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Clinical trial Recruiting at 2 sites Interventional Ages 55 and up

Exercise and monitoring to improve muscle health in Veterans with chronic kidney disease

Official title: BCCMA: Recovery of Aged Muscle After Disuse Atrophy (REMEDY): Exercise and Monitoring With Post-Hospitalization Muscle Atrophy to Sustain Intrinsic Capacity and Strength (EMPHASIS)

Run by VA Office of Research and Development · NCT06607913 · Data updated 2026-11-12

This study is testing whether exercise and regular check-ins can help older Veterans with chronic kidney disease build strength and improve their overall health.

More Chronic Kidney Disease(CKD) trials

Quick facts

Study typeInterventional
Ages55 Years and up
SexAll
Enrollment250 (estimated)
SponsorVA Office of Research and Development
Federal
Locations2 sites (Aurora, Colorado and 1 other locations)
StatusRecruiting
StartedApril 11, 2025
Main results expectedSeptember 30, 2028
Study endsSeptember 30, 2029
Registry record updatedApril 7, 2026
Trial IDNCT06607913 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are Veterans aged over 55 with a diagnosis of Stage 3 or 4 chronic kidney disease.

Probably not a fit

Patients with poorly controlled cardiovascular conditions or contraindications to resistance training may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to address the issue of hospital-acquired weakness in older Veterans with chronic kidney disease (CKD) by implementing exercise and monitoring strategies. It will establish a baseline cohort of Veterans with Stage 3 and 4 CKD at two Veterans Affairs sites in Denver and Baltimore. The study will assess muscle health, including strength and mobility, and monitor participants over at least two years to evaluate the impact of home-based and supervised exercise on their physical resilience. The goal is to develop tailored interventions that can improve muscle health and overall well-being in this vulnerable population.

Why it matters

Potential benefit: If successful, this study could enhance muscle strength and resilience in Veterans with CKD, leading to improved recovery and quality of life.

How similar studies have gone: Other studies have shown success in using exercise interventions to improve muscle health in similar populations, indicating a promising approach.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Age \> 55 years
* Diagnosis of stage 3-4 CKD or an eGFR of \<45 mL/min/1.73m2

Exclusion Criteria:

* Cardiovascular risk: Poorly controlled hypertension (\>160/100)

  * Coronary event in past 6 months
  * Class III or IV CHF
  * symptomatic angina at rest or during exercise
  * Syncope in past year, without known resolution of cause
* COPD requiring home oxygen
* Contraindications to resistance training, including history of intracranial or retinal bleeding; Diabetes with active proliferative retinopathy
* History of significant spinal osteoarthritis or spinal stenosis
* Dementia (on medical record review or mini-mental status exam score)

Where it's running

  • Rocky Mountain Regional VA Medical Center, Aurora, CO
    Aurora, Colorado, United States     Recruiting
  • Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD
    Baltimore, Maryland, United States     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.