Developing models to predict complications after treatment for esophageal cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project aims to develop and validate prediction models for complications following neoadjuvant chemoradiotherapy (nCRT) and surgical resection in patients with esophageal cancer. The study will evaluate two strategies: creating separate models for various complications and a composite model that summarizes all complications into a single score. By linking data from existing cancer registries and a radiotherapy database, the study will analyze over 2000 patient records to optimize radiotherapy planning and improve patient selection. The goal is to enhance treatment outcomes by predicting potential complications more accurately.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Tumor in the esophagus, histologically proven or suspect for esophageal carcinoma
* WHO performance 0-2
* Age\>18years
* No distant metastasis (M0)
* Treated with nCRT and planned for or followed by an esophagectomy between 2015 and 2021 in one of the participating centers.

Exclusion Criteria:

* Sarcoma, neuro-endocrine or small cell carcinoma of the esophagus
* Patients who underwent a surgical resection in a non-participating surgical center will be excluded

Where it's running

• Radboud UMC
  Nijmegen, Gelderland, Netherlands Recruiting
• Maastro clinic
  Maastricht, Limburg, Netherlands Recruiting
• Amsterdam UMC
  Amsterdam, North Holland, Netherlands Recruiting
• Erasmus MC
  Rotterdam, South Holland, Netherlands Recruiting
• Umcg
  Groningen, Netherlands Recruiting
• Zuyderland hospital
  Heerlen, Netherlands Recruiting

Study contacts

• Study coordinator: Christina Muijs, Dr.
• Email: c.t.muijs@umcg.nl
• Phone: 0503616161

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.