Understanding long-term cognitive effects of COVID-19 in Veterans

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the long-term neuropsychiatric and neurological effects of COVID-19, specifically focusing on Veterans who experience cognitive impairments and mental health symptoms post-infection. Researchers will conduct a longitudinal assessment of cognitive function and psychiatric symptoms while evaluating biomarkers related to inflammation and neuropsychiatric function. The study will integrate clinical findings with biological data to identify potential biomarkers and clinical endpoints that could inform future therapeutic interventions for neuro-PASC.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Eligible participants will:

* have a history of SARS-CoV-2 infection 4 weeks prior to enrollment, defined as a positive PCR or home antigen test
* be able to give informed consent as determined by brief cognitive exam and evaluation of understanding of the risks, benefits, and voluntary nature of the study

Additionally, participants enrolled as part of the neuro-PASC group must also:

* currently experience neuro-PASC symptoms, not present prior to infection, as confirmed by the "Long COVID-19 Symptom Assessment" scale, a self-report measure that consists of 46 common COVID-19 sequela symptoms

Exclusion Criteria:

Exclusion criteria for all groups:

* diagnosed with dementia, traumatic brain injury, a neurological syndrome (e.g. Parkinson disease, Alzheimer disease), or other progressive cognitive disorder before SARS-CoV-2 infection
* diagnosed with a mood or psychotic disorder before SARS-CoV-2 infection
* history of fibromyalgia or chronic fatigue syndrome prior to SARS-CoV-2 infection
* unstable medical conditions or active uncontrolled autoimmune or inflammatory conditions

Where it's running

• VA Portland Health Care System, Portland, OR
  Portland, Oregon, United States Recruiting
• James H. Quillen VA Medical Center, Mountain Home, TN
  Mountain Home, Tennessee, United States Not yet recruiting

Study contacts

• Principal investigator: Jennifer M Loftis, MA PhD — VA Portland Health Care System, Portland, OR
• Study coordinator: Jennifer M Loftis, MA PhD
• Email: Jennifer.Loftis2@va.gov
• Phone: (503) 220-8262

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.