Hinting Task to measure social thinking in Huntington's disease
Sensitivity of the Hinting Task in Patients With Huntington's Disease
This research will test whether the Hinting Task can reliably measure Theory of Mind (social thinking) in Dutch-speaking adults with Huntington's disease.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 52 (estimated) |
| Ages | 18 Years to 74 Years |
| Sex | All |
| Sponsor | University Medical Center Groningen Academic / other |
| Locations | 1 site (Groningen, Provincie Groningen) |
| Trial ID | NCT06774443 on ClinicalTrials.gov |
What this trial studies
This observational project uses neuropsychological assessments, including the Hinting Task, to measure Theory of Mind (social cognition) in Dutch-speaking adults with genetically confirmed Huntington's disease. Participants aged 18–74 with a CAG repeat ≥40 will complete the Hinting Task along with other cognitive and behavioural measures to compare performance and establish norms. The protocol excludes people with serious psychiatric disorders or other neurological comorbidities to isolate Huntington's-related social cognitive changes. All testing is performed at University Medical Center Groningen to collect standardized Dutch-language data for validation and future clinical use.
Who should consider this trial
Good fit: Dutch-speaking adults aged 18–74 with genetically confirmed Huntington's disease (CAG repeat ≥40) and no serious psychiatric or other neurological disorders.
Not a fit: People who are non-Dutch speakers, outside the 18–74 age range, or who have serious psychiatric conditions or other neurological comorbidities may not benefit or be eligible.
Why it matters
Potential benefit: If successful, clinicians would have a simple, validated Dutch test to detect social cognition deficits in Huntington's disease, helping to guide care and support for patients and caregivers.
How similar studies have performed: The Hinting Task has been useful in measuring Theory of Mind in other conditions such as schizophrenia and some neurodegenerative disorders, but it has limited validation specifically in Dutch Huntington's disease cohorts.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Confirmed diagnosis of Huntington's disease via CAG-repeat length analysis, minimum of 40 repeats * Between 18 and 74 years of age * Dutch speaking Exclusion Criteria: * Presence of serious psychiatric disorders or other neurological comorbidities
Where this trial is running
Groningen, Provincie Groningen
- University Medical Center Groningen — Groningen, Provincie Groningen, Netherlands (Recruiting)
Study contacts
- Principal investigator: Maraike Coenen — University Medical Center Groningen
- Study coordinator: Floor Gelmers
- Email: f.gelmers@umcg.nl
- Phone: +31 50 361 46 64
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.