Using topical imipramine with photodynamic therapy for skin lesions in veterans

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effects of topical imipramine when used alongside photodynamic therapy (PDT) to treat actinic keratosis in veterans. PDT is a standard treatment for precancerous skin lesions, and this research aims to determine if imipramine can mitigate the immunosuppressive effects of PDT, potentially enhancing its efficacy. Participants will be recruited from the Dayton VA Medical Center, where they will receive both treatments under careful monitoring. The study focuses on adult patients with fair skin types who have been prescribed PDT for their skin conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult Males and Females ages 18 and older who are patients at the Dayton VAMC Dermatology clinics
* Skin type must be "Fair", Fitzpatrick type I or II, due to the presence of actinic damage in this population.
* Subjects must have a VA physician's order to receive PDT treatment on their forearms.
* Willing to participate and understand the informed consent document.
* Willing to avoid excess sun exposure/tanning beds to the area to be treated with PDT.
* Has stable transportation to attend study visits at DVA

Exclusion Criteria:

* Currently taking any tricyclic antidepressants (TCAs)
* Currently taking any selective serotonin reuptake inhibitor (SSRI)
* Has Porphyria
* Large tattoos in areas to be tested
* Pregnancy or nursing
* Taking any oral or topical medications that could interfere with the PDT
* Active rashes in the areas

Where it's running

• Dayton VA Medical Center, Dayton, OH
  Dayton, Ohio, United States Recruiting

Study contacts

• Principal investigator: Jeffrey Travers, MD — Dayton VA Medical Center, Dayton, OH
• Study coordinator: Craig A Rohan, MD
• Email: craig.rohan@va.gov
• Phone: (937) 245-7500

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.