Internet-based depression intervention for veterans
Official title: A Randomized Controlled Trial of Deprexis; Evaluation of A Computerized Intervention to Decrease Depression and Restore Functioning in Veterans
Run by VA Office of Research and Development · NCT06217198 · Data updated 2026-11-12
This study tests whether an online program called Deprexis can help veterans with mild to moderate depression feel better compared to standard treatment.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 152 (estimated) |
| Sponsor | VA Office of Research and Development Federal |
| Locations | 1 site (Waco, Texas) |
| Status | Recruiting |
| Started | May 1, 2024 |
| Main results expected | April 30, 2029 |
| Study ends | April 30, 2029 |
| Registry record updated | August 10, 2026 |
| Trial ID | NCT06217198 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are male and female veterans with mild to moderate depressive symptoms who have reliable internet access.
✕Probably not a fit
Patients with severe depression, psychotic disorders, or current suicidal risk may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This project focuses on addressing depressive symptoms among veterans through a self-guided internet intervention called Deprexis. The intervention aims to improve mental health outcomes and functional impairments associated with depression by providing a remote and accessible treatment option. The study will involve interviews to understand veterans' perceptions and preferences regarding Deprexis, followed by a randomized controlled trial comparing Deprexis to standard treatment. The goal is to evaluate the acceptability and effectiveness of this intervention for veterans experiencing mild to moderate depression.
Why it matters
Potential benefit: If successful, this intervention could significantly improve the mental health and quality of life for veterans suffering from depression.
How similar studies have gone: Other studies have shown promise in using internet-based interventions for mental health, suggesting potential success for this approach in veterans.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Potential participants include male and female Veterans of all races/ethnicities who are: * able to comprehend and sign the informed consent form * have reliable access to the internet and a computer, tablet and/or smartphone * exhibit mild or moderate, but not very severe, levels of depression * stable on psychotropic medications Exclusion Criteria: Aim 1 and Aim 2: Veterans will be excluded from study participation if they: * endorse any positive symptoms of a psychotic disorder * screen positive for Bipolar I Disorder * report current suicidal risk
Where it's running
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Central Texas Veterans Health Care System Waco VA Medical Center, Waco, TX
Waco, Texas, United States Recruiting
Study contacts
- Principal investigator: Rahel R Pearson, PhD — Central Texas Veterans Health Care System Waco VA Medical Center, Waco, TX
- Study coordinator: Rahel R Pearson, PhD
- Email: rahel.pearson@va.gov
- Phone: (254) 297-5155
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.