Clinical trial Recruiting at 1 site Interventional Ages 18 and up

MOVED: a web-based mood-elevating program for Veterans with PTSD

Official title: A Randomized Controlled Trial of a Web-Based Moral Elevation Intervention for Veterans With PTSD

Run by VA Office of Research and Development · NCT06788678 · Data updated 2026-11-12

This study tests MOVED, a web-based, self-guided program to see if it can reduce PTSD symptoms and improve social functioning and quality of life for Veterans compared with a neutral, supportive control.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment250 (estimated)
SponsorVA Office of Research and Development
Federal
Locations1 site (Temple, Texas)
StatusRecruiting
StartedAugust 10, 2026
Main results expectedJune 30, 2029
Study endsSeptember 30, 2029
Registry record updatedAugust 19, 2026
Trial IDNCT06788678 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Veterans with a current PTSD diagnosis (CAPS-5) who are English-speaking, have internet access, are enrolled in VISN 17, and are not currently receiving trauma-focused therapy or meeting exclusion criteria.

Probably not a fit

Patients with severe traumatic brain injury, active psychosis or mania, current suicide risk, or those undergoing active trauma-focused treatment may not benefit from MOVED.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized trial evaluates MOVED, a self-guided web-based intervention designed to elicit moral elevation in Veterans with PTSD. The study compares MOVED to a generic supportive control over 4 weeks (8 sessions) to see if it reduces PTSD symptoms and improves social functioning and quality of life. Participants must have PTSD, be English-speaking, and have internet access, with enrollment limited to those in the VISN 17 system and without certain comorbid conditions or ongoing trauma-focused therapies. The primary care setting is a VA health system site in Temple, Texas, targeting feasible, scalable, stand-alone treatment options. Outcomes include PTSD symptom change and broader psychosocial functioning.

Why it matters

Potential benefit: If successful, MOVED could offer an accessible, stand-alone option to help Veterans with PTSD improve symptoms, social functioning, and quality of life.

How similar studies have gone: Prior pilot work in Veterans suggested the MOVED approach is feasible and acceptable, supporting further testing in a larger randomized trial.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Enrolled in a VISN 17 health care system
* English-speaking and able to provide written informed consent
* Willingness to complete study procedures and be randomized
* Internet access and an electronic device to complete the web-based sessions
* Current diagnosis of PTSD based on the CAPS-5
* History of PTSD diagnosis for at least 1 year

Exclusion Criteria:

* History of severe traumatic brain injury indicated by medical record review and the Ohio State Traumatic Brain Injury Identification Method (OSU TBI-ID)
* Current psychosis or mania as indicated by medical record review and the Mini International Neuropsychiatric Interview (MINI)
* Current suicide risk based on the Beck Depression Inventory-II (BDI-II)
* Currently enrolled and actively participating in a trauma-focused treatment including:

  * Cognitive Processing Therapy
  * Prolonged Exposure
  * Eye Movement Desensitization Reprocessing

Where it's running

  • Central Texas Veterans Health Care System, Temple, TX
    Temple, Texas, United States
    Recruiting

Study contacts

  • Principal investigator: Adam P. McGuire, PhD — Central Texas Veterans Health Care System, Temple, TX
  • Study coordinator: Adam P McGuire, PhD
  • Email: Adam.McGuire@va.gov
  • Phone: (254) 297-5173

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.