Improving detection of lung nodules using advanced imaging technology
Official title: Ultra-long Field-Of-View Positron Emission Tomography for Characterization of Indeterminate Lung Nodules: a Pilot Study Exploring Opportunities for Clinical Research
Run by University Medical Center Groningen · NCT05463913 · Data updated 2026-11-12
This study is testing a new type of imaging technology to see if it can better detect small lung nodules in patients and help doctors figure out if they are cancerous or not.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 100 Years |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | University Medical Center Groningen Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Groningen) |
| Status | Recruiting |
| Started | July 13, 2022 |
| Main results expected | June 1, 2025 |
| Study ends | June 1, 2025 |
| Registry record updated | March 7, 2025 |
| Trial ID | NCT05463913 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients with confirmed indeterminate lung nodules of 6-15 mm who are scheduled for biopsy or resection.
✕Probably not a fit
Patients with claustrophobia, those who are pregnant or breastfeeding, or individuals with uncontrolled diabetes may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effectiveness of ultra-long Field-Of-View PET/CT scanners in detecting indeterminate lung nodules sized 6-15 mm, which are commonly found in patients undergoing chest CT scans. The research aims to enhance early detection and diagnosis of lung cancer by assessing the sensitivity and image quality of this new imaging technology compared to traditional methods. Participants will undergo routine 18F-FDG PET/CT imaging as part of their clinical care, and the study will evaluate the technical performance of this approach in differentiating malignant from benign nodules. The goal is to improve follow-up procedures and reduce the need for repeated CT scans, thereby minimizing radiation exposure and patient anxiety.
Why it matters
Potential benefit: If successful, this study could lead to earlier and more accurate detection of lung cancer, improving patient outcomes.
How similar studies have gone: While there have been advancements in imaging technologies, this specific approach using ultra-long FOV PET/CT is novel and has not been extensively tested in prior studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * able to give informed consent * signed informed consent * confirmed indeterminate lung nodule(s) of 6-15 mm in size on CT chest imaging * routine 18F-FDG PET/CT performed * scheduled for biopsy or resection of the lung nodules Exclusion Criteria: * claustrophobia * pregnant or breastfeeding * interval of at least 2 weeks between PET scan and last date of systemic anti-cancer therapy to reduce false-negative uptake in lesions * radiation therapy of the target lung nodule(s) * uncontrolled diabetes mellitus * any medical condition potentially hampering conduction of the trial
Where it's running
-
University Medical Center Groningen
Groningen, Netherlands Recruiting
Study contacts
- Principal investigator: Adrienne H Brouwers, MD PhD — Nuclear Medicine physician
- Study coordinator: Adrienne H Brouwers, MD PhD
- Email: a.h.brouwers@umcg.nl
- Phone: +31503613093
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.