Prism Adaptation Therapy for Stroke Rehabilitation
Official title: Prism Adaptation Treatment (PAT) for Right Brain Stroke Rehabilitation
Run by VA Office of Research and Development · NCT05983185 · Data updated 2026-11-12
This study is testing a new way to help Veterans with spatial neglect after a stroke by using brain scans to find out who would benefit most from a specific therapy that can improve their daily life.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 244 (estimated) |
| Sponsor | VA Office of Research and Development Federal |
| Locations | 4 sites (West Haven, Connecticut and 3 other locations) |
| Status | Recruiting |
| Started | February 1, 2023 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2027 |
| Registry record updated | April 23, 2026 |
| Trial ID | NCT05983185 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are Veterans who have experienced a first right brain stroke and are 1-4 months post-diagnosis.
✕Probably not a fit
Patients with chronic neurological disorders or those who have had a left brain stroke will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study focuses on improving rehabilitation for Veterans who experience spatial neglect after a right brain stroke. It aims to develop a brain scanning test that can objectively identify Veterans who are the best candidates for prism adaptation therapy (PAT), a treatment that has shown effectiveness in enhancing functional independence. The research will analyze neurobiological features to create a personalized approach to rehabilitation, addressing the significant treatment gap in cognitive rehabilitation for spatial neglect. By refining the referral process for PAT, the study seeks to improve daily life functions and overall quality of life for affected individuals.
Why it matters
Potential benefit: If successful, this approach could significantly enhance the independence and quality of life for Veterans suffering from spatial neglect after a stroke.
How similar studies have gone: Other studies have shown promise in using similar approaches for cognitive rehabilitation, but this specific biomarker-based method for identifying candidates for PAT is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Has had a first right brain stroke \>18 years of age * 1-4 months post-diagnosis of right brain stroke * Can sit up, see out of both eyes and point to objects (\>20/50 vision in both eyes) * Can give informed consent to participate Exclusion Criteria: * Has been diagnosed with other chronic, disabling neurological disorder (e.g. multiple sclerosis, Alzheimer Disease) * Has had a clinical left brain stroke or has neuroimaging evidence of prior stroke(s) including the presence of more than two lacunes with diameter greater than 15 mm. * Cannot sit up to be tested and receive PAT * Has \<20/50 vision when viewing with both eyes
Where it's running
-
VA Connecticut Healthcare System West Haven Campus, West Haven, CT
West Haven, Connecticut, United States Recruiting -
Atlanta VA Medical and Rehab Center, Decatur, GA
Decatur, Georgia, United States Recruiting -
VA Central Western Massachusetts Healthcare System, Leeds, MA
Leeds, Massachusetts, United States Recruiting -
Louis Stokes VA Medical Center, Cleveland, OH
Cleveland, Ohio, United States Recruiting
Study contacts
- Principal investigator: Anna M. Barrett, MD — VA Central Western Massachusetts Healthcare System, Leeds, MA
- Study coordinator: Akila Sanjay, BA
- Email: akila.sanjay@va.gov
- Phone: (508) 856-0104
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.