Exercise and monitoring to improve muscle health in Veterans with chronic kidney disease
BCCMA: Recovery of Aged Muscle After Disuse Atrophy (REMEDY): Exercise and Monitoring With Post-Hospitalization Muscle Atrophy to Sustain Intrinsic Capacity and Strength (EMPHASIS)
This study is testing whether exercise and regular check-ins can help older Veterans with chronic kidney disease build strength and improve their overall health.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 250 (estimated) |
| Ages | 55 Years and up |
| Sex | All |
| Sponsor | VA Office of Research and Development Federal |
| Locations | 2 sites (Aurora, Colorado and 1 other locations) |
| Trial ID | NCT06607913 on ClinicalTrials.gov |
What this trial studies
This study aims to address the issue of hospital-acquired weakness in older Veterans with chronic kidney disease (CKD) by implementing exercise and monitoring strategies. It will establish a baseline cohort of Veterans with Stage 3 and 4 CKD at two Veterans Affairs sites in Denver and Baltimore. The study will assess muscle health, including strength and mobility, and monitor participants over at least two years to evaluate the impact of home-based and supervised exercise on their physical resilience. The goal is to develop tailored interventions that can improve muscle health and overall well-being in this vulnerable population.
Who should consider this trial
Good fit: Ideal candidates for this study are Veterans aged over 55 with a diagnosis of Stage 3 or 4 chronic kidney disease.
Not a fit: Patients with poorly controlled cardiovascular conditions or contraindications to resistance training may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance muscle strength and resilience in Veterans with CKD, leading to improved recovery and quality of life.
How similar studies have performed: Other studies have shown success in using exercise interventions to improve muscle health in similar populations, indicating a promising approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \> 55 years * Diagnosis of stage 3-4 CKD or an eGFR of \<45 mL/min/1.73m2 Exclusion Criteria: * Cardiovascular risk: Poorly controlled hypertension (\>160/100) * Coronary event in past 6 months * Class III or IV CHF * symptomatic angina at rest or during exercise * Syncope in past year, without known resolution of cause * COPD requiring home oxygen * Contraindications to resistance training, including history of intracranial or retinal bleeding; Diabetes with active proliferative retinopathy * History of significant spinal osteoarthritis or spinal stenosis * Dementia (on medical record review or mini-mental status exam score)
Where this trial is running
Aurora, Colorado and 1 other locations
- Rocky Mountain Regional VA Medical Center, Aurora, CO — Aurora, Colorado, United States (Recruiting)
- Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD — Baltimore, Maryland, United States (Recruiting)
Study contacts
- Principal investigator: Michael Harris-Love, DSc MPT BS — Rocky Mountain Regional VA Medical Center, Aurora, CO
- Study coordinator: Michael Harris-Love, DSc MPT BS
- Email: MICHAEL.HARRIS-LOVE@CUANSCHUTZ.EDU
- Phone: (720) 857-2802
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.