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Clinical trials and research at University Medical Center Groningen
As of November 12, 2026, Find a Trial lists 94 clinical trials run by University Medical Center Groningen that are recruiting, at sites in 14 countries (most in Netherlands (94), France (4), Belgium (3)). 1 was first registered in the last 30 days. By phase: Phase 2 (10), Phase 4 (5), Phase 1 (5), Phase 1/2 (4). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 94Clinical trials
- 1New in 30 days
- 14Countries
Newest trials
All recruiting trials (94)
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Can FAPI or FDG PET/CT help diagnose active Peyronie's disease
This study tests whether FAPI-PET/CT or FDG-PET/CT scans can detect active inflammation or fibroblast activity in men with Peyronie’s disease.
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PEM: a starting point to understand ME/CFS
Researchers are studying post-exertional malaise to better understand ME/CFS in adults who report persistent fatigue and PEM.
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Isoniazid inhalation in TB patients: a first-in-human look at local tolerability and body levels
This early study tests inhaled isoniazid to see how well it tolerates the lungs and how it behaves in the body in adults with tuberculosis.
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Neoadjuvant nivolumab for cervical cancer using tumor-draining lymph nodes
This study tests different doses of nivolumab injected near the tumor to see if the treatment is safe and feasible before standard surgery in newly diagnosed cervical cancer.
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Pembrolizumab Registry for Outcomes and Treatment Evaluation in Cervical Cancer
This registry follows people with persistent, recurrent, or metastatic cervical cancer who are treated with pembrolizumab-containing regimens to see how well it works in real-world care.
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No Guts No Glory Probiotics: Can probiotics help with antipsychotic side effects?
This study tests whether a probiotic supplement can help prevent weight gain, high blood sugar, and bad cholesterol in adults starting or already on antipsychotic medications.
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Reference framework for outcomes after machine-preserved liver transplantation in Europe
This study tests how liver transplants that use machine perfusion perform in real-world practice, to see how different perfusion methods relate to outcomes for adults in Europe.
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Support program for internationally trained nurses starting work in the Netherlands
This project will see if a fast-track language and integration program helps refugee and migrant nurses start nursing jobs in the Netherlands.
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LEEF shoe for reducing plantar pressure and improving acceptance in people with diabetic neuropathy
This trial tests whether the LEEF shoe reduces pressure on the soles and is easier to wear for adults with diabetes-related neuropathy than standard custom orthopaedic shoes.
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Virtual reality schema therapy exercises with parent and child modes
This study tests whether virtual-reality dialogue exercises using parent and child avatars are feasible and helpful for adults (18–65) with psychiatric symptoms linked to early-life experiences.
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Early Intervention for Adults with Ongoing Post-Concussion Symptoms after Mild TBI
This study tests a package of physical/occupational therapy and telephonic psychoeducation to help adults recover after a mild traumatic brain injury.
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Vicadrostat versus spironolactone: effects on kidney function and protein markers
This will test whether vicadrostat or spironolactone, each given with empagliflozin, changes kidney function and blood/urine protein patterns in adults with CKD and heart disease or heart failure.
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Long-term health of children born to mothers who had a solid organ transplant
This project will look for long-term heart, kidney, and immune system problems in people aged 16 and older who were born to mothers who had a kidney, liver, pancreas, heart, or lung transplant.
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Bypass surgery versus stents for people with weak heart pumping and blockages in multiple coronary arteries
This trial tests whether bypass surgery (CABG) or stents (PCI) lead to better survival, fewer major heart problems, and improved quality of life for adults with reduced left ventricular function (LVEF ≤40%) and multivessel coronary disease.
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TASTY training to improve taste and smell for people taking tyrosine kinase inhibitors
This trial tests whether a 12-week at-home taste and smell training program helps adults who developed taste changes after starting tyrosine kinase inhibitor treatment.
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TASTY taste-steering for chemotherapy-related taste changes
This trial tests whether an at-home 'taste steering' program helps adults on chemotherapy for metastatic triple-negative breast cancer, metastatic testicular cancer, or stage II–IV diffuse large B cell lymphoma enjoy food more.
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Adding high-fiber dried chicory root after surgery for intermediate- to high-risk cutaneous melanoma.
Try whether taking a daily high-fiber dried chicory root supplement (WholeFiber) for six weeks changes gut short-chain fatty acids, gut microbes, and immune cells in people who have had surgery for intermediate- to high-risk stage II cutaneous melanoma.
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Virtual Reality chairwork for schema therapy in healthy volunteers
This study tests whether using a Virtual Reality chairwork exercise can make schema therapy imagery easier and more impactful for healthy participants who have unmet childhood needs.
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Indocyanine green to highlight tumor depth and margins during endoscopic removal of esophageal or stomach cancer
This trial will test whether a dye called indocyanine green can help doctors see the depth and edges of superficial esophageal or stomach cancers during endoscopic submucosal dissection.
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Targeted radiotherapy to up to three growing prostate cancer spots in castration‑resistant disease
This trial will try adding targeted radiotherapy to up to three progressing spots to see if it can delay the next systemic treatment and extend disease control in men with oligoprogressive castration‑resistant prostate cancer.
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Personalized IV fluid care for sepsis in the emergency department
This study will test whether giving IV fluids based on each adult's heart response helps people with suspected sepsis in the emergency department recover more safely than standard fluid care.
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SSTR2 PET/CT imaging with 68Ga-DOTA-TOC for nasopharyngeal cancer
We will test whether 68Ga‑DOTA‑TOC PET/CT scans can detect SSTR2 in adults with EBV‑positive nasopharyngeal cancer before and three weeks after starting chemotherapy or chemoradiotherapy.
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Telemedicine follow-up for early laryngeal cancer patients
This study tests if follow-up care through Telemedicine is just as good as in-person visits for people with early laryngeal cancer, especially for those who live far from treatment centers.
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Respiratory Muscle Health in End-Stage COPD on the Transplant Path
This study tests how respiratory muscles behave in people with severe COPD who are on the lung transplant waiting list, and whether noninvasive ventilation and muscle changes influence recovery after transplant.
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Psilocybin therapy for depression and existential distress in people with COPD, ALS, MS, or atypical Parkinson disease
This trial will test whether psilocybin therapy can reduce depression and psychological distress in adults with COPD, ALS, MS, or atypical Parkinson disease who have at least six months expected life.
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Observational analysis of Progressive Familial Intrahepatic Cholestasis treatment
This study is looking at how different treatments for Progressive Familial Intrahepatic Cholestasis work and what happens to patients over time to help improve care for those with this rare liver disease.
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Hinting Task to measure social thinking in Huntington's disease
This research will test whether the Hinting Task can reliably measure Theory of Mind (social thinking) in Dutch-speaking adults with Huntington's disease.
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EMDR therapy for chemotherapy-induced conditioned nausea and vomiting in cancer survivors
This study will try EMDR therapy to reduce chemotherapy-related conditioned nausea and vomiting in people who previously had cancer.
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Evaluating a diagnostic strategy for acute appendicitis in children with abdominal pain
This study is testing a new way for doctors to figure out if kids with belly pain have appendicitis to see if it helps reduce unnecessary trips to the hospital while still catching any serious cases.
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Using routine clinical data to improve rehabilitation for people with disabilities and chronic diseases
This study looks at using regular health data from patients with disabilities and chronic diseases to see how rehabilitation treatments can be improved and personalized for better care.
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How endobronchial valves change oxygen use during everyday activities
This will see if endobronchial valve treatment helps people with severe emphysema use less oxygen and feel less breathless when doing daily tasks.
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Virtual reality assessment for asylum seekers with paranoid delusions
This study tests whether virtual reality can help understand the thoughts and feelings of asylum seekers with paranoid delusions to improve their treatment.
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Subtyping Primary Aldosteronism With Para-chloro-2-[18F]Fluoroethyl-etomidate
This study is trying to see if a special imaging technique can help doctors better understand different types of primary aldosteronism in patients.
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Fluorescence imaging of a drug for inflammatory bowel disease
This study is testing a special version of a drug for inflammatory bowel disease to see how well it targets the right areas in the body and to find the best dose for patients.
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At-home monitoring for patients undergoing chemoradiation for head and neck cancer
This study is testing whether at-home monitoring can help patients with head and neck cancer manage their treatment better during and after chemoradiation.
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Congestion profiles in adults hospitalized with acute heart failure
This project will see if different congestion types in adults hospitalized with acute heart failure predict response to IV loop diuretics and risks of rehospitalization or death.
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Imaging of immune response in advanced solid tumors
This study is testing a new imaging method to see how well it can track the immune response in people with advanced solid tumors who are receiving PD-1 antibody treatments.
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Evaluation of follow-up care for patients with brain cancer
This study is trying to see how well follow-up care works for brain cancer patients after they receive radiation treatment, to help improve their outcomes and future therapies.
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Effect of cannabis oil on untreatable liver cancer
This study tests whether cannabis oil can help people with untreatable liver cancer feel better by seeing if it affects their tumors.
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Carotid artery stenting during treatment of acute stroke
This study is testing if adding carotid artery stenting during a stroke treatment can help improve blood flow to the brain and lower the chances of having another stroke for patients with blocked carotid arteries.
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Validation of a Dutch version of the Prosthesis Evaluation Questionnaire
This study is testing a Dutch version of a questionnaire to see how well it helps adults with lower limb prostheses share their experiences and needs.
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Higher-dose proton radiation for stage III non-small-cell lung cancer
This pilot tests whether giving a higher dose of proton radiation together with chemo and planned immunotherapy is safe and tolerable for adults with stage III non-small-cell lung cancer.
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Image-guided proton therapy for advanced head and neck cancer
This study is testing a new way to use proton therapy combined with chemotherapy to see if it can safely deliver a higher dose to treat advanced head and neck cancer while protecting healthy tissue.
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Developing models to predict complications after treatment for esophageal cancer
This study is trying to create tools that can predict complications after treatment for esophageal cancer to help doctors choose the best care for their patients.
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Investigating the Role of Nasal Microbiome in Eosinophilic Granulomatosis with Polyangiitis
This study is trying to see how the bacteria in the nose affect the immune system in people with Eosinophilic Granulomatosis with Polyangiitis and related conditions, and whether a new treatment can change that.
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Using patiromer to improve blood pressure treatment in chronic kidney disease
This study is testing if a medication called patiromer can help improve blood pressure treatment for people with chronic kidney disease by making another medication work better.
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Investigating ventilation practices in critically ill children
This study looks at how doctors are using breathing machines for critically ill children in hospitals to see if different practices can improve their recovery and survival rates.
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Comparing AF ablation and medication for treating atrial fibrillation in patients with atrial cardiomyopathy
This study is testing whether a procedure called AF ablation works better than medication for treating atrial fibrillation in older patients with a specific heart condition.
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Comparing pulsed field ablation and radiofrequency ablation for repeat treatment of atrial fibrillation
This study is testing whether a new type of heart procedure called pulsed field ablation works better than the traditional method, radiofrequency ablation, for people with recurring atrial fibrillation who need another treatment.
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Understanding how mindfulness and positive fantasizing can help reduce depression vulnerability
This study is testing if mindfulness and positive fantasizing can help people who have recovered from depression avoid falling back into it.
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Evaluating ctDNA diagnostics for Stage III lung cancer
This study is testing how well blood tests that check for tumor DNA can help people with Stage III lung cancer during and after their treatment.
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Evaluating the effects of bariatric surgery on heart failure and atrial fibrillation
This study is testing if bariatric surgery can improve heart health and quality of life for obese patients who have heart failure and atrial fibrillation compared to standard care.
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Examining muscle function changes before and after endobronchial valve treatment for emphysema
This study is testing how a specific lung treatment for severe emphysema affects muscle function in patients to see if it helps them feel better and move more easily.
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Understanding cognitive and emotional profiles in Multiple Sclerosis
This study is trying to understand how thinking and feeling differently affects the daily lives of people with Multiple Sclerosis to help improve their care.
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Virtual reality therapy for people hearing voices
This study is testing a new virtual reality therapy to see if it can help people who hear distressing voices feel better and gain control over their experiences.
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Using a device to help manage breathlessness in COPD patients
This study tests if a hands-free device can help people with COPD breathe easier during activities and improve their overall quality of life.
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Screening MRI for brain disease in advanced lung cancer patients
This study tests whether MRI scans of the brain can help find hidden brain cancer in patients with advanced lung cancer who don’t have any symptoms.
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Long-term effects of breast cancer treatment on heart function
This study looks at how breast cancer treatments affect heart health in women who survived breast cancer to see if any heart problems they had in the past might get worse over time.
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Warm machine perfusion for older deceased-donor kidneys before transplant
This study will test whether giving kidneys from deceased donors aged 50 or older six hours of warm machine perfusion before transplant improves kidney function at 12 months for adults getting their first or second kidney transplant.
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Improving home ventilation for chronic respiratory failure patients
This study is testing a new way to monitor patients with chronic respiratory failure who use home ventilation to see if it improves their breathing comfort and effectiveness.
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Oral bevacizumab-800CW and cetuximab-800CW to detect early esophageal adenocarcinoma
This trial tests whether drinking two fluorescent tracers before an endoscopy helps doctors find early esophageal adenocarcinoma in people with Barrett's esophagus or suspected dysplasia.
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Investigating how ustekinumab distributes in inflamed tissues for Crohn's disease and psoriasis
This study is testing how well the drug ustekinumab works in people with Crohn's disease and psoriasis who haven't found relief from other treatments by looking at where the drug goes in their inflamed tissues.
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Assessing long-term outcomes of donor livers preserved with machine perfusion
This study looks at whether using a special machine to keep donor livers healthy for longer before transplant can help people have better long-term outcomes after their liver surgery.
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Iodine uptake in thyroid cancer patients after a low iodine diet
This study is testing whether a low iodine diet for 7 days can help improve how well radioactive iodine is taken up by the thyroid in patients with thyroid cancer who are getting ready for treatment.
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Comparing different techniques for lumbar spine surgery
This study is testing if a new way of doing back surgery can help people feel less pain after surgery compared to traditional methods.
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Comparing standard and adjusted doses of alectinib for lung cancer treatment
This study is testing if adjusting the dose of alectinib based on blood levels can help people with ALK positive lung cancer live longer without their disease getting worse compared to the standard dose.
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Measuring free radicals in human sperm related to lifestyle and microbiota
This study is testing how free radicals in sperm might affect male infertility by looking at their levels in relation to lifestyle and gut bacteria.
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Combination therapy with atezolizumab and tiragolumab for solid tumors
This study is testing a new combination treatment using two immune-boosting drugs for people with solid tumors, like melanoma and head and neck cancers, to see if it can help them fight their cancer better than current treatments.
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Assessing risk factors in heart failure with preserved ejection fraction
This study is trying to find out what factors can predict hospital visits and death in people with heart failure who still have a good heart function.
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Using a GnRH Agonist to Treat Severe Polycystic Liver Disease in Women
This study is testing if a medication called leuprorelin can help reduce liver size in women with severe polycystic liver disease who are still experiencing growth despite other treatments.
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Improving detection of lung nodules using advanced imaging technology
This study is testing a new type of imaging technology to see if it can better detect small lung nodules in patients and help doctors figure out if they are cancerous or not.
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Using virtual reality to help manage stress and sleep issues
This study is testing if a virtual reality app can help people with mental health issues feel less stressed and sleep better.
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Hydrochlorothiazide added to tolvaptan to protect kidneys and improve quality of life in ADPKD
This trial tests whether adding low-dose hydrochlorothiazide to adults with ADPKD who are already taking tolaptan slows kidney decline and reduces side effects like excessive urination.
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Chemoradiation for vulvar cancer patients with large sentinel node metastasis
This study is testing if combining chemotherapy and radiation can be a safer and more effective treatment for women with early-stage vulvar cancer who have larger cancer spread in their lymph nodes, instead of having surgery.
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Investigating early ageing in young cancer patients during treatment
This study is trying to see how cancer treatment affects early aging and heart health in young adults aged 18-39 who are undergoing therapy for cancer.
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Comparing surgery and mechanical ventilation for diaphragm paralysis
This study is testing whether surgery or a breathing machine works better for adults with diaphragm paralysis caused by nerve injury.
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Using CPAP or BiPAP to reduce tumor movement during radiotherapy
This study is testing if using CPAP or BiPAP can help control breathing and reduce tumor movement during radiation treatment for patients with lung tumors.
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Radiotherapy for recurrent prostate cancer using PSMA-PET guidance
This study is testing a new type of radiation therapy for men with recurring prostate cancer to see if it works better than the standard treatment.
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A large biobank for acute and emergency medicine
This study is collecting health information and samples from patients with sudden illnesses in the Emergency Department to see if it can help improve treatments and predict how patients will do.
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Transplanting stem cells from the submandibular gland to treat head and neck cancer
This study is testing if transplanting stem cells from the salivary glands can help people with head and neck cancer recover their saliva production and improve their quality of life after treatment.
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Heterogeneity of Critical Illness in ICU Patients
This study tests how patient characteristics relate to the severity of organ failure in adults admitted to the ICU with critical illness.
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Investigation of lung valves in patients with emphysema or COPD
This study is trying to understand how certain biological responses in patients with severe COPD affect the success of a treatment using lung valves to help improve their breathing.
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Impact of chemotherapy on early ageing in testicular cancer patients
This study tests how chemotherapy for testicular cancer affects aging in patients by looking at changes in their skin and fat cells.
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Investigating heart and lung effects of radiotherapy in cancer patients
This study is trying to see if radiation treatment for esophageal cancer and lung cancer can cause high blood pressure in the lungs and how it affects patients' hearts and lungs.
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Examining gut microbiome changes in advanced colorectal cancer during chemotherapy
This study looks at how chemotherapy changes the gut bacteria in people with advanced colorectal cancer to see if understanding these changes can help improve treatment outcomes.
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Fluorescence imaging with labeled adalimumab to map inflammation in IBD and rheumatoid arthritis
This trial will test whether a fluorescent version of adalimumab can highlight inflamed bowel tissue or hand joints in adults with active IBD or rheumatoid arthritis.
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Nasal high-flow therapy for COPD exacerbations
This study is testing if nasal high-flow therapy can help hospitalized patients with COPD recover better from flare-ups compared to standard care.
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Understanding toxicity in prostate cancer treatment
This study looks at how treatment for prostate cancer affects patients' side effects and quality of life over time.
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National database for bronchoscopic treatment of emphysema in the Netherlands
This study is creating a national database to track how well new bronchoscopic treatments work for people with severe emphysema in the Netherlands over five years.
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Evaluation of complications from radiation treatment for cervical cancer
This study is looking at the side effects and recovery experiences of women with cervical cancer who are receiving radiation treatment to see how it affects them over time.
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Implantation of an Auditory Brainstem Implant for Unilateral Tinnitus Treatment
This study is testing whether an auditory brainstem implant can help people with severe ringing in one ear feel better by reducing their tinnitus symptoms.
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Follow-up program for patients with esophageal cancer
This study is trying to create a follow-up program for people with esophageal cancer to see how well treatments work and how they affect quality of life, so doctors can make better treatment choices in the future.
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Follow-up program for patients with head and neck cancer
This study is testing a new follow-up program for people with head and neck cancer to see if it can reduce side effects from radiation while still being effective in treating their cancer.
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Follow-up program for lung cancer patients treated with radiation
This study is trying to create a follow-up program for lung cancer patients who had radiation treatment to see how well they are doing and to gather information that could help improve future treatments.
Quick answers
How many clinical trials run by University Medical Center Groningen are recruiting right now?
94, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 14 countries. The most sites are in Netherlands (94 trials), France (4 trials), Belgium (3 trials), Germany (3 trials), Spain (3 trials). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 10, Phase 4: 5, Phase 1: 5, Phase 1/2: 4. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.