Predicting stroke rehabilitation outcomes with exercise
Official title: What Makes a Responder, a Responder? Biomarkers to Help Identify Responders and Resistors to High-intensity Interval Training for Lower Extremity Chronic Stroke
Run by VA Office of Research and Development · NCT06059872 · Data updated 2026-11-12
This study is testing if certain tests can help figure out which stroke survivors with leg disabilities will benefit from a special exercise program to improve their walking and overall function.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 89 Years |
| Sex | All |
| Enrollment | 55 (estimated) |
| Sponsor | VA Office of Research and Development Federal |
| Locations | 1 site (Decatur, Georgia) |
| Status | Recruiting |
| Started | January 1, 2024 |
| Main results expected | June 1, 2027 |
| Study ends | December 1, 2027 |
| Registry record updated | March 27, 2026 |
| Trial ID | NCT06059872 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are Veterans who have experienced a chronic subcortical stroke and have lower extremity motor impairments affecting their walking speed.
✕Probably not a fit
Patients with neurodegenerative conditions other than stroke or those with contraindications for MRI may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to develop a predictive model to identify which stroke survivors with lower limb disabilities will benefit from high-intensity interval training (HIIT) rehabilitation. By analyzing biomarkers such as blood lactate levels, GABA concentrations, and regional cerebral blood flow, the researchers seek to enhance personalized rehabilitation strategies for chronic subcortical stroke patients. The study will also consider various factors including comorbidities, demographics, and fitness levels to tailor interventions effectively. The ultimate goal is to improve walking speed and overall function in these patients.
Why it matters
Potential benefit: If successful, this study could lead to more effective rehabilitation strategies for stroke survivors, enhancing their mobility and quality of life.
How similar studies have gone: While the approach of using biomarkers to predict rehabilitation outcomes is innovative, similar studies have shown promise in enhancing personalized rehabilitation strategies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * chronic left or right subcortical stroke as defined by 6 months or more after a cardiovascular accident * lower extremity motor impairment due to stroke that causes a walking speed of less than 0.6 m/s during a 10m walk * Veteran status Exclusion Criteria: * MRI contraindications, including implanted cardiac pacemakers and severe claustrophobia * any neurodegenerative condition other than stroke that may lead to lower extremity impairment * a visual or auditory impairment that may hinder study procedures * any medical condition that would preclude participation in a physical exercise intervention program
Where it's running
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Atlanta VA Medical and Rehab Center, Decatur, GA
Decatur, Georgia, United States Recruiting
Study contacts
- Principal investigator: Lisa C Krishnamurthy, PhD — Atlanta VA Medical and Rehab Center, Decatur, GA
- Study coordinator: Lisa C Krishnamurthy, PhD
- Email: Lisa.Krishnamurthy@va.gov
- Phone: (404) 321-6111
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Home-based vs. in-clinic upper extremity rehabilitation after stroke
This study tests whether a 20-hour home telerehabilitation program (tele-CPASS) works as well as the same in-clinic CPASS therapy for improving arm and hand function after stroke.
-
Balance and fall risk after stroke: Sensorimotor training versus whole-body vibration
A randomized study tests whether lower-limb sensorimotor training or whole-body vibration can improve balance and reduce fear of falling for people who have had a stroke.
-
Deep phenotyping to explore recovery in young adults after stroke
This project will test whether a detailed health and sample-collection approach (deep phenotyping) is practical and acceptable for people aged 18–55 who have had a stroke.
-
Brain pathways that support arm recovery after stroke
This trial will try 30 hours (over 6 weeks) of targeted Arm Basis Training versus usual care to see if it improves proximal arm motor control in people 3–6 months after a first ischemic or hemorrhagic stroke with moderate to severe arm impairment.
-
Digital rehabilitation system for stroke recovery
This study is testing a smartphone app that uses virtual and augmented reality to help stroke patients recover at home and see if it works better than regular therapy.
-
Stem cell therapy for chronic stroke recovery
This study is testing whether using a patient's own stem cells can help people with long-term stroke recovery feel better and improve their daily functioning.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.