Hinting Task to measure social thinking in Huntington's disease
Official title: Sensitivity of the Hinting Task in Patients With Huntington's Disease
Run by University Medical Center Groningen · NCT06774443 · Data updated 2026-11-12
This research will test whether the Hinting Task can reliably measure Theory of Mind (social thinking) in Dutch-speaking adults with Huntington's disease.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 74 Years |
| Sex | All |
| Enrollment | 52 (estimated) |
| Sponsor | University Medical Center Groningen Academic / other |
| Locations | 1 site (Groningen, Provincie Groningen) |
| Status | Recruiting |
| Started | September 1, 2025 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | January 29, 2026 |
| Trial ID | NCT06774443 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Dutch-speaking adults aged 18–74 with genetically confirmed Huntington's disease (CAG repeat ≥40) and no serious psychiatric or other neurological disorders.
✕Probably not a fit
People who are non-Dutch speakers, outside the 18–74 age range, or who have serious psychiatric conditions or other neurological comorbidities may not benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational project uses neuropsychological assessments, including the Hinting Task, to measure Theory of Mind (social cognition) in Dutch-speaking adults with genetically confirmed Huntington's disease. Participants aged 18–74 with a CAG repeat ≥40 will complete the Hinting Task along with other cognitive and behavioural measures to compare performance and establish norms. The protocol excludes people with serious psychiatric disorders or other neurological comorbidities to isolate Huntington's-related social cognitive changes. All testing is performed at University Medical Center Groningen to collect standardized Dutch-language data for validation and future clinical use.
Why it matters
Potential benefit: If successful, clinicians would have a simple, validated Dutch test to detect social cognition deficits in Huntington's disease, helping to guide care and support for patients and caregivers.
How similar studies have gone: The Hinting Task has been useful in measuring Theory of Mind in other conditions such as schizophrenia and some neurodegenerative disorders, but it has limited validation specifically in Dutch Huntington's disease cohorts.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Confirmed diagnosis of Huntington's disease via CAG-repeat length analysis, minimum of 40 repeats * Between 18 and 74 years of age * Dutch speaking Exclusion Criteria: * Presence of serious psychiatric disorders or other neurological comorbidities
Where it's running
-
University Medical Center Groningen
Groningen, Provincie Groningen, Netherlands Recruiting
Study contacts
- Principal investigator: Maraike Coenen — University Medical Center Groningen
- Study coordinator: Floor Gelmers
- Email: f.gelmers@umcg.nl
- Phone: +31 50 361 46 64
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.