Heterogeneity of Critical Illness in ICU Patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective observational cohort study of adult critically ill patients admitted to the ICU. The researchers will examine how baseline characteristics relate to how severely organs fail during the ICU stay, using the maximum SOFA score as the primary measure and quality of life at one year as a follow-up endpoint. Data collection aligns with standard ICU care, with optional additional exams and a blood sample obtained during admission; follow-up includes phone assessments at 6 months and home visits at 12 months. No new treatments are tested or assigned; the study observes real-world practice to identify patterns and potential causal pathways behind divergent outcomes. IRB-approved procedures ensure patient safety and privacy, and informed consent is required.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults Definition: age ≥18 years.
* Emergency admission to the ICU Definition: patients who are acutely admitted to the ICU due to acute or unexpected critical illness, either from the emergency department or the ward or transferred from an ICU (or a ward) from another hospital.

Exclusion Criteria:

* Planned admission
* Absence of an invasive arterial or venous line for blood sampling.
* Any continued cardiopulmonary resuscitation efforts upon admission which limit access to the patient for research activities.
* Main ICU admission reason chronic (non-invasive) home ventilation
* Main ICU admission reason normothermic treatment after cardiac arrest
* Main ICU admission reason ischemic stroke, intracerebral bleeding, or isolated neurotrauma
* Main ICU admission reason Coronavirus Disease 2019 (COVID-19)
* Solid organ or hematopoietic stem cell transplant during current hospital admission
* Strict isolation due to any contagious disease
* No informed consent

Where it's running

• University Medical Center Groningen
  Groningen, Provincie Groningen, Netherlands Recruiting

Study contacts

• Principal investigator: Frederik Keus, PhD — University Medical Center Groningen
• Study coordinator: Fredrike Zwiers, PhD
• Email: f.zwiers-blokzijl@umcg.nl
• Phone: +31 503619838

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Transducer levelling errors in everyday ICU practice

  In critically ill, vasopressor-treated adults with arterial and central venous lines, this study tests how small height differences in pressure transducers may lead to measurement errors that could affect treatment decisions.

  Recruiting Vastra Gotaland Region · Gothenburg and 1 other locations · NCT07330505

• What predicts death in the ICU? Analyzing APACHE II in Colombian patients

  This study tests how well the APACHE II score predicts ICU mortality in adults treated at a Colombian hospital.

  Recruiting Hospital Departamental de Villavicencio · Villavicencio, Meta Department · NCT07249749

• Sivelestat treatment to protect organs after surgery for type A aortic dissection

  In this multicenter trial, patients after surgery for type A aortic dissection receive sivelestat or a placebo to see if it helps protect organ function.

  Recruiting Phase 4 Shanghai Zhongshan Hospital · Hefei, Anhui and 6 other locations · NCT07156656

• Using parasternal intercostal muscle thickening to help decide when to stop mechanical ventilation

  This trial will test whether adding a bedside ultrasound measurement of parasternal intercostal muscle thickening helps doctors decide when to take critically ill patients off mechanical ventilation to reduce reintubation.

  Recruiting Cairo University · Cairo, Giza Governorate · NCT07143695

• Beacons for ICU: extra clinician alerts in ICU sub-units

  This study tests whether adding the ICU Beacon clinician awareness system to standard ICU care improves outcomes for adults with respiratory or circulatory failure compared with standard care alone.

  Recruiting ETH Zurich · Bern · NCT07119411

• Electronic archive for treating severe organ failure and liver transplantation

  This study looks at medical records of patients with severe liver failure to see how well different treatments work and improve liver transplant care over the next 10 years.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, Bologna · NCT06781502

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.