Oxygen-guided exercise program for patients with peripheral artery disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project aims to assess the feasibility and acceptability of a muscle oxygen-guided supervised exercise program for patients suffering from peripheral artery disease (PAD). The intervention seeks to improve mobility and quality of life by allowing patients to engage in physical activity without the adverse effects associated with traditional supervised exercise therapy. By preventing cycles of ischemia and reperfusion during exercise, the study hopes to enhance walking performance and reduce cardiovascular risks. The research will compare the outcomes of this modified approach against standard exercise therapy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

At entry into the study, all subjects must:

* Be able to give written, informed consent
* Have documented lower extremity arterial occlusive disease based on ankle/brachial index measurements and/or arterial imaging
* Demonstrate positive history of chronic claudication
* Have a stable blood pressure regimen, stable lipid regimen, stable diabetes regimen and risk factor control for 6 weeks

Exclusion Criteria:

Any potential subjects will be excluded if they have:

* Rest pain or tissue loss due to PAD (Fontaine stage III and IV)
* Acute lower extremity ischemic event secondary to thromboembolic disease or acute trauma
* Walking capacity limited by conditions other than claudication including leg (joint/musculoskeletal, neurologic) and systemic (heart, lung disease) pathology

Where it's running

• Omaha VA Nebraska-Western Iowa Health Care System, Omaha, NE
  Omaha, Nebraska, United States Recruiting

Study contacts

• Principal investigator: Iraklis I Pipinos, MD — Omaha VA Nebraska-Western Iowa Health Care System, Omaha, NE
• Study coordinator: Farahnaz Fallahtafti, PhD
• Email: ffallahtafti@unomaha.edu
• Phone: (402) 995-3542

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.