phase 2/3 VA Office of Research and Development · West Haven, Connecticut and 1 other locations · NCT07118839

• Repetitive Transcranial Magnetic Stimulation for Stimulant Use Disorder in Veterans

  A randomized, placebo-controlled test to see if rTMS helps veterans with stimulant use disorder see reduced use and improved outcomes.

  Recruiting VA Office of Research and Development · Palo Alto, California · NCT07112105

• Targeting the hip muscles to reduce falls with a live virtual balance program before Gerofit

  This study tests whether a live, home-based, multimodal balance program focused on hip muscles before the Gerofit exercise program can better reduce falls in older veterans at risk for falling.

  Recruiting VA Office of Research and Development · Baltimore, Maryland · NCT07109466

• Helping Veterans with unemployment try a combined vocational program for better jobs

  A program that adds Purposeful Pathways to the standard Transitional Work model is being tested to see if it helps veterans with mental health and substance use issues find better, more stable employment.

  Recruiting VA Office of Research and Development · Hines, Illinois and 2 other locations · NCT07097376

• Improving Veteran Referral to Cardiac Rehabilitation

  This project tests whether a Veteran Cardiac Rehabilitation Referral Program helps more eligible veterans get referrals and start cardiac rehabilitation.

  Recruiting at 3 sites VA Office of Research and Development · Gainesville, Florida and 2 other locations · NCT07079358

• Improving thinking, daily functioning, mood, and sleep after mild traumatic brain injury and PTSD

  This project will test whether adding morning bright light therapy to compensatory cognitive training helps post-9/11 Veterans with mild traumatic brain injury and PTSD think, function, and sleep better compared with a neutral ion generator.

  Recruiting at 2 sites VA Office of Research and Development · San Diego, California and 1 other locations · NCT07055633

• Personalized Brain Stimulation to Help Veterans Quit Smoking

  This study tests two personalized brain-stimulation approaches to help veterans quit smoking.

  Recruiting VA Office of Research and Development · Charleston, South Carolina · NCT07050862

• Helping Veterans with chronic disease reduce smoking and risky drinking

  This program will test whether a mailed, tailored education packet plus a brief motivational phone call helps Veterans with diabetes, heart disease, or related risk factors who smoke or drink too much become more motivated to change.

  Recruiting Phase 3 VA Office of Research and Development · Buffalo, New York · NCT07039175

• PSMA PET/CT for staging and managing hepatocellular carcinoma

  PSMA PET/CT will be tried alongside standard CT or MRI to see if it improves diagnosis, staging, and tracking of treatment response for adults with suspected or confirmed hepatocellular carcinoma.

  Recruiting at 2 sites VA Office of Research and Development · West Los Angeles, California and 1 other locations · NCT07019844

• Adaptive Cognitive Processing Therapy (CPT) Therapist Training

  This project tests different sequences of training methods to find the best way to help VA therapists learn and stick to Cognitive Processing Therapy so Veterans with PTSD get higher-quality care.

  Recruiting at 4 sites VA Office of Research and Development · Palo Alto, California and 3 other locations · NCT07010770

• Integrated PTSD and weight-management program for Veterans with obesity.

  This program will test whether combining PTSD therapy with behavioral and medication-supported weight management helps Veterans with PTSD and obesity lose weight and reduce PTSD symptoms.

  Recruiting VA Office of Research and Development · Seattle, Washington · NCT07010757

• Measuring stability in Veterans with lower limb loss

  This study tests a new way to measure balance in Veterans with lower limb loss to see if it can help improve their mobility and quality of life during rehabilitation.

  Recruiting VA Office of Research and Development · New York, New York · NCT06987019

• Varenicline-based approach to help Veterans who smoke see if they can reduce smoking and try to quit

  This study tests whether varenicline, plus motivational support, helps Veterans who aren’t ready to quit reduce smoking and make quit attempts.

  Recruiting at 3 sites Phase 4 VA Office of Research and Development · San Diego, California and 3 other locations · NCT06966362

• Which anticoagulant is safer and more effective for AF patients: apixaban vs rivaroxaban?

  This study tests whether apixaban or rivaroxaban is safer and similarly effective for preventing strokes in older veterans with atrial fibrillation.

  Recruiting at 5 sites Phase 4 VA Office of Research and Development · West Los Angeles, California and 8 other locations · NCT06953726

• Understanding long-term cognitive effects of COVID-19 in Veterans

  This study is trying to understand how COVID-19 affects the thinking and mental health of Veterans over time to help find better treatments for those struggling with these issues.

  Recruiting VA Office of Research and Development · Portland, Oregon and 1 other locations · NCT06932237

• Calm Moms-V: a trauma-informed web program for pregnant Veterans

  This program tests whether Calm Moms-V, a web-based CBT program, can reduce anxiety, stress, and low mood in pregnant Veterans with a history of trauma.

  Recruiting VA Office of Research and Development · New Orleans, Louisiana · NCT06906185

• Enhancing Veteran-Clinician Collaboration in VA Care for Serious Mental Illness

  This study tests a 10-session group program to help Veterans with serious mental illness collaborate better with their clinicians and care teams.

  Recruiting VA Office of Research and Development · San Diego, California and 2 other locations · NCT06898879

• Pharmacist-led urate-lowering care to reach target in gout patients

  This study tests whether a pharmacist-led, telehealth approach to ULT management helps veterans with gout reach uric acid goals and reduce flare burden compared with usual care.

  Recruiting at 5 sites VA Office of Research and Development · Omaha, Nebraska and 4 other locations · NCT06887452

• Home-based vision therapy for post-concussive near-vision problems

  We will test a virtual-reality home training game to help Veterans with convergence insufficiency after concussion improve near vision and reduce double vision.

  Recruiting Phase 1 VA Office of Research and Development · Cleveland, Ohio · NCT06886737

• Optimizing Deep Brain Stimulation to Improve Vision in Parkinson's

  This study tests how adjusting deep brain stimulation in the subthalamic region can improve eye alignment and depth perception in people with Parkinson's disease.

  Recruiting VA Office of Research and Development · Cleveland, Ohio · NCT06857851

• Brain imaging and a single lorazepam dose to find veterans with high‑arousal PTSD who respond to GABA‑targeting drugs

  This project will test whether a single low dose of lorazepam combined with brain imaging and a computer task can identify veterans with PTSD and high anxious arousal who might benefit from GABA‑targeting medications.

  Recruiting Phase 4 VA Office of Research and Development · San Diego, California · NCT06852469

• Cognitive-sensorimotor effects on walking and balance after long COVID

  This project will test whether thinking, vision, sensation, and muscle changes explain walking and balance problems in adults with long COVID.

  Recruiting VA Office of Research and Development · Chicago, Illinois · NCT06850350

• Improving skeletal muscle in Veterans with HIV

  This will test whether switching saturated fats to unsaturated fats, giving L‑carnitine and omega‑3 supplements, and adding targeted resistance exercise can reduce fat in muscle and improve muscle health in Veterans with HIV and obesity.

  Recruiting VA Office of Research and Development · Nashville, Tennessee · NCT06845046

• Boosting precision cancer testing for veterans with advanced prostate or lung cancer

  This program will try a three-part approach—short patient education, provider feedback, and an easier EMR ordering system—to increase molecular testing for veterans with advanced prostate or lung cancer at eight VA centers.

  Recruiting VA Office of Research and Development · New York, New York · NCT06825715

• Focused ultrasound to help veterans with PTSD

  This study tests a non-invasive brain treatment using low intensity focused ultrasound to see if it can reduce PTSD symptoms and improve daily functioning in veterans.

  Recruiting Phase 2 VA Office of Research and Development · Providence, Rhode Island · NCT06820138

• Qnnections: a 10-week group program to build social connection for LGBTQ+ and other minoritized Veterans

  This project will test whether Qnnections, a 10-week group program, can increase social connection and reduce suicide risk for LGBTQ+ and other minoritized Veterans who have recent suicidal thoughts or behavior.

  Recruiting VA Office of Research and Development · San Diego, California · NCT06803329

• MOVED: a web-based mood-elevating program for Veterans with PTSD

  This study tests MOVED, a web-based, self-guided program to see if it can reduce PTSD symptoms and improve social functioning and quality of life for Veterans compared with a neutral, supportive control.

  Recruiting VA Office of Research and Development · Temple, Texas · NCT06788678

• Orexin-blocking treatment to help fear extinction in PTSD and insomnia

  This study tests whether suvorexant, a sleep medication that blocks orexin receptors, helps people with PTSD and insomnia by improving fear extinction learning.

  Recruiting Phase 4 VA Office of Research and Development · San Francisco, California and 1 other locations · NCT06788522

• Using topical imipramine with photodynamic therapy for skin lesions in veterans

  This study is testing if using a skin cream called imipramine along with light therapy can help veterans with precancerous skin lesions get better results from their treatment.

  Recruiting Phase 2 VA Office of Research and Development · Dayton, Ohio · NCT06778434

• Cognitive Behavioral Therapy for Chronic Pain in Veterans with Serious Mental Illness

  This study will test whether Cognitive Behavioral Therapy for Chronic Pain (CBT-CP) helps Veterans with serious mental illness and chronic low back pain reduce pain-related interference and improve quality of life.

  Recruiting VA Office of Research and Development · Baltimore, Maryland · NCT06758414

• Inclined walking versus standard treadmill walking for people with COPD

  This trial will test whether walking on an incline during pulmonary rehabilitation helps people with COPD breathe and walk with less shortness of breath compared to walking faster on a flat treadmill.

  Recruiting VA Office of Research and Development · Omaha, Nebraska · NCT06749262

• Trauma-informed telehealth exercise program for women veterans with histories of sexual violence

  We will try a trauma-informed telehealth exercise program for women veterans who experienced sexual violence to see if it improves their physical, mental, and daily functioning.

  Recruiting at 2 sites VA Office of Research and Development · Boston, Massachusetts and 1 other locations · NCT06746740

• Empagliflozin to reduce arterial stiffness in veterans with obesity

  This 12-week trial will test whether taking empagliflozin can reduce arterial stiffness in veterans with obesity compared with a placebo.

  Recruiting Phase 2 VA Office of Research and Development · Columbia, Missouri · NCT06745063

• Virtual nutrition and cooking program to improve diet and social engagement for older Veterans with impaired mobility.

  This trial will test whether a three-month virtual group nutrition program with produce delivery and cooking demonstrations can improve diet, quality of life, and muscle strength in Veterans over 65 with impaired mobility.

  Recruiting VA Office of Research and Development · Baltimore, Maryland · NCT06726083

• Biomarker-directed temozolomide plus stenoparib versus lurbinectedin for relapsed small cell lung cancer

  This trial tests whether adding the oral drug stenoparib to temozolomide works better than standard lurbinectedin for people with relapsed small cell lung cancer and whether a blood biomarker can help pick who will benefit.

  Recruiting at 6 sites Phase 1/2 VA Office of Research and Development · Palo Alto, California and 10 other locations · NCT06681220

• Simulator training to improve driving after stroke

  This project will test whether active, skills-focused driving-simulator training helps Veteran stroke survivors drive better than extra time getting familiar with the simulator.

  Recruiting VA Office of Research and Development · Sacramento, California · NCT06672107

• Improving care for Veterans with non-alcoholic fatty liver disease

  This study tests a new way to help Veterans with non-alcoholic fatty liver disease by using a structured plan to improve diagnosis and treatment compared to regular care.

  Recruiting VA Office of Research and Development · Houston, Texas · NCT06671886

• Fasting-mimicking diet with immunotherapy for advanced non-small cell lung cancer

  This trial will test whether following a fasting-mimicking diet while receiving pembrolizumab helps people with advanced non-small cell lung cancer respond better and have fewer side effects.

  Recruiting at 4 sites VA Office of Research and Development · Long Beach, California and 3 other locations · NCT06671613

• Working memory training to improve fear extinction in veterans with PTSD

  This study is testing if a special memory training program can help veterans with PTSD learn to manage their fears better.

  Recruiting VA Office of Research and Development · San Diego, California · NCT06629064

• Exercise and brain responses to stress-related eating in veterans

  This study tests whether adding a structured exercise program for 12 weeks changes how veterans’ brains respond to thinking tasks and food images, and whether hormonal differences between men and women influence those brain changes.

  Recruiting VA Office of Research and Development · Aurora, Colorado · NCT06627569

• Empagliflozin to protect kidney and heart health after heart transplant

  This trial will test whether empagliflozin can protect kidney and heart health and improve metabolic and functional outcomes in Veterans who have had a heart transplant.

  Recruiting Phase 4 VA Office of Research and Development · Palo Alto, California and 5 other locations · NCT06625073

• HealthyTogether: Dyadic 14-week virtual weight-loss program for Veterans and a support person

  This program will see if a 14-week, eight-session virtual weight-loss program that includes Veterans and a close support person helps Veterans with obesity lose weight.

  Recruiting at 2 sites VA Office of Research and Development · Aurora, Colorado and 1 other locations · NCT06619041

• Exercise and monitoring to improve muscle health in Veterans with chronic kidney disease

  This study is testing whether exercise and regular check-ins can help older Veterans with chronic kidney disease build strength and improve their overall health.

  Recruiting at 2 sites VA Office of Research and Development · Aurora, Colorado and 1 other locations · NCT06607913

• Preventing suicide after discharge from community mental health care

  This project will try the VA Brief Intervention and Contact Program (VA BIC) to see if it reduces suicidal thoughts and behaviors and improves care engagement for Veterans after discharge from non-VA acute psychiatric treatment.

  Recruiting VA Office of Research and Development · White River Junction, Vermont · NCT06596044

• Mobile program to reduce suicidal thoughts in Veterans.

  This pilot will try a brief mobile program called MIST to reduce harmful suicidal beliefs and thoughts in Veterans with recent suicidal ideation.

  Recruiting VA Office of Research and Development · Durham, North Carolina · NCT06593379

• Mindfulness training using virtual reality for veterans with spinal cord injuries

  This study is testing a virtual reality mindfulness program to see if it can help veterans with spinal cord injuries manage pain better and improve their quality of life.

  Recruiting VA Office of Research and Development · Houston, Texas · NCT06587607

• Improving rehabilitation for veterans with serious mental illness

  This study is testing a new computer program to help veterans with serious mental illnesses improve their thinking and daily life skills.

  Recruiting VA Office of Research and Development · San Diego, California · NCT06586164

• Personalized PATH plan for healthier use and recovery

  This project will try giving Veterans with substance use disorder a personal model of what causes their urges and substance use plus a one-hour feedback session to see if that helps their symptoms and recovery.

  Recruiting VA Office of Research and Development · Minneapolis, Minnesota · NCT06580457

• Safer pain treatment options for cancer survivors on long-term opioids

  This project will try four different approaches to lower long-term opioid use while keeping pain controlled in Veterans who are cancer survivors on chronic opioid therapy.

  Recruiting Phase 4 VA Office of Research and Development · Indianapolis, Indiana and 1 other locations · NCT06574009

• Preventing falls in older veterans

  This study is trying to see if a new program can help older veterans avoid falls by finding and managing their specific fall risks through different types of support and care.

  Recruiting VA Office of Research and Development · Aurora, Colorado · NCT06573983

• Atomoxetine for executive function in PTSD with ADHD in Veterans

  This trial tests whether atomoxetine can improve executive function in veterans with PTSD and attention problems compared with a placebo.

  Recruiting Phase 4 VA Office of Research and Development · Charleston, South Carolina · NCT06573970

• Using genetic testing to improve statin use in Veterans with high cholesterol

  This study is trying to see if genetic testing can help Veterans with high cholesterol better understand and stick to their statin medications to lower their risk of heart disease.

  Recruiting VA Office of Research and Development · Indianapolis, Indiana and 1 other locations · NCT06568601

• Non-invasive vagus nerve stimulation to improve walking and balance in Parkinson's

  This project will test whether a hand-held, at-home non-invasive vagus nerve stimulator can improve walking and reduce freezing of gait in Veterans with Parkinson's disease.

  Recruiting VA Office of Research and Development · Hines, Illinois · NCT06562569

• Helping Veterans choose the best in-person, phone, or video primary care visit

  This project will test interactive text messages for Veterans and brief coaching for their primary care clinicians to help Veterans pick whether an in-person, phone, or video visit is best for them.

  Recruiting VA Office of Research and Development · Ann Arbor, Michigan · NCT06539988

• Prediction-augmented lung cancer screening: a pragmatic VA trial

  This trial tests whether using prediction models to identify Veterans who would benefit most from lung cancer screening can be feasibly implemented at the point of care and increase screening uptake.

  Recruiting VA Office of Research and Development · Bedford, Massachusetts and 3 other locations · NCT06538636

• Preventing pressure injuries in veterans with spinal cord injuries

  This study is testing a new tool to help veterans with spinal cord injuries avoid pressure injuries by identifying their risks and needs better.

  Recruiting at 6 sites VA Office of Research and Development · Long Beach, California and 7 other locations · NCT06529094

• Continuing a BTK inhibitor alone versus adding venetoclax for veterans with CLL/SLL

  This will try adding venetoclax for one year to a BTKi in veterans with CLL or SLL who are already responding, to see if they can stop therapy safely compared with staying on BTKi alone.

  Recruiting at 4 sites Phase 2 VA Office of Research and Development · San Francisco, California and 3 other locations · NCT06520098

• Effects of soluble corn fiber on calcium absorption in older men

  This study is testing whether adding soluble corn fiber to the diet can help older men absorb more calcium and support their bone health.

  Recruiting Phase 2 VA Office of Research and Development · San Francisco, California · NCT06519877

• Assessing blood pressure treatment effects on arterial stiffness in older veterans

  This study is testing whether different blood pressure treatment goals can help reduce arterial stiffness in older veterans with high blood pressure.

  Recruiting VA Office of Research and Development · Birmingham, Alabama and 2 other locations · NCT06495710

• Maintaining knee improvement after physical therapy for Veterans

  This trial tests whether gamified social incentives and optional health coaching help Veterans with knee osteoarthritis stick with prescribed exercises and stay more active after physical therapy.

  Recruiting Phase 3 VA Office of Research and Development · Birmingham, Alabama and 4 other locations · NCT06488144

• Dronabinol for obstructive sleep apnea

  This two-week treatment will test whether taking oral dronabinol lowers sleep apnea events in adults aged 18–65 with moderate-to-severe obstructive sleep apnea.

  Recruiting Phase 1/2 VA Office of Research and Development · Chicago, Illinois · NCT06477952

• Improving sleep for Veterans with traumatic brain injury, PTSD, and chronic pain

  We will try morning bright light therapy at home to improve sleep for Veterans who have TBI, PTSD, and chronic pain.

  Recruiting VA Office of Research and Development · Portland, Oregon · NCT06477796

• Improving social engagement and connectedness among veterans

  This study is testing a new program to help veterans feel less isolated and more connected to others by providing support and resources through telehealth over eight weeks.

  Recruiting VA Office of Research and Development · Indianapolis, Indiana · NCT06467214

• Smartphone app to help Veterans with opioid use disorder

  This study is testing a new smartphone app designed to help Veterans with opioid use disorder by providing support and tools for their treatment.

  Recruiting VA Office of Research and Development · West Haven, Connecticut · NCT06454903

• Personalized exercise programs to lower dementia risk in older Veterans with Motoric Cognitive Risk

  This trial will try personalized exercise programs—functional power training, music-based walking, or both—to see if they help older Veterans with Motoric Cognitive Risk improve walking and thinking and lower dementia risk.

  Recruiting VA Office of Research and Development · Boston, Massachusetts · NCT06451874

• Pain and Smoking: A Program to Help Veterans Quit Smoking with Chronic Pain

  This study tests whether the PASS2 program, which adds nightly surveys to a pain-and-smoking cessation intervention, helps Veterans with chronic pain quit smoking better than usual care.

  Recruiting VA Office of Research and Development · West Haven, Connecticut · NCT06442514

• Helping Veterans quit smoking during cancer care

  This study is testing a new program to help Veterans quit smoking while they are being screened or treated for lung cancer.

  Recruiting VA Office of Research and Development · San Francisco, California · NCT06432985

• NightWare for reducing nightmares and supporting heart health in Veterans with PTSD

  This trial will test whether a prescription wrist-wearable app called NightWare can reduce PTSD-related nightmares and improve sleep and cardiovascular health in Veterans.

  Recruiting VA Office of Research and Development · Aurora, Colorado · NCT06419959

• Ketamine-assisted integrative treatment for Veterans with chronic low back pain and depression

  This pilot tests whether ketamine infusions followed by a brief behavioral program can reduce pain interference and improve mood in Veterans with chronic low back pain and depression.

  Recruiting Phase 2 VA Office of Research and Development · Ann Arbor, Michigan · NCT06419439

• Auricular neuromodulation for veterans with fibromyalgia

  This study is testing if a new ear-based treatment can help veterans with fibromyalgia feel less pain and move better compared to a fake treatment.

  Recruiting VA Office of Research and Development · Decatur, Georgia · NCT06415591

• Understanding balance issues in Veterans with Parkinson's Disease

  This study looks at how balance problems affect Veterans with Parkinson's Disease to see if new treatments can help them stay steady on their feet and avoid falls.

  Recruiting VA Office of Research and Development · Minneapolis, Minnesota · NCT06405334

• Improving identification and management of functional impairment in older veterans

  This study is testing a new way to help older veterans identify and manage difficulties they have with daily activities to improve their overall care and access to services.

  Recruiting VA Office of Research and Development · Philadelphia, Pennsylvania · NCT06404970

• Gait training to improve walking balance after stroke

  This study is testing a new robotic device to see if it can help people who have had a stroke improve their walking balance better than regular balance training.

  Recruiting VA Office of Research and Development · Chicago, Illinois and 1 other locations · NCT06400186

• Non-invasive vagus nerve stimulation for treating alcohol use disorder in veterans

  This study is testing if a new treatment using non-invasive vagus nerve stimulation can help veterans with alcohol use disorder by reducing their cravings and withdrawal symptoms.

  Recruiting VA Office of Research and Development · San Diego, California · NCT06399653

• Using a smartphone app to help prevent suicide in veterans after hospital discharge

  This study is testing a smartphone app designed to help prevent suicide in veterans after they leave the hospital by providing support and resources to manage their mental health.

  Recruiting VA Office of Research and Development · Ann Arbor, Michigan · NCT06378541

• Weight loss and exercise program for stroke survivors

  This study tests whether a 15-week weight loss and exercise program can help obese Veterans who have had a stroke feel better and recover more effectively.

  Recruiting VA Office of Research and Development · Charleston, South Carolina · NCT06322030

• Improving Vascular Function in Veterans with Heart Failure

  This study is testing whether a combination of L-Citrulline, BH4, and atorvastatin can help improve blood flow and physical ability in Veterans with heart failure.

  Recruiting Phase 1 VA Office of Research and Development · Salt Lake City, Utah · NCT06312748

• Comparing hearing aid fitting methods for veterans exposed to blasts

  This study is testing two different ways to fit hearing aids for veterans with blast-related injuries to see which method helps them hear better and feel more comfortable.

  Recruiting VA Office of Research and Development · Loma Linda, California and 2 other locations · NCT06309264

• Using a smartphone app with medications to help Veterans manage heavy drinking

  This study is testing if using a smartphone app along with medication can help Veterans with heavy drinking manage their alcohol use better than just medication alone.

  Recruiting at 15 sites VA Office of Research and Development · Phoenix, Arizona and 14 other locations · NCT06303778

• Assessing the impact of COVID-19 on sleep and cognitive health

  This study is trying to see how COVID-19 affects sleep and thinking in people who have recovered from the virus, to better understand long-term health issues they might face.

  Recruiting VA Office of Research and Development · Detroit, Michigan · NCT06291870

• Telerehabilitation program for veterans with complex health conditions

  This study tests a new online rehabilitation program for older veterans with multiple health issues to see if it helps them improve their physical activity and overall health better than standard education.

  Recruiting VA Office of Research and Development · Aurora, Colorado · NCT06288438

• Noninvasive stimulation of the vagus nerve to improve motor learning after stroke

  This study is testing if a new way to stimulate the vagus nerve through the ear can help people who have had a stroke improve their motor skills and learn better.

  Recruiting VA Office of Research and Development · Pittsburgh, Pennsylvania · NCT06282406

• Using immunotherapy for veterans with lung cancer

  This study is testing if a combination of chemotherapy and immunotherapy can help veterans with advanced lung cancer feel better and live longer.

  Recruiting at 7 sites Phase 2 VA Office of Research and Development · West Haven, Connecticut and 6 other locations · NCT06275360

• Program to help Veterans transition to cardiac rehabilitation

  This study tests a new program designed to help Veterans with heart issues join and stick with home-based rehabilitation to see if it improves their health and daily living.

  Recruiting at 2 sites VA Office of Research and Development · Boston, Massachusetts and 1 other locations · NCT06244199

• Using ketamine to treat depression in veterans with Parkinson's disease

  This study is testing if intravenous ketamine can help veterans with Parkinson's disease feel less depressed and improve their brain function.

  Recruiting Phase 2 VA Office of Research and Development · San Francisco, California · NCT06231563

• Telehealth program to manage pain and reduce opioid use in Veterans after surgery

  This study is testing a telehealth program to help Veterans manage pain and lower their use of opioids after orthopedic surgery.

  Recruiting VA Office of Research and Development · Salt Lake City, Utah · NCT06223503

• Evaluating the Ossur Power Knee for people with above-knee amputations

  This study is testing whether the Ossur Power Knee, a high-tech prosthetic knee that helps with movement, works better than a regular prosthetic knee for people with above-knee amputations.

  Recruiting VA Office of Research and Development · Chicago, Illinois · NCT06218238

• Internet-based depression intervention for veterans

  This study tests whether an online program called Deprexis can help veterans with mild to moderate depression feel better compared to standard treatment.

  Recruiting VA Office of Research and Development · Waco, Texas · NCT06217198

• Using mobile health technology to predict bipolar disorder episodes in veterans

  This study is testing a smartphone app that helps veterans with bipolar disorder spot early signs of mood episodes so they can get help before things get worse.

  Recruiting VA Office of Research and Development · Minneapolis, Minnesota · NCT06204705

• Using oxytocin to enhance couples therapy for veterans with PTSD

  This study is testing if adding a nasal spray of oxytocin to couples therapy can help veterans with PTSD and their partners feel better and improve their relationship.

  Recruiting Phase 2 VA Office of Research and Development · San Diego, California · NCT06194851

• Pregnenolone to improve function in Veterans with anxiety and depression

  This trial will test whether pregnenolone can help Veterans with anxiety and depression reduce symptoms and improve sleep, pain, and daily functioning.

  Recruiting Phase 2 VA Office of Research and Development · Durham, North Carolina · NCT06188923

• Improving hand strength and function in ALS patients using brain and spinal cord stimulation

  This study is testing a new way to help people with ALS improve their hand strength and function by using brain and spinal cord stimulation along with exercises.

  Recruiting VA Office of Research and Development · The Bronx, New York · NCT06172621

• Mindfulness training for Veterans with PTSD, depression, and anxiety

  This study is testing whether mindfulness training can help Veterans with PTSD, depression, and anxiety feel better compared to a regular problem-solving class.

  Recruiting at 3 sites VA Office of Research and Development · Phoenix, Arizona and 3 other locations · NCT06162741

• Understanding COVID-19 treatment effectiveness in Veterans

  This study looks at how well COVID-19 treatments work for Veterans with mild to moderate illness and compares those who receive treatment to those who don’t.

  Recruiting VA Office of Research and Development · Portland, Oregon · NCT06160128

• Water-based exercise and cognitive training for long COVID recovery

  This study is testing if a mix of water-based exercise and brain training can help Veterans with long COVID feel better and improve their neurological symptoms.

  Recruiting VA Office of Research and Development · Palo Alto, California · NCT06142253

• Mobile intervention to help homeless veterans with serious mental illness integrate into the community

  This study is testing a new mobile program to help homeless veterans with serious mental health issues better connect with their community and find stable housing.

  Recruiting VA Office of Research and Development · West Los Angeles, California · NCT06138054

• Effects of testosterone on nerve function in men with spinal cord injury

  This study tests if a single dose of intranasal testosterone can help improve nerve function in men with spinal cord injuries who have low testosterone levels.

  Recruiting Early Phase 1 VA Office of Research and Development · The Bronx, New York · NCT06130449

• Hearing aids for veterans with normal hearing sensitivity

  This study tests whether hearing aids can help veterans with normal hearing who still have trouble hearing and communicating, comparing their results to standard care.

  Recruiting VA Office of Research and Development · Portland, Oregon · NCT06117254

• Neurofeedback treatment for light sensitivity in veterans with mild brain injuries

  This study is trying a new neurofeedback treatment to see if it can help veterans with mild brain injuries who are sensitive to light feel better.

  Recruiting VA Office of Research and Development · Boston, Massachusetts · NCT06109909

• Exercise program to improve cognition in older Veterans

  This study is testing whether an exercise program can help improve thinking skills in older Veterans who may be dealing with memory problems or other health issues.

  Recruiting at 2 sites VA Office of Research and Development · West Los Angeles, California and 1 other locations · NCT06107842

• Home-based rehabilitation for phantom limb pain in veterans with amputations

  This study is testing a mobile app that helps veterans with amputations manage their phantom limb pain through home-based exercises and techniques.

  Recruiting VA Office of Research and Development · Minneapolis, Minnesota · NCT06106984

• Mobile intervention to reduce anger in Veterans with PTSD

  This study is testing a new mobile program designed to help Veterans with PTSD manage their anger better compared to a regular health education program.

  Recruiting VA Office of Research and Development · Durham, North Carolina · NCT06094933

• Non-invasive therapy for older veterans with spinal stenosis

  This study is testing a non-invasive therapy for older veterans with spinal stenosis to see if it can help them walk better and feel less pain without needing surgery.

  Recruiting VA Office of Research and Development · Baltimore, Maryland · NCT06089746

• Comparing different exercise volumes for veterans with moderate Parkinson's disease

  This study is testing whether veterans with moderate Parkinson's disease benefit more from high-volume dance exercise or moderate-volume walking to improve their physical activity and walking speed.

  Recruiting VA Office of Research and Development · Decatur, Georgia · NCT06088355

• Targeted radiation therapy for advanced prostate cancer without castration

  This study is testing a new combination of targeted radiation treatments for men with advanced prostate cancer to see if it helps them do better without the need for hormone therapy.

  Recruiting at 4 sites Phase 2 VA Office of Research and Development · West Los Angeles, California and 3 other locations · NCT06084338

• Electrical stimulation to improve bowel emptying

  This study tests if a new electrical stimulation method can help people with bowel problems from spinal cord injuries empty their bowels better than the usual digital stimulation method.

  Recruiting VA Office of Research and Development · Syracuse, New York · NCT06078176

• Understanding how to safely reduce steroid doses in rheumatoid arthritis patients

  This study is testing how safely and effectively people with rheumatoid arthritis can lower their steroid medication doses and what factors might make it easier or harder for them.

  Recruiting at 2 sites Phase 2 VA Office of Research and Development · Ann Arbor, Michigan and 1 other locations · NCT06072768

• Veteran-Centered Care for Advanced Liver Disease

  This study is testing a new way to care for Veterans with advanced liver disease by using telemedicine to help them talk about their health and treatment options to see if it leads to more discussions about liver transplants.

  Recruiting at 4 sites VA Office of Research and Development · Little Rock, Arkansas and 7 other locations · NCT06068491

• Predicting stroke rehabilitation outcomes with exercise

  This study is testing if certain tests can help figure out which stroke survivors with leg disabilities will benefit from a special exercise program to improve their walking and overall function.

  Recruiting VA Office of Research and Development · Decatur, Georgia · NCT06059872

• Digital intervention for Veterans with chronic pain

  This study tests whether an online therapy program for Veterans with chronic pain can help them manage their pain better than another online program.

  Recruiting VA Office of Research and Development · West Haven, Connecticut and 2 other locations · NCT06058624

• Home-based walking program for veterans with peripheral artery disease

  This study is testing two ways to deliver a home walking program for veterans with peripheral artery disease to see if it helps them walk farther and feel better.

  Recruiting VA Office of Research and Development · Birmingham, Alabama and 2 other locations · NCT06033924

• Evaluating caregiver transfer techniques for individuals with disabilities

  This study is testing how well caregivers help people with physical disabilities move and whether training can improve their techniques and reduce injuries.

  Recruiting VA Office of Research and Development · Pittsburgh, Pennsylvania · NCT06013878

• Using Empagliflozin to Improve Outcomes in Kidney Transplant Recipients

  This study is testing if the medication Empagliflozin can help improve kidney function and heart health in veterans who have received kidney transplants.

  Recruiting at 5 sites Phase 4 VA Office of Research and Development · Hines, Illinois and 4 other locations · NCT06013865

• Group psychological treatments via video for older veterans with chronic pain

  This study is testing three different video-based therapy options to see which one helps older veterans with chronic pain feel better.

  Recruiting at 2 sites VA Office of Research and Development · West Los Angeles, California and 1 other locations · NCT06004804

• Oxygen-guided exercise program for patients with peripheral artery disease

  This study tests a new exercise program that uses muscle oxygen levels to help people with peripheral artery disease walk better and feel healthier without the usual risks of traditional exercise.

  Recruiting VA Office of Research and Development · Omaha, Nebraska · NCT06003855

• Web-based program to help Veterans and their caregivers manage chronic conditions

  This study tests a web-based program to help Veterans with chronic illnesses and their caregivers manage stress and improve their health together.

  Recruiting VA Office of Research and Development · Palo Alto, California · NCT06001541

• Improving memory to help cognitive processing therapy work better for PTSD

  This study will try adding memory-support techniques to cognitive processing therapy to see if older Veterans with PTSD learn and retain therapy skills better.

  Recruiting VA Office of Research and Development · Philadelphia, Pennsylvania · NCT06000475

• Geriatric Out-of-hospital Meal Trial in Heart Failure for Veterans

  This trial tests whether adding home-delivered meals to standard post-discharge care helps veterans with heart failure recover better after hospitalization.

  Recruiting at 21 sites VA Office of Research and Development · Birmingham, Alabama and 20 other locations · NCT05996328

• Workshop to help recently transitioned Veterans reduce suicide risk and improve reintegration

  This study is testing a workshop designed to help Veterans transitioning to civilian life reduce their risk of suicide and improve their reintegration by teaching them practical skills and providing support.

  Recruiting VA Office of Research and Development · Boston, Massachusetts · NCT05995678

• A more comfortable, breathable transradial socket and harness for arm prostheses

  This project will test a new hybrid polymer-and-textile transradial socket and harness to see if it improves comfort, breathability, and function for people with a unilateral transradial amputation.

  Recruiting VA Office of Research and Development · Pittsburgh, Pennsylvania · NCT05990062

• Improving prosthetic socket fit for veterans with lower limb amputations

  This study is testing whether an adjustable prosthetic socket can help veterans with lower limb amputations walk better and feel more comfortable compared to a regular socket.

  Recruiting VA Office of Research and Development · Aurora, Colorado · NCT05989243

• Prism Adaptation Therapy for Stroke Rehabilitation

  This study is testing a new way to help Veterans with spatial neglect after a stroke by using brain scans to find out who would benefit most from a specific therapy that can improve their daily life.

  Recruiting at 4 sites VA Office of Research and Development · West Haven, Connecticut and 3 other locations · NCT05983185

• Evaluating treatments for suicidal veterans with PTSD

  This study is testing a new combined therapy for veterans with PTSD who are at risk of suicide to see if it works better than the usual treatment they currently receive.

  Recruiting at 4 sites VA Office of Research and Development · Minneapolis, Minnesota and 3 other locations · NCT05974631

• Exploring treatments for Gulf War Illness-related gastrointestinal symptoms

  This study is testing if taking glutamine can help veterans with Gulf War Illness feel better by easing their stomach problems like pain and diarrhea.

  Recruiting VA Office of Research and Development · Memphis, Tennessee · NCT05972291

Showing recruiting studies first, then the newest. Describe your situation to find the ones that fit you.

Quick answers

How many clinical trials run by VA Office of Research and Development are recruiting right now?

268, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

All of them have sites in United States. Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 25, Phase 4: 17, Phase 3: 8, Phase 1/2: 7. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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