Using CPAP or BiPAP to reduce tumor movement during radiotherapy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the feasibility of using CPAP and BiPAP to control breathing patterns in patients with intra-thoracic tumors undergoing radiotherapy. In the first phase, the effects of these ventilators on lung volumes and breathing frequency will be assessed in a small group of patients. The second phase will involve evaluating the optimal settings determined in phase one during repeated radiotherapy planning CT scans to measure their impact on tumor motion and radiation dose to surrounding organs. The goal is to enhance treatment precision for patients with advanced stage cancers.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years
* Stage III/IV (N)SCLC, esophageal cancer or malignant lymphoma that will be treated with curative intent
* WHO 0-2.
* Written informed consent

Exclusion Criteria:

* Facial deformations so that facial mask is impossible to fit
* Noncompliance with any of the inclusion criteria.
* Planned for radiotherapy with fraction dose ≥3 Gy.
* Severe heart failure (LVEF\<30%)

Where it's running

• University Medical Center Groningen
  Groningen, Provincie Groningen, Netherlands Recruiting

Study contacts

• Principal investigator: Robin Wijsman — University Medical Center Groningen
• Study coordinator: Robin Wijsman
• Email: info@rt.umcg.nl
• Phone: +31503612711

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.