Examining muscle function changes before and after endobronchial valve treatment for emphysema

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the physiological and structural adaptations of peripheral muscle function at a cellular level in patients with severe emphysema who are scheduled for bronchoscopic lung volume reduction treatment using one-way endobronchial valves. The study employs a single-arm pretest-posttest design, utilizing 31P-Magnetic Resonance Spectroscopy to assess muscle function before and after the intervention. By understanding these adaptations, the study seeks to provide insights into the broader impacts of EBV treatment on exercise capacity and quality of life for patients with chronic obstructive pulmonary disease (COPD).

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient is scheduled for a bronchoscopic lung volume treatment using one-way endobronchial valves;
* Patient read, understood and signed the Informed Consent Form.

Exclusion Criteria:

* Inability to perform a cycle ergometry test;
* Contraindications for undergoing a magnetic resonance imaging scan (e.g. claustrophobia, implanted cardiac devices);
* Body length \>190cm;
* Any anticoagulant therapy;
* COPD exacerbation 4 weeks prior to testing.

Where it's running

• Univeristy Medical Center Groningen
  Groningen, Netherlands Recruiting

Study contacts

• Principal investigator: Dirk-Jan Slebos, MD PhD — UMC Groningen
• Study coordinator: Else ter Haar, MD
• Email: e.a.m.d.ter.haar@umcg.nl
• Phone: +31503619194

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.