Exercise program to improve cognition in older Veterans
Official title: Relationship of Exercise Frequency, Intensity, and Fitness to Improved Cognition and Biomarkers in Gerofit Participants
Run by VA Office of Research and Development · NCT06107842 · Data updated 2026-11-12
This study is testing whether an exercise program can help improve thinking skills in older Veterans who may be dealing with memory problems or other health issues.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 65 Years and up |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | VA Office of Research and Development Federal |
| Locations | 2 sites (West Los Angeles, California and 1 other locations) |
| Status | Recruiting |
| Started | April 1, 2024 |
| Main results expected | September 30, 2028 |
| Study ends | March 31, 2029 |
| Registry record updated | June 2, 2026 |
| Trial ID | NCT06107842 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are Veterans aged 65 and older who are eligible for the VA Gerofit program and have received clearance from their primary care provider.
✕Probably not a fit
Patients who are unable to perform activities of daily living or have significant cognitive impairment may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effects of the Gerofit exercise program on cognitive function in Veterans aged 65 and older. It aims to address the high prevalence of cognitive impairment and dementia among older Veterans, particularly those with comorbid conditions such as PTSD and depression. By incorporating physical activity and health education, the study seeks to enhance both physical and cognitive health outcomes. The research will also explore the predictive power of biomarkers related to exercise and cognition.
Why it matters
Potential benefit: If successful, this study could significantly improve the cognitive function and overall quality of life for older Veterans.
How similar studies have gone: Other studies have shown positive outcomes with exercise interventions in older adults, suggesting potential success for this approach in Veterans.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * All Veterans eligible for VA Gerofit program 65 years and older * Clearance by PCP to participate in Gerofit exercise program Exclusion Criteria: * Inability to perform ADLs * Significant cognitive impairment * Inability to function independently without assistance * Unstable angina; proliferative diabetic retinopathy * Oxygen dependent * Unwillingly to commute and/or not able to provide own transportation to Gerofit * Incontinence * Open wounds * Volatile behavioral issue or unable to work successfully in a group environment/setting * Active substance abuse * Homelessness
Where it's running
-
VA Greater Los Angeles Healthcare System, West Los Angeles, CA
West Los Angeles, California, United States Recruiting -
Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD
Baltimore, Maryland, United States Recruiting
Study contacts
- Principal investigator: Cathy C Lee, MD — VA Greater Los Angeles Healthcare System, West Los Angeles, CA
- Study coordinator: Cathy C Lee, MD
- Email: cathy.lee2@va.gov
- Phone: (310) 268-4110
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.