Neurofeedback treatment for light sensitivity in veterans with mild brain injuries

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot study aims to evaluate the feasibility and acceptability of a low-intensity pulse-based transcranial stimulation (LIP-tES) neurofeedback intervention to alleviate photosensitivity symptoms in veterans who have experienced mild traumatic brain injury (mTBI). Participants will undergo LIP-tES treatment while also receiving resting-state MRI scans to identify neurophysiological markers related to their photosensitivity. The study seeks to address the limitations of current treatments and explore the neurobiological underpinnings of photosensitivity in this population. By focusing on veterans, the study aims to provide insights into effective, non-invasive treatment options for a common and debilitating condition following mTBI.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Ages 18-65
* Documented history of mTBI at least 6 months prior to initial study visit
* Documented symptoms of photosensitivity
* Eye exam within the last 12 months documenting best-corrected acuity of 20/20 or better, normal pupillary function, color vision, no abnormalities on OCT scan, and normal Humphrey Visual Field test

Exclusion Criteria:

* History of strabismus or amblyopia
* Significant ocular media opacity that could reduce the amount of light entering the pupil in one or both eyes
* Previous or current history of retinal or optic nerve pathology in one or both eyes
* History of stroke and/or visual neglect
* History of neurodegenerative disease (e.g., Parkinson's, multiple sclerosis)
* History of epilepsy or seizures
* History of motor tics
* Current use of medications or substances that may severely affect pupillary response and/or increase photosensitivity
* Individuals with impaired decision-making capacity
* Illiterate or no English language proficiency

Where it's running

• VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
  Boston, Massachusetts, United States Recruiting

Study contacts

• Principal investigator: Francesca C Fortenbaugh, PhD — VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
• Study coordinator: Francesca C Fortenbaugh, PhD
• Email: Francesca.Fortenbaugh@va.gov
• Phone: (857) 364-4362

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.