Warm machine perfusion for older deceased-donor kidneys before transplant

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

REWARM is a randomized, controlled, multicenter trial in three Dutch transplant centers comparing an extra six-hour period of normothermic machine perfusion (after standard hypothermic machine perfusion) to standard care with hypothermic machine perfusion alone. Eligible kidneys come from deceased donors aged 50 years or older and are donated after circulatory or brain death. Adult recipients receiving their first or second kidney transplant at UMCG, Erasmus MC, or LUMC are randomized, with a target enrollment of 240 patients (120 per arm) over about 2.5–3 years. The primary outcome is renal function measured at 12 months post-transplant, with secondary outcomes addressing graft complications and survival.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients receiving their first or second kidney transplant;
* Patients receiving a graft from a ≥ 50-year-old donor;
* Patients receiving a graft from a DCD or DBD donor;
* Patients receiving a kidney transplant in the UMCG, the Erasmus MC, or the LUMC;
* Patients receiving a graft stored on HMP;
* Patients ≥ 18 years of age;
* Patients having provided written informed consent.

Exclusion Criteria:

* Patients receiving their third or subsequent kidney transplant;
* Patients receiving a graft from a donor \< 50 years;
* Patients receiving a graft not stored on HMP;
* Patients receiving a graft from a donor that underwent normothermic regional perfusion (NRP);
* Patients receiving a kidney transplant in another center than the UMCG, Erasmus MC, or LUMC;
* Patients receiving a multi-organ transplantation;
* Patients receiving a kidney with complex arterial anatomy (3 or more arteries);
* Recipients \< 18 years of age.

Where it's running

• University Medical Center Groningen
  Groningen, Provincie Groningen, Netherlands Recruiting
• Erasmus Medical Center
  Rotterdam, Netherlands Recruiting
• Leiden University Medical Center
  Leiden, Netherlands Not yet recruiting

Study contacts

• Study coordinator: Cyril Moers, MD, PhD
• Email: c.moers@umcg.nl
• Phone: 0619602619

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.