Iodine uptake in thyroid cancer patients after a low iodine diet
Official title: The Uptake of Radioactive Iodine Before and After a Low Iodine Diet in Patients With Differentiated Thyroid Carcinoma
Run by University Medical Center Groningen · NCT05599139 · Data updated 2026-11-12
This study is testing whether a low iodine diet for 7 days can help improve how well radioactive iodine is taken up by the thyroid in patients with thyroid cancer who are getting ready for treatment.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 25 (estimated) |
| Sponsor | University Medical Center Groningen Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Groningen, Provincie Groningen) |
| Status | Recruiting |
| Started | February 22, 2023 |
| Main results expected | March 30, 2026 |
| Study ends | August 31, 2026 |
| Registry record updated | February 6, 2026 |
| Trial ID | NCT05599139 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults over 18 diagnosed with differentiated thyroid carcinoma who can adhere to a low iodine diet.
✕Probably not a fit
Patients under 18, those with renal impairment, or those who have recently used iodinated contrast or are pregnant may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to evaluate the difference in thyroid uptake of low dose radioactive iodine in patients with differentiated thyroid carcinoma before and after following a low iodine diet for 7 days. The study will measure iodine uptake in athyreotic patients who have undergone total thyroidectomy and are preparing for ablation therapy. By comparing the uptake percentages before and after the diet, researchers hope to gather prospective data on the effectiveness of the low iodine diet in enhancing iodine uptake during treatment.
Why it matters
Potential benefit: If successful, this study could improve the effectiveness of radioactive iodine therapy in patients with differentiated thyroid cancer.
How similar studies have gone: While there is limited prospective data on this approach, previous studies have shown mixed results regarding the effectiveness of low iodine diets in enhancing iodine uptake.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients, men and women above the age of 18 years, have to be diagnosed with DTC and have to follow a LID prior to the 131I ablation therapy according to the Dutch DTC guideline * Patients have to be fit to adhere to the study protocol * Patients have to be able to read and understand the Dutch language Exclusion Criteria: * Age \< 18 years * Patients using amiodarone * Patients receiving iodinated contrast \< 3 months before the LID * Pregnancy * Patients prepared for ablation therapy with rhTSH * Renal impairment, EGFR \<30ml/min/1,73m2
Where it's running
-
Umcg
Groningen, Provincie Groningen, Netherlands Recruiting
Study contacts
- Principal investigator: Wouter Zandee, Dr. — University Medical Center Groningen
- Study coordinator: Wouter Zandee, Dr.
- Email: w.t.zandee@umcg.nl
- Phone: +31503613731
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.