Clinical trial Recruiting at 1 site Observational Ages 18 to 74

Hinting Task to measure social thinking in Huntington's disease

Official title: Sensitivity of the Hinting Task in Patients With Huntington's Disease

Run by University Medical Center Groningen · NCT06774443 · Data updated 2026-11-12

This research will test whether the Hinting Task can reliably measure Theory of Mind (social thinking) in Dutch-speaking adults with Huntington's disease.

Quick facts

Study typeObservational
Ages18 Years to 74 Years
SexAll
Enrollment52 (estimated)
SponsorUniversity Medical Center Groningen
Academic / other
Locations1 site (Groningen, Provincie Groningen)
StatusRecruiting
StartedSeptember 1, 2025
Main results expectedDecember 31, 2026
Study endsDecember 31, 2026
Registry record updatedJanuary 29, 2026
Trial IDNCT06774443 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Dutch-speaking adults aged 18–74 with genetically confirmed Huntington's disease (CAG repeat ≥40) and no serious psychiatric or other neurological disorders.

Probably not a fit

People who are non-Dutch speakers, outside the 18–74 age range, or who have serious psychiatric conditions or other neurological comorbidities may not benefit or be eligible.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational project uses neuropsychological assessments, including the Hinting Task, to measure Theory of Mind (social cognition) in Dutch-speaking adults with genetically confirmed Huntington's disease. Participants aged 18–74 with a CAG repeat ≥40 will complete the Hinting Task along with other cognitive and behavioural measures to compare performance and establish norms. The protocol excludes people with serious psychiatric disorders or other neurological comorbidities to isolate Huntington's-related social cognitive changes. All testing is performed at University Medical Center Groningen to collect standardized Dutch-language data for validation and future clinical use.

Why it matters

Potential benefit: If successful, clinicians would have a simple, validated Dutch test to detect social cognition deficits in Huntington's disease, helping to guide care and support for patients and caregivers.

How similar studies have gone: The Hinting Task has been useful in measuring Theory of Mind in other conditions such as schizophrenia and some neurodegenerative disorders, but it has limited validation specifically in Dutch Huntington's disease cohorts.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Confirmed diagnosis of Huntington's disease via CAG-repeat length analysis, minimum of 40 repeats
* Between 18 and 74 years of age
* Dutch speaking

Exclusion Criteria:

* Presence of serious psychiatric disorders or other neurological comorbidities

Where it's running

  • University Medical Center Groningen
    Groningen, Provincie Groningen, Netherlands
    Recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.