Can FAPI or FDG PET/CT help diagnose active Peyronie's disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot interventional study evaluates if two PET imaging methods, 68Ga-FAPI-PET/CT and FDG-PET/CT, can identify active fibroblasts and inflammation in patients with acute or chronic Peyronie’s disease. Eligible adults with either an acute phase (painful erections, recent nodule) or chronic phase (stable curvature, nodule, no pain for 6 months) undergo both scans after diagnosis. The goal is to determine whether these imaging tests can distinguish active disease from end-stage fibrosis to guide future therapies. The lead sponsor is University Medical Center Groningen, with collaboration from St. Antonius Hospital, at sites in Nieuwegein and Utrecht.

Why it matters

Who can join: the full rules

Inclusion Criteria men \>18 years of age

* mentally competent and understanding of benefits and potential burden of the study
* be able to sign written informed consent
* read and understand the Dutch language active phase:
* painful erections,
* with onset for \< 6 months
* palpable nodule
* men \>18 years of age chronic phase:
* Stable curvature of at least 6 months
* No painful erections for at least 6 months
* Palpable nodule

Exclusion Criteria:

* \- Known other malignant disease
* For acute phase: Previous treatment for PD
* for chronic phase: Previous surgical treatment or treatment by injections for PD

Where it's running

• St Antoniusziekenhuis
  Nieuwegein, Utrecht, Netherlands Recruiting

Study contacts

• Study coordinator: Jeannette P Geelhoed, MSc
• Email: j.p.geelhoed@umcg.nl
• Phone: +3119931803

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.