Subtyping Primary Aldosteronism With Para-chloro-2-[18F]Fluoroethyl-etomidate

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

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Why it matters

Who can join: the full rules

Inclusion Criteria:

* above 18 years
* Biochemically established diagnosis of PA\*
* Completion of standard diagnostic work-up of PA\*
* Able to follow and understand instructions to participate in the study
* Able to give written informed consent.

Exclusion Criteria:

* diabetes mellitus (i.e., HbA1c above 42 mmol/mol, and/or fasting plasma glucose \> 7.0 mol/l or non-fasting plasma glucose above 11.1 mmol/L )
* serious comorbidities precluding surgery
* severe claustrophobia
* pregnancy/breastfeeding or unable/unwilling to take adequate contraceptives (female only)
* concurrent active infections (e.g., viral, fungal or parasite infections)\*\*
* problematic venous access
* unable/unwilling to take dexamethasone prior to \[18F\]CETO scanning
* inability to temporary stop medication affecting aldosterone secretion
* use of ketoconazole, metyrapone or cytostatic drugs during previous 6 months\*\*\*
* long-term use of prednisolone and/or dexamethasone.

Where it's running

• University Medical Center Groningen
  Groningen, Provincie Groningen, Netherlands Recruiting

Study contacts

• Principal investigator: Dr. M.N. Kerstens — Department of Internal Medicine - Endocrinology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
• Study coordinator: dr. M.N. Kerstens
• Email: m.n.kerstens@umcg.nl
• Phone: +31 0503613518

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.