Optimizing Deep Brain Stimulation to Improve Vision in Parkinson's

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational project examines how different DBS locations and settings in the subthalamic region affect vergence and strabismus in Parkinson's patients. researchers will combine patient-specific DBS models with high-resolution eye-tracking to identify stimulation locations and parameters that improve binocular coordination while maintaining motor benefits. The study uses existing DBS patients with bilateral STN implants and requires imaging availability to map brain targets. Findings could guide personalized DBS programming to help with vision-related symptoms alongside motor control. No intervention beyond current DBS management is prescribed in this observational framework.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Parkinson's disease with bilateral STN DBS
* Availability of pre-operative MR images (with a T1-weighted, gradient-echo sequence) and ability to get post-operative MRI or CT scans
* Hoehn and Yahr stage 2-4 when off medication, and a stable antiparkinsonian medication regimen and DBS parameter settings

Exclusion Criteria:

* Previous surgical therapy for Parkinson's disease (other than DBS)
* Dementia
* Clinically significant untreated depression or anxiety
* Clinical features suggestive of atypical parkinsonism

Where it's running

• Louis Stokes VA Medical Center, Cleveland, OH
  Cleveland, Ohio, United States Recruiting

Study contacts

• Principal investigator: Aasef G. Shaikh, MD PhD — Louis Stokes VA Medical Center, Cleveland, OH
• Study coordinator: Aasef G Shaikh, MD PhD
• Email: Aasef.Shaikh@va.gov
• Phone: (216) 791-3800

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.