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Clinical trials and research at St. Jude Children's Research Hospital

• 95Clinical trials
• 348NIH research projects
• 2New in 30 days
• 6Countries

Newest trials

All recruiting trials (95)

• Feasibility of Remote Saliva and Sleep Monitoring for ALL Survivors

  This study tests whether collecting saliva, blood, hair, and nail samples, along with sleep tracking and surveys, is practical and acceptable for childhood ALL survivors and their siblings.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07884474

• Stigma Healing Inventory: See if a global program can reduce stigma for kids with cancer and their caregivers

  This study tests a stigma-reduction program for children with cancer and their caregivers to see if it lowers stigma across different cultures.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07882927

• Using a bioimpedance device to track fluid status in children after stem cell transplant

  The study tests whether bedside bioimpedance measurements can reliably track body water changes in children undergoing stem cell transplantation, alongside standard fluid checks.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07834710

• Cognitive training with real-time brain feedback for childhood medulloblastoma survivors

  This study tests whether real-time brain feedback using rt-fMRI or rt-fNIRS can help children and young adults who survived childhood medulloblastoma improve attention and working memory.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07830134

• Pregnancy-time treatment of fetal SMA: a registry of mother-child outcomes

  This registry collects information on pregnancies where a fetus diagnosed with spinal muscular atrophy was treated with a disease‑modifying therapy in the womb to see how the pregnancy and baby fare after birth.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07805278

• Newborn Sickle Cell Screening in Mozambique

  We’re testing a three-part plan to help babies in Mozambique get diagnosed early for sickle cell disease and start care quickly.

  Recruiting St. Jude Children's Research Hospital · Nhamatanda, Sofala · NCT07719972

• Brain mapping of UCD patients during simulated driving

  This study tests how brains function in people with urea cycle disorders while they do driving tasks in a simulator, compared with healthy controls.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07701694

• Conversations About Hope Between Bereaved Parents and Learners at St. Jude

  This study tests whether virtual conversations about how hope changes during a child’s cancer journey between bereaved parent advisors and learners at St. Jude can be feasible, acceptable, and beneficial.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07675083

• Understanding how bereaved parents and their child’s oncologist talk about prognosis when there’s uncertainty

  This study asks bereaved parents of children who had cancer and their child’s oncologist to share how they talked about prognostic uncertainty and what could help improve those conversations.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07663539

• Haploidentical donor transplant for sickle cell disease in young patients

  This trial tests a gentler conditioning regimen and a post-transplant medication plan to see if children and young adults with sickle cell disease can have a successful haploidentical hematopoietic cell transplant with limited GVHD.

  Recruiting Phase 2 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07616154

• Characterizing Subclinical ASCVD in Childhood Cancer Survivors

  This study tests whether detailed heart and blood vessel imaging and blood tests can reveal early signs of atherosclerosis in adult survivors of childhood cancer compared with community controls.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07594392

• Stem cell mobilization and collection for life-threatening blood disorders

  This study tests a FIlgrastim plus plerixafor approach to safely mobilize and collect stem cells from adults with bone marrow failure for potential gene therapy.

  Recruiting Phase 1 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07585136

• Muscle Health Endotypes in Childhood Cancer Survivors

  This study tests whether adult survivors of childhood cancer have different muscle health endotypes using advanced imaging and neuromuscular testing to guide future targeted interventions.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07531498

• Screening and brief counseling for substance use in adult survivors of childhood cancer

  This study tests whether a short, evidence-based substance-use screening plus a brief counseling session can be added into routine survivorship care for adult survivors of childhood cancer at St. Jude.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07516301

• Adaptive Proton Therapy for Pediatric Solid Tumors and Hodgkin Lymphoma

  This study tests a regular imaging approach to see if proton therapy plans for children with solid tumors or Hodgkin lymphoma should be updated during treatment.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07514819

• Deep phenotyping of walking problems after lower-limb orthopedic surgery in children treated for cancer

  We will use motion-capture labs and wearable sensors to see how walking problems develop and change over time in children and teens (ages 5–20) who have lower-limb orthopedic surgery for bone or soft tissue sarcoma or steroid-induced avascular necrosis, and compare them to healthy peers.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07502885

• Transition outcomes for adolescents and young adults with a cancer predisposition.

  See if young adults with a genetic cancer predisposition establish and keep up care with adult providers and follow recommended cancer surveillance after they leave pediatric care at St. Jude.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07456904

• Photo-based exploration of hope in young people receiving phase 1/2 cancer therapy

  This project will try to understand how young people (ages 12–25) and their caregivers experience and adapt their hope while they are enrolled in phase 1 or 2 cancer therapy using photos and interviews.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07444216

• End-of-chemotherapy B7-H3 CAR T cells for high-risk pediatric osteosarcoma

  This study tests whether giving a patient’s own B7-H3 CAR T cells after standard chemotherapy can help treat newly diagnosed high-risk osteosarcoma in children.

  Recruiting Phase 2 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07428993

• Ovarian reserve during puberty in girls with sickle cell disease

  This project will test whether AMH blood levels, a marker of ovarian reserve, differ during puberty in girls aged 10 to <19 with sickle cell disease compared with healthy girls.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07392216

• Families and clinicians shaping ethical standards for personalized care in rare neurological diseases

  This project will talk with patients, families, clinicians, and researchers to see which ethical issues matter most when using personalized treatments for children with ultrarare neurological disorders.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07314736

• CD19‑CAR T‑cell consolidation after TCRαβ/CD19‑depleted haploidentical family donor transplant for relapsed/refractory CD19+ B‑cell leukemia and lymphoma

  This will try giving CD19‑targeted CAR T cells shortly after a partially matched family‑donor transplant to children and young adults (≤21) with relapsed or refractory CD19+ B‑cell leukemia or lymphoma to see if the approach is safe and feasible.

  Recruiting Phase 1 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07257419

• Healthy Hearts: improving heart screening for adult childhood cancer survivors

  This trial tests an online Healthy Hearts program to help adult childhood cancer survivors at higher heart risk get the recommended echocardiogram screening.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07245420

• Tirzepatide plus guided resistance exercise for weight loss in adult survivors of childhood ALL

  This 28-week program will try once-weekly tirzepatide together with remote, supervised resistance training to help adult survivors of childhood ALL who have obesity or overweight with a related health condition lose weight.

  Recruiting Phase 2 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07228741

• Methylphenidate for attention and executive problems in children with sickle cell disease

  This study will test whether once-daily extended-release methylphenidate for 4 weeks helps attention and thinking skills in children 8–17 with sickle cell disease while monitoring side effects and adherence.

  Recruiting Phase 1 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07226219

• Hypofractionated radiation plus B7-H3 CAR T cells for children and young adults with relapsed sarcoma

  This will test whether short-course radiation given before B7-H3 CAR T-cell therapy is safe for children and young adults (≤21) with relapsed or refractory B7-H3–positive sarcomas.

  Recruiting Phase 1 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07222735

• 12-week high-intensity interval training for recent survivors of childhood and young-adult Hodgkin lymphoma

  This test tries a 12-week, remotely supervised high-intensity interval training (HIIT) program to see if recently treated survivors of childhood, adolescent, and young adult Hodgkin lymphoma can complete the program and improve fitness and health markers.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07222345

• Noninvasive ear vagus nerve stimulation for insomnia in adult survivors of childhood ALL

  This tests whether nightly noninvasive ear vagus nerve stimulation can improve sleep in adult survivors of childhood acute lymphoblastic leukemia who have moderate to severe insomnia.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07191119

• Culturally adapted mobile cognitive behavioral therapy for chronic pain in adolescent survivors of childhood cancer

  This trial tests whether a culturally adapted mobile cognitive behavioral therapy app can help adolescent survivors of childhood cancer reduce chronic pain and improve daily life, with a caregiver taking part too.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07160621

• Adding N-803 to chemoimmunotherapy for relapsed or refractory neuroblastoma

  This study tests whether adding the immune stimulant N-803 to a chemoimmunotherapy regimen helps children and young adults with relapsed or refractory neuroblastoma.

  Recruiting at 2 sites Phase 2 St. Jude Children's Research Hospital · San Francisco, California and 4 other locations · NCT07085338

• Long-term follow-up for medulloblastoma survivors treated with craniospinal irradiation

  This project will see if people treated for medulloblastoma with craniospinal irradiation have lasting health effects years after treatment.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07085325

• Unwavering Empowering Presence seminar for rehabilitation teams.

  This three-hour communication skills training will try to improve the comfort and confidence of rehabilitation professionals who care for children with serious illness when having difficult conversations with patients and families.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07071116

• TCRαβ‑depleted haploidentical stem cell graft with early memory T‑cell donor lymphocyte infusions and selective blinatumomab for pediatric and young adult blood cancers

  This will test whether giving a TCRαβ‑depleted haploidentical stem cell graft plus early CD45RA‑depleted memory T‑cell infusions, with selective use of blinatumomab for CD19+ disease, is safe for children and young adults undergoing transplant for high‑risk blood cancers.

  Recruiting Phase 1 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07052370

• Long-term health and quality of life after CD19 CAR T-cell therapy in B-ALL survivors

  This project will test whether standardized health checks can be done for children, adolescents, and young adults who are at least two years past CD19 CAR T-cell treatment for B-ALL.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT07048535

• Honest, personalized conversations about prognosis for young people with cancer

  This program tests a step-by-step way to help teens and young adults (ages 12–25) with poor-prognosis cancer and their caregivers share and record how they want doctors to talk about the future.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT06993688

• CAR T cell therapy for young patients with CD19-positive leukemia

  This study is testing a new treatment combining CAR T cell therapy and chemotherapy to see if it helps young patients with hard-to-treat leukemia.

  Recruiting Phase 2 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT06847269

• Examining muscle function in survivors of childhood leukemia

  This study is trying to see how cancer treatment affects muscle strength and function in survivors of childhood leukemia compared to healthy kids.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT06819475

• Prophylaxis with Dalbavancin for Children with High-Risk Leukemia

  This study is testing if giving dalbavancin to children with high-risk leukemia can help prevent serious bacterial infections while they are getting chemotherapy.

  Recruiting Phase 1 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT06810583

• CAR T cell therapy for children with acute lymphoblastic leukemia

  This study is testing a new type of CAR T cell therapy to see if it can safely help children and young adults with hard-to-treat leukemia.

  Recruiting Phase 1 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT06777979

• Remote diagnosis of heart issues in childhood cancer survivors

  This study is testing if a new wrist biosensor can help find heart problems in childhood cancer survivors more easily than regular check-ups.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT06747910

• Long-term follow-up for patients with hemoglobin disorders after transplant or gene therapy

  This study looks at how people with hemoglobin disorders are doing long-term after they’ve had a stem cell transplant or gene therapy to see if there are any lasting effects or problems.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT06646640

• Evaluating the delayed effects of CAR T cell therapy in children

  This study looks at the short-term and long-term side effects of CAR T cell therapy in children with certain types of cancer to see how it affects them over time.

  Recruiting at 7 sites St. Jude Children's Research Hospital · Los Angeles, California and 6 other locations · NCT06579469

• New treatment for children and young adults with newly diagnosed B-cell leukemia and lymphoma

  This study is testing if two new treatments can help children and young adults with newly diagnosed B-cell leukemia and lymphoma achieve better remission results than older therapies.

  Recruiting at 3 sites Phase 2 St. Jude Children's Research Hospital · Charlotte, North Carolina and 2 other locations · NCT06533748

• Examining muscle responses in spinal muscular atrophy patients treated with specific therapies

  This study is testing how different treatments for spinal muscular atrophy affect muscle and nerve responses in patients over a year.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT06532474

• Entrectinib treatment for young children with specific CNS tumors

  This study is testing if a new treatment called entrectinib can help young children under 3 with certain brain tumors feel better and live longer.

  Recruiting at 6 sites Phase 2 St. Jude Children's Research Hospital · Memphis, Tennessee and 5 other locations · NCT06528691

• Gene editing treatment for sickle cell disease

  This study is testing a new gene editing treatment for people with severe sickle cell disease to see if it can improve their health.

  Recruiting Phase 1 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT06506461

• Examining sleep and brain function in children with sickle cell disease

  This study is trying to see how sleep quality affects brain function in children with sickle cell disease by using special devices at home and tests at the clinic.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT06477289

• Using motixafortide to collect stem cells in sickle cell disease patients

  This study is testing if a new drug called motixafortide can safely help people with sickle cell disease collect stem cells for future treatments.

  Recruiting at 3 sites Phase 1 St. Jude Children's Research Hospital · Birmingham, Alabama and 2 other locations · NCT06442761

• Understanding brain function in Hodgkin Lymphoma survivors

  This study is trying to see how treatments for Hodgkin Lymphoma affect brain function in survivors compared to people who haven't had cancer.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT06421987

• Improving treatment responses in children with T-cell leukemia or lymphoma

  This study is testing if adding two new drugs to standard chemotherapy can help children and young adults with T-cell leukemia or lymphoma have better treatment outcomes.

  Recruiting at 4 sites Phase 2 St. Jude Children's Research Hospital · San Diego, California and 3 other locations · NCT06390319

• School readiness program for preschool children with sickle cell disease

  This study is testing a special online school readiness program for preschool kids with sickle cell disease to see if it helps them get ready for school better than regular resources.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT06367192

• CAR T-cell therapy for children with hard-to-treat blood cancers

  This study is testing a new CAR T-cell therapy to see if it can safely help children and young adults with tough-to-treat blood cancers like leukemia and lymphoma.

  Recruiting Phase 1 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT06326463

• Identifying treatment needs for newly diagnosed acute leukemia and lymphoma

  This study is testing a new 7-day chemotherapy treatment for people newly diagnosed with acute lymphoblastic leukemia, lymphoblastic lymphoma, or mixed phenotype acute leukemia to see how well it works and to better understand their risk of recurrence.

  Recruiting at 5 sites Phase 4 St. Jude Children's Research Hospital · San Diego, California and 4 other locations · NCT06289673

• Evaluating treatments for non-rhabdomyosarcoma soft tissue sarcoma in young patients

  This study is testing a combination of chemotherapy and radiation to see if it helps young patients with non-rhabdomyosarcoma soft tissue sarcoma live longer without their cancer coming back.

  Recruiting at 7 sites Phase 1/2 St. Jude Children's Research Hospital · Atlanta, Georgia and 6 other locations · NCT06239272

• Combining revumenib, azacitidine, and venetoclax for treating pediatric and young adult patients with tough cases of acute myeloid leukemia

  This study is testing a new combination of drugs to see if it can help young patients with tough cases of acute myeloid leukemia feel better and achieve remission.

  Recruiting at 10 sites Phase 1 St. Jude Children's Research Hospital · San Diego, California and 9 other locations · NCT06177067

• Measuring quality of life in patients with nodular lymphocyte-predominant Hodgkin lymphoma

  This study is trying to understand how nodular lymphocyte-predominant Hodgkin lymphoma affects the quality of life for both kids and adults by collecting their feedback on symptoms and treatment experiences over time.

  Recruiting at 7 sites St. Jude Children's Research Hospital · Palo Alto, California and 6 other locations · NCT06098430

• Treatment for children with newly diagnosed rhabdomyosarcoma using targeted chemotherapy

  This study is testing a new combination of chemotherapy drugs to see if it helps children with newly diagnosed rhabdomyosarcoma live longer and healthier lives.

  Recruiting at 2 sites Phase 2 St. Jude Children's Research Hospital · Palo Alto, California and 2 other locations · NCT06023641

• Writing exercises for young cancer patients

  This study tests if writing about their cancer experiences can help young patients aged 15-25 feel better and improve their well-being.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT05975333

• Venetoclax combined with chemotherapy for children with acute myeloid leukemia

  This study is testing if adding venetoclax to standard chemotherapy can help children with acute myeloid leukemia feel better and improve their chances of recovery.

  Recruiting Phase 2 St. Jude Children's Research Hospital · Madera, California and 9 other locations · NCT05955261

• Cognitive training using virtual reality for children with brain tumors undergoing radiotherapy

  This study is testing whether virtual reality brain training can help children with brain tumors feel better while they receive radiotherapy compared to using an iPad for the same training.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT05947045

• Understanding Parent-Child Communication About Cancer Risk in Young People

  This study looks at how parents talk to their kids and young adults about their genetic test results for cancer risk to see what helps or makes it harder for them to communicate.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT05849155

• Understanding patient needs for gene therapy in sickle cell disease

  This study talks to patients and their families about what they think and need to know about gene therapy for sickle cell disease to help create better educational resources for them.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT05810181

• Long-term follow-up for patients who received genetically modified cell therapy

  This study is tracking the long-term health effects of gene therapy in patients with blood cancers to see how they are doing 15 years after treatment.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT05713214

• Using donor T-cells to treat viral infections after stem cell transplantation

  This study is testing if special immune cells from related donors can help patients who had a stem cell transplant fight off viral infections like CMV and ADV.

  Recruiting Phase 2 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT05664126

• Using fecal microbiota transplantation to treat gastrointestinal issues in children after stem cell transplants

  This study is testing whether giving fecal microbiota transplants can help children with gut problems after they’ve had a stem cell transplant.

  Recruiting Phase 1 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT05664113

• Using a dye to help find lymph nodes in children with solid tumors

  This study is testing a special dye to see if it can help doctors find lymph nodes in children with solid tumors during surgery, making it easier to plan their treatment.

  Recruiting at 3 sites Early Phase 1 St. Jude Children's Research Hospital · Chicago, Illinois and 2 other locations · NCT05645523

• Investigating heart blood flow and function in sickle cell disease

  This study is testing how blood flow and heart function are affected in people with sickle cell disease to see if it leads to heart problems.

  Recruiting Phase 2 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT05583721

• Targeted therapy for young children with newly diagnosed medulloblastoma

  This study is testing a new targeted treatment for young children with medulloblastoma to see if it helps them live longer without the disease and how it affects their thinking skills.

  Recruiting at 10 sites Phase 2 St. Jude Children's Research Hospital · Palo Alto, California and 9 other locations · NCT05535166

• Combining cyclophosphamide, sorafenib, bevacizumab, and atezolizumab for children and young adults with relapsed solid tumors

  This will test whether giving atezolizumab and bevacizumab every three weeks together with daily cyclophosphamide and dose‑adjusted sorafenib is safe and can shrink relapsed or hard‑to‑treat solid tumors in children and young adults, including fibrolamellar carcinoma.

  Recruiting Phase 1/2 St. Jude Children's Research Hospital · Germantown, Tennessee and 1 other locations · NCT05468359

• Understanding parental decisions in pediatric cancer clinical trials

  This study looks at what factors influence parents' choices about enrolling their child in cancer clinical trials to better understand their decisions.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT05454618

• Evaluating how pediatric cancer patients respond to the flu vaccine

  This study is testing how well the flu vaccine works in children with cancer to see if it helps them build immunity against the virus.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT05384288

• Proton beam radiation for treating Wilms tumor in children

  This study tests if proton beam radiation can safely treat Wilms tumor in children while protecting healthy tissues better than regular radiation.

  Recruiting Phase 2 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT04968990

• Evaluating mirdametinib for low-grade glioma in young patients

  This study is testing a new drug called mirdametinib to see if it can safely help young patients with low-grade glioma feel better and live longer.

  Recruiting Phase 1/2 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT04923126

• Onivyde combined with talazoparib or temozolomide for children and young adults with recurrent solid tumors and Ewing sarcoma

  This will test whether adding talazoparib or temozolomide to Onivyde helps children and young adults whose solid tumors or Ewing sarcoma have come back.

  Recruiting at 8 sites Phase 1/2 St. Jude Children's Research Hospital · Palo Alto, California and 9 other locations · NCT04901702

• B7-H3 CAR T-cell therapy for pediatric solid tumors

  This study is testing a new type of immune therapy using specially modified T cells to see if it can help children with tough-to-treat solid tumors.

  Recruiting Phase 1 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT04897321

• Treatment for relapsed or refractory CD19-positive leukemia using allogeneic memory T-cells

  This study is testing a new CAR T-cell therapy using special immune cells to see if it can help young people with tough-to-treat leukemia feel better.

  Recruiting Phase 1 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT04881240

• Using cold cap therapy to prevent hair loss in children undergoing chemotherapy

  This study is testing if a cold cap can help children keep their hair while they receive chemotherapy for cancer and other conditions.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT04764357

• Using discarded bone marrow to improve treatments for blood disorders

  This study is trying to see if using leftover bone marrow from patients with blood disorders can help develop better gene therapies and drug treatments for conditions like sickle cell disease and β-thalassemia.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT04671212

• Haploidentical transplant for severe aplastic anemia

  This study is testing a new type of stem cell transplant for people with severe aplastic anemia to see if it can help them recover better and reduce the risk of complications.

  Recruiting Phase 2 St. Jude Children's Research Hospital · Memphis, Tennessee · NCT04558736

• Genomic and gene therapy needs for families and patients with sickle cell disease

  This project uses interviews and surveys to see if better information and a web-based tool can help parents and teens with sickle cell disease understand genomic sequencing and treatment options.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT04416178

• CD123-CAR T-cell therapy for treating acute myeloid leukemia and related conditions

  This study is testing a new type of T-cell therapy to see if it can safely help young people with certain types of leukemia and related blood disorders.

  Recruiting at 2 sites Phase 1 St. Jude Children's Research Hospital · Memphis, Tennessee and 1 other locations · NCT04318678

• Treatment for pancreatitis caused by asparaginase in young patients

  This study is testing a new treatment called CM4620 to see if it can help children and young adults with pancreatitis caused by asparaginase feel better and avoid serious complications.

  Recruiting at 3 sites Phase 1/2 St. Jude Children's Research Hospital · Charlotte, North Carolina and 2 other locations · NCT04195347

• Using virtual reality to manage pain in sickle cell disease crises

  This study is testing if using virtual reality can help people with sickle cell disease feel less pain during painful crises when combined with their usual treatment.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee and 1 other locations · NCT03353584

• Investigating genetic factors in childhood cancer

  This study is trying to find out if certain genes passed down in families can increase the risk of childhood cancer by looking at samples from kids who have had cancer and their relatives.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT03050268

• Analysis of childhood and adolescent melanocytic lesions

  This study is looking to see how genetic changes in kids and teens with skin lesions, including melanoma, affect their treatment and outcomes, using information collected during their regular medical care.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT02775643

• Investigation of genetics related to blood diseases

  This study is trying to understand the genetics behind blood diseases by collecting samples and health information from people with these conditions and their family members.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT02720679

• Genomic analysis of normal tissues in children with cancer

  This study is trying to find genetic changes in healthy tissues of children with cancer to see how these changes might affect their treatment and understanding of cancer risk.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT02530658

• Observational program for sickle cell disease management and outcomes

  This study is tracking people with sickle cell disease from childhood to adulthood to see how their condition changes over time and how treatments like hydroxyurea affect their health.

  Recruiting at 5 sites St. Jude Children's Research Hospital · Peoria, Illinois and 5 other locations · NCT02098863

• Collecting and banking human tissue samples at St. Jude Children's Research Hospital

  This study is collecting and storing tissue and fluid samples from children with diseases and their family members at St. Jude to help with future research on treatments and outcomes.

  Recruiting at 13 sites St. Jude Children's Research Hospital · Huntsville, Alabama and 13 other locations · NCT01354002

• Long-term health effects of childhood cancer survivors

  This study looks at the long-term health of people who survived cancer as kids to see how their treatments might affect their health later in life.

  Recruiting at 28 sites St. Jude Children's Research Hospital · Birmingham, Alabama and 30 other locations · NCT01120353

• Molecular analysis of pediatric solid tumors

  This study is trying to understand the genetic and molecular features of different childhood solid tumors to find better ways to treat these tough cancers.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT01050296

• Long-term health outcomes for adults who survived childhood cancer

  This study looks at the long-term health of adults who survived childhood cancer to see what health issues they might face as they age and what factors could affect their well-being.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT00760656

• Investigating genetic factors affecting drug response in children

  This study is testing how genetic differences in children with serious illnesses affect how they respond to medications to help create more personalized treatments.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT00730678

• Registry for children with adrenocortical tumors

  This study collects information and samples from children with adrenocortical tumors to learn more about the disease and help improve genetic counseling for families affected by it.

  Recruiting at 2 sites St. Jude Children's Research Hospital · Stanford, California and 4 other locations · NCT00700414

• Collecting data on childhood cancer patients

  This study is trying to gather important long-term health information from children who have been treated for cancer to help improve their care and monitor any lasting effects.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT00684580

NIH-funded research (newest 40 of 348)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Investigating frailty and aging in childhood cancer survivors

  This study is looking at childhood cancer survivors to see how they might face health challenges similar to older adults as they grow up, and it aims to find ways to help them stay strong and healthy by exploring treatments that could improve their well-being.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-9890475

• Investigating a specific type of leukemia in children caused by genetic changes.

  This study is looking at how certain proteins linked to leukemia affect kids and teens with high-risk blood cancers, and the researchers hope to find new ways to treat these conditions by learning more about how the disease works.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-9834651

• Accessible, label-free optical imaging to reveal disease signals

  A brain-friendly, patient-centered imaging approach aims to uncover hidden disease signals in cells and tissues without labels or dyes.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11627327

• Targeting the SCP4 pathway in acute myeloid leukemia (AML)

  Aims to uncover how the SCP4 signaling pathway drives AML and how it could be blocked to help patients.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11617813

• Blocking cancer-causing cMYC tricks after pregnancy changes in the breast

  Researchers are testing how pregnancy and aging reshape the breast before cancer risk, using patient-reinformed models to see if it changes how dangerous cMYC signals behave.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11615605

• Targeting aberrant enhancer landscapes in pancreatic cancer

  A patient-facing look at a project that aims to understand how pancreatic cancer changes its cell identity and what that means for treatment.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11611138

• Understanding how cancer cells change identity to shape treatment responses

  Researchers are developing new genetic tools to map how cancer cells switch their identity, which could reveal new ways to stop therapy resistance.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11603195

• Regulation of innate immune cell death in infectious disease

  A doctor-scientist is studying how the body’s first-line immune cells die and release signals that can help or harm when flu viruses like H5N1 spread, to find ways to prevent dangerous inflammation.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11551494

• Sustainability of pediatric early warning systems to protect children with cancer in low-resource hospitals

  Aimed at keeping children with cancer safer in low-resource hospitals by studying how a simple warning and action system (PEWS) is being adopted and kept going across multiple hospitals.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11540216

• Testing new drug combinations to treat pediatric soft tissue sarcomas

  A pediatric-focused research effort will test new drug combos in living models derived from children's tumors to find ways to improve survival and quality of life.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11537932

• Infant and child immune responses to influenza and COVID-19

  Researchers will use tiny blood samples from infants, children, and adults to learn how their immune systems respond to influenza and COVID-19 infections and vaccines.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11507370

• How babies' immune systems respond to COVID-19 versus the flu

  Researchers will follow infants who had COVID-19, infants who had influenza, and healthy infants to learn how early infections affect their immune protection over the next three years.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11507369

• Infant COVID and Flu Sample Collection and Testing

  Collects blood and nasal samples from infants and young children who have COVID-19 or flu (and from healthy controls) to track infection, viral load, and vaccine responses over the first three years of life.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11507368

• Stem cell problems in Diamond-Blackfan anemia

  This project looks at why blood-forming stem cells don't work well in Diamond-Blackfan anemia by studying the common RPS19 gene change and its effects on TP53 and PRC2 pathways.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11481769

• Better identifying late health problems in adult survivors of childhood cancer

  This project uses computer learning with clinic exams, medical records, genetics, and survey answers to more accurately find conditions like diabetes, high blood pressure, and heart problems in adults who survived childhood cancer.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11471611

• Multi-center pediatric brain and spinal cord tumor treatment network

  Testing early-phase experimental treatments for children and young adults with brain and spinal cord tumors.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11466965

• Targeting CLK2 to Fight Rhabdomyosarcoma

  Aims to see if blocking CLK2 can weaken rhabdomyosarcoma cancer cells, potentially offering a new treatment for kids and young adults.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11454705

• Enhancing Precise Use of Beta-lactam Antibiotics in Immunocompromised Children

  A pediatric cancer care grant aims to tailor beta-lactam antibiotics for children with weakened immune systems who develop serious bloodstream infections.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11454030

• Scaling CAR-T programs for kids: lessons from real-world clinics

  This grant helps train a clinician-researcher to map how pediatric CAR-T programs are set up in different countries and create tools to make it easier to start and sustain these therapies for children with cancer.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11452296

• Co-infection biophysics and transmission of flu and bacteria in the airways

  This grant explores how influenza A virus and bacteria like Streptococcus pneumoniae interact on the airway surfaces and what that means for infection and spread.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11451550

• Contagiousness: How and When It Stops in Flu

  A study to understand when people stop being contagious during flu infection and what factors influence that timing.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11451549

• Understanding how influenza becomes contagious: host, droplets, and environment

  A research team is studying what makes influenza-infected people more contagious by looking at the person, the droplets they breathe out, and the environment, using advanced AI and ferret models.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11451546

• Targeting DDX19A to fight Ewing sarcoma

  A new approach aims to block a protein called DDX19A that helps certain bone cancers grow, with the goal of stopping cancer cells from overreacting and dying off when treated.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11450708

• How Family C GPCRs Signal in the Brain (Autism-related)

  A study at St. Jude is exploring how a specific family of brain receptors relays signals to the brain’s cells, which could help people affected by autism and other brain disorders.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11450611

• LACTB2 and liver metabolism maturity in children and model systems

  Researchers are studying a gene called LACTB2 to understand how a child's liver grows and develops its metabolism.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11450547

• Understanding how ALS-related proteins form phase-separated aggregates

  Researchers are studying how brain-protecting particles called stress granules form and behave in diseases like ALS and Alzheimer’s to find new ways to slow or stop disease progression.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11450000

• Understanding how bone marrow supports fibrotic remodeling in disease

  A study to understand how bone marrow supports fibrosis in blood diseases and to find new ways to help patients with conditions like myelofibrosis.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11448877

• Compartmentalized BCAA Metabolism in AML

  A study at St. Jude investigates how a specific amino acid pathway drives acute myeloid leukemia and whether targeting it could help diagnose or treat the disease.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11447829

• Understanding how chromosome 21 nondisjunction relates to Down syndrome complications

  Researchers are studying how different errors in chromosome 21 division relate to health issues in children with Down syndrome.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11442677

• CD19-CAR T cells after donor transplant to prevent relapse in adults with B-ALL

  This study tests a new way to prevent relapse in adults with B-cell ALL by combining a donor bone marrow transplant with a special CAR T cell treatment, aiming to reduce relapse and avoid total body irradiation.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11434386

• Molecular rules that shape how genome packaging affects disease

  A science team at St. Jude is studying how tightly packed DNA in cells forms different shapes and how that impacts diseases and development.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11429627

• G6PD and asparaginase: a new way to treat colorectal cancer

  Researchers are exploring how blocking a cell enzyme (G6PD) could make colorectal cancer more sensitive to the cancer medicine asparaginase, while sparing normal cells.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11429564

• Base editing and prime editing for sickle cell disease

  Aims to improve treatment for adults with sickle cell disease by using precise genome editing to boost fetal hemoglobin or correct the sickle mutation.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11413777

• Genomic advances to improve outcomes in high-risk acute leukemia

  A physician-scientist team is studying the genetic drivers of pediatric acute leukemia to find new ways to diagnose and treat it, with the goal of improving cure rates for kids.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11413510

• Targeting tumor and T cell DNA methylation to boost CAR T therapy for diffuse midline glioma

  A pediatric brain tumor study aims to improve CAR T cell therapy by tweaking DNA methylation in both tumor cells and CAR T cells to make treatments work better.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11408774

• Understanding how cancer cells survive and die

  Researchers are studying how cancer cells evade death at the molecular level to learn why some cancers resist treatment.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11406321

• Understanding how electric signals affect biofilm growth and antibiotic resistance

  Scientists are studying how electrical signals inside bacterial biofilms influence their growth and resistance to antibiotics so new, smarter treatments can help treat infections.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11400508

• Healthy Hearts: Better Heart Screening for Survivors via Online Support

  A new program tests if an online, nurse-guided heart-screening plan helps childhood cancer survivors stick with important heart tests.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11400309

• Activating Pantothenate Kinase to Boost CoA for PKAN in Children

  A patient-facing program aims to raise CoA levels in the brains of children with PKAN by using a new activator of pantothenate kinase, potentially improving movement and brain health.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11398174

• Understanding how blood stem cells decide to grow or become mature cells

  Scientists are studying human blood stem cells to learn how they decide to keep renewing themselves or to turn into mature blood cells for transplant patients.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11398070

Quick answers

How many clinical trials run by St. Jude Children's Research Hospital are recruiting right now?

95, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (94 trials), Canada (2 trials), Brazil (1 trial), Jordan (1 trial), Peru (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 15, Phase 2: 15, Phase 1/2: 5, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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