Noninvasive stimulation of the vagus nerve to improve motor learning after stroke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project investigates the effects of transcutaneous auricular vagus nerve stimulation (taVNS) on motor learning in individuals who have experienced a stroke. By applying electrical current to specific areas of the external ear, the study aims to activate neural pathways that may enhance learning and rehabilitation outcomes. The research focuses on understanding the physiological mechanisms involved in this process, particularly how taVNS influences brain states associated with learning. Participants will be compared against a sham stimulation group to assess the efficacy of the intervention.

Why it matters

Who can join: the full rules

Inclusion Criteria:

ALL PROSPECTIVE SUBJECTS:

1. 18-75 years of age

   PROSPECTIVE SUBJECTS DIAGNOSED WITH STROKE:
2. Diagnosis of a single stroke resulting in hand impairment
3. Diagnosis of stroke at least six months prior to the time of participation

Exclusion Criteria:

ALL PROSPECTIVE SUBJECTS:

1. History of vestibular disorders or dizziness
2. Difficulty maintaining alertness and/or remaining still
3. Pregnant or expecting to become pregnant
4. Diagnosis of neurological and/or musculoskeletal disorder(s) (other than stroke) that affect movement
5. Ocular disease and/or impairment in more than one eye
6. History of seizure and/or epilepsy
7. Implants, devices, or foreign objects in the brain/body that are incompatible with MRI
8. Body size that is incompatible with MRI scanner dimensions
9. Anyone already enrolled and actively participating in another greater than minimal risk study.

   PROSPECTIVE SUBJECTS DIAGNOSED WITH STROKE:
10. Other impairments secondary to stroke (e.g., attention, cognition, etc.) that would interfere with the ability to understand study goals or follow simple instructions, as judged by the investigators.

Where it's running

• VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA
  Pittsburgh, Pennsylvania, United States Recruiting

Study contacts

• Principal investigator: Michael A. Urbin, PhD — VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA
• Study coordinator: Michael A Urbin, PhD
• Email: Michael.Urbin@va.gov
• Phone: (412) 688-6000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.