Congestion profiles in adults hospitalized with acute heart failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective observational study enrolling 270 adults admitted with acute heart failure who require intravenous loop diuretics. Participants will undergo bedside assessments including ultrasound of filling pressures, lungs, and kidneys, liver Fibroscan, and sublingual sidestream darkfield imaging, with additional biomarker substudies (GLYCO-AHF and PREACH-AHF). The primary aim is to identify distinct congestion phenotypes and link them to 24-hour natriuresis and the composite outcome of all-cause mortality or heart failure rehospitalization at 6 months. Exploratory outcomes include length of hospital stay, congestion at discharge, and changes in filling pressures over time.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Able and willing to give written informed consent
* Age ≥ 18 years
* Male or female
* Primary diagnosis of acute heart failure at presentation, with signs and symptoms of tissue decongestion. Diagnosis is based on the criteria in the ESC HF guidelines (1)
* Requirement of intravenous loop diuretics

Exclusion Criteria:

* Patients with severe kidney dysfunction (in need for ultrafiltration or dialysis)
* Previous participation in this study
* Inability to follow instructions
* Dyspnoea or oedema primarily due to non-cardiac causes

Where it's running

• Umcg
  Groningen, Netherlands Recruiting

Study contacts

• Study coordinator: Jozine M. ter Maaten, MD, PhD
• Email: j.m.ter.maaten@umcg.nl
• Phone: +31503616161

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.