Repetitive Transcranial Magnetic Stimulation for Stimulant Use Disorder in Veterans

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial tests repetitive transcranial magnetic stimulation (rTMS) as a somatic treatment for veterans with severe stimulant use disorder. Participants receive either active rTMS or sham treatment in a controlled setting, with biomarker analysis to help predict who may respond. The study aims to identify biological indicators that guide patient selection and forecast treatment response. Eligibility is limited to U.S. veterans with DSM-confirmed stimulant use disorder and stable health, with specific exclusions to minimize seizure risk. Conducted at VA Palo Alto and Stanford University settings, led by the VA Office of Research and Development.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Must be a U.S. Veteran
* Structured Clinical Interview for DSM Disorders (SCID) confirmed diagnosis of SUD, severe
* Last use of stimulants \>2 and \<8 weeks
* Stable medication regimen (no change in dose or agents between 2 weeks prior to the start of and throughout the treatment phase of the study)
* Stable medical health

Exclusion Criteria:

* Pregnant or lactating female
* History of prior adverse reaction to Transcranial magnetic stimulation (TMS)
* On medications thought to significantly lower seizure threshold, e.g. clozapine, chlorpromazine, clomipramine, and bupropion \> 400mg/day
* Seizure disorder or conditions known to substantially increase risk for seizures
* Implants or medical devices incompatible with TMS
* Acute or unstable chronic medical illness that would affect participation or compliance in the study, e.g. unstable angina
* Unstable psychiatric symptoms that precludes consistent participation in the study, e.g. active current suicidal intent or plan; severe psychosis
* Other substance use disorder not in remission
* Chronic or recurring Axis I psychotic disorders
* For subjects participating in functional magnetic resonance imaging (fMRI) scans, presence of ferromagnetic material in their body or taking DAergic medications

Where it's running

• VA Palo Alto Health Care System, Palo Alto, CA
  Palo Alto, California, United States Recruiting

Study contacts

• Principal investigator: Jong H. Yoon, MD — VA Palo Alto Health Care System, Palo Alto, CA
• Study coordinator: Jong H Yoon, MD
• Email: Jong.Yoon@va.gov
• Phone: (650) 493-5000

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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  This study tests if a new combined care approach for patients with infections from using opioids or stimulants can help them stay healthier and avoid going back to the hospital compared to regular treatment.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.