Carotid artery stenting during treatment of acute stroke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the safety and efficacy of immediate carotid artery stenting (CAS) during endovascular thrombectomy (EVT) for patients suffering from acute ischemic stroke due to large vessel occlusion. The study aims to determine whether performing CAS can improve cerebral blood flow and reduce the risk of recurrent strokes compared to standard treatment. Participants will be randomly assigned to receive either CAS or usual care during their EVT procedure. The trial focuses on patients with significant carotid artery stenosis or occlusion, assessing both the potential benefits and risks associated with the intervention.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Acute ischemic stroke due to proximal intracranial occlusion in the anterior circulation (intracranial ICA, M1, proximal M2) on the CT angiography
2. Stenosis \>50% according to the NASCET criteria16 or initial occlusion of the ipsilateral cervical carotid artery of presumed atherosclerotic origin on baseline CT angiography
3. Eligible for EVT according to the guidelines: EVT within 6 hours of onset or EVT between 6-24 hours after onset based on perfusion CT imaging selection (conform current guidelines)
4. Baseline National Institute of Health Stroke Scale (NIHSS) score ≥2
5. Age \>18 years
6. Written informed consent (deferred consent)

Exclusion Criteria:

1. Any intracranial hemorrhage
2. Cervical carotid artery stenosis or occlusion with other causes than presumed atherosclerosis (e.g. carotid artery dissection, floating thrombus, carotid web)
3. Any exclusion criterion for EVT according to the guidelines
4. Pre stroke disability (defined as a modified Rankin Scale score \>2)
5. Recent gastro-intestinal or urinary tract hemorrhage (\<6 weeks)
6. Recent severe head trauma (\<6 weeks)
7. Recent infarction on baseline brain CT in the same vascular territory (\<6 weeks)
8. Known allergy to aspirin and/or clopidogrel
9. Pregnancy

Where it's running

• University Medical Center Groningen
  Groningen, Netherlands Recruiting

Study contacts

• Principal investigator: Maarten Uyttenboogaart, MD PhD — University Medical Center Groningen
• Study coordinator: Maarten Uyttenboogaart, MD PhD
• Email: m.uyttenboogaart@umcg.nl
• Phone: +31 50 3612400

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Effectiveness of a new neurorehabilitation technology for stroke recovery

  This study is testing a new rehabilitation technology that uses robots and virtual reality to see if it can help stroke patients recover better than regular therapy.

  Recruiting Neurotechnika · Samara, Samara Oblast · NCT06753006

• HR-MRI–Directed Tirofiban Therapy for Late-Window ICAS-LAA Stroke

  We’re testing whether tirofiban plus dual antiplatelet therapy, guided by high-resolution MRI of the brain’s blood vessels, can help people with intracranial large-artery atherosclerosis strokes that begin more than 24 hours after onset.

  Recruiting Phase 3 Weifang Medical University · Weifang, China/Shandong Province · NCT07379190

• Emergency Stroke Unit for treating acute strokes

  This study is testing a new Emergency Stroke Unit that uses a mobile MRI to see if it can help treat stroke patients faster and improve their recovery.

  Recruiting Chinese University of Hong Kong · Hong Kong · NCT06728592

• Tenecteplase versus alteplase before mechanical thrombectomy for acute large-vessel ischemic stroke

  This trial tests whether tenecteplase given before mechanical thrombectomy helps adults with acute large-vessel ischemic stroke within 4.5 hours recover better than standard alteplase.

  Recruiting Phase 3 Xuanwu Hospital, Beijing · Beijing, Beijing Municipality · NCT06658197

• Monitoring brain-derived tau levels in acute ischemic stroke patients

  This study is testing how brain-derived tau levels change in stroke patients over 48 hours to see if it can help understand their condition and improve treatment decisions.

  Recruiting Ludwig-Maximilians - University of Munich · Munich, Bavaria · NCT06121336

• Using the Atalante exoskeleton to help stroke patients walk again

  This study is testing if using the Atalante exoskeleton can help stroke patients walk better compared to regular therapy.

  Recruiting at 4 sites Wandercraft · Créteil and 4 other locations · NCT06107010

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.